{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:44:40Z","timestamp":1791139480718,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,21]],"date-time":"2002-01-21T00:00:00Z","timestamp":1011571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Research"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>Vitiligo susceptibility is a complex genetic trait that may involve genes important for melanin biosynthesis, response to oxidative stress, and\/or regulation of autoimmunity, as well as environmental factors. We report here case\u2013control and family\u2010based association studies for the <jats:italic>catalase<\/jats:italic> gene (<jats:italic>CAT<\/jats:italic>) in vitiligo patients. The <jats:italic>CAT<\/jats:italic> gene was selected as a candidate gene because of the reduction of catalase enzyme activity (EC 1.11.1.6) and concomitant accumulation of excess hydrogen peroxide observed in the entire epidermis of vitiligo patients. One of three <jats:italic>CAT<\/jats:italic> genetic markers studied was found to be informative for genotypic analysis of Caucasian vitiligo patients and control subjects. Both case\/control and family\u2010based genetic association studies of the T\/C single nucleotide polymorphism (SNP) in exon 9 of the <jats:italic>CAT<\/jats:italic> gene, which is detectable with the restriction endonuclease <jats:italic>Bst<\/jats:italic>X I, suggest possible association between the <jats:italic>CAT<\/jats:italic> gene and vitiligo susceptibility. The observations that T\/C heterozygotes are more frequent among vitiligo patients than controls and that the C allele is transmitted more frequently to patients than controls suggest that linked mutations in or near the <jats:italic>CAT<\/jats:italic> gene might contribute to a quantitative deficiency of catalase activity in the epidermis and the accumulation of excess hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>). The <jats:italic>CAT<\/jats:italic> gene may, therefore, be a susceptibility gene in some vitiligo patients, further supporting the epidermal oxidative stress model for vitiligo pathogenesis.<\/jats:p>","DOI":"10.1034\/j.1600-0749.2002.00057.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T16:36:09Z","timestamp":1047486969000},"page":"62-66","source":"Crossref","is-referenced-by-count":144,"title":["Genetic Association of the <i>Catalase<\/i> Gene (<i>CAT<\/i>) with Vitiligo Susceptibility"],"prefix":"10.1111","volume":"15","author":[{"given":"Courtney B.","family":"Casp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Xiong","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne T.","family":"Mccormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,21]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"NordlundJJ&OrtonneJP.Vitiligo vulgaris. 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