{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:11:17Z","timestamp":1792653077876,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,3,25]],"date-time":"2002-03-25T00:00:00Z","timestamp":1017014400000},"content-version":"vor","delay-in-days":417,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>Different types of periodontopathic bacterial lipopolysaccharide (LPS) exert various biological activities <jats:italic>in vitro<\/jats:italic>. However, whether or not these activities also occur <jats:italic>in vivo<\/jats:italic> remains unclear. Thus the present study investigates bone resorption, as well as local IL\u20101\u03b1 and IL\u20101\u03b2 synthesis induced by <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> LPS in the periodontal tissue of mice. Both types of LPS were injected into mouse gingiva every 48\u2003h and the animals were sacrificed 6\u2003h after the 1st, 4th, 7th, 10th, 13th, 16th, 20th, or 24th injection. Bone resorption in the injected gingiva was histopathologically and histomorphometrically investigated and local concentrations of IL\u20101<jats:italic>\u03b1<\/jats:italic> and IL\u20101<jats:italic>\u03b2<\/jats:italic> were detected using an enzyme\u2010linked immunosorbent assay. The active resorption ratio was significantly higher in the group given the 10th injection of LPS from <jats:italic>A. actinomycetemcomitans<\/jats:italic> than in the group given <jats:italic>P. gingivalis<\/jats:italic> LPS. Furthermore, <jats:italic>A. actinomycetemcomitans<\/jats:italic> LPS stimulated significantly more synthesis of IL\u20101<jats:italic>\u03b1<\/jats:italic> than <jats:italic>P. gingivalis<\/jats:italic> LPS after the 4th and 10th injections, and of IL\u20101<jats:italic>\u03b2<\/jats:italic> after the 4th, 7th, 10th, 13th, 16th and 20th injections. These results suggest that <jats:italic>A. actinomycetemcomitans<\/jats:italic> LPS is a more potent inducer of bone resorption and synthesis of IL\u20101<jats:italic>\u03b1<\/jats:italic> and IL\u20101<jats:italic>\u03b2<\/jats:italic> in the short term than <jats:italic>P. gingivalis<\/jats:italic> LPS.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2001.00637.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:54:56Z","timestamp":1047459296000},"page":"1-8","source":"Crossref","is-referenced-by-count":74,"title":["Bone resorption and local interleukin\u20101<i>\u03b1<\/i> and interleukin\u20101<i>\u03b2<\/i> synthesis induced by <i>Actinobacillus actinomycetemcomitans<\/i> and <i>Porphyromonas gingivalis<\/i> lipopolysaccharide"],"prefix":"10.1111","volume":"36","author":[{"given":"Eiji","family":"Nishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihachi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,3,25]]},"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0765.2001.00637.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0765.2001.00637.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0765.2001.00637.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T18:49:08Z","timestamp":1700419748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0765.2001.00637.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1034\/j.1600-0765.2001.00637.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0765.2001.00637.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}