{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:39:05Z","timestamp":1761057545767},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T00:00:00Z","timestamp":1031875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>The local salivary immunoglobulin A (IgA) response in patients with aggressive periodontitis to oral microorganisms and its role for the pathogenesis has not been determined. This study investigated the hypothesis that aggressive periodontitis patients have impaired oral secretory immunity. Our test group was made\u2010up of 19 aggressive periodontitis patients and 19 age\u2010 and gender\u2010matched periodontally healthy controls. Total IgA, IgA subclass 1, IgA subclass 2 and IgA reactive to <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> Y4, <jats:italic>Treponema denticola<\/jats:italic> ATCC 35404 and <jats:italic>Candida albicans<\/jats:italic> DSM 3454 were determined by enzyme\u2010linked immunosorbent assay in whole unstimulated and stimulated saliva. A statistically significantly lower concentration and secretion rate of total salivary IgA (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) and IgA1 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) was found in the aggressive periodontitis group in resting and stimulated saliva. A decrease of IgA2 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) was seen in resting saliva. Although only minor differences were detected in the concentration and secretion of bacteria\u2010reactive IgA in both groups, the proportion of bacteria\u2010reactive IgA from the total IgA was significantly higher (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) in the aggressive periodontitis group in all three microorganisms tested. Our results indicate an inhibition of total secretory IgA. In particular an IgA subclass 1\u2010specific decrease in aggressive periodontitis was noted, while the bacteria\u2010reactive humoral immune system in saliva was activated. The role of the decrease of IgA1 immunoglobulins in aggressive periodontitis with respect to susceptibility for periodontal diseases has to be elucidated.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2002.00337.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:55:51Z","timestamp":1047459351000},"page":"333-339","source":"Crossref","is-referenced-by-count":35,"title":["Salivary IgA subclasses and bacteria\u2010reactive IgA in patients with aggressive 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