{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:41:01Z","timestamp":1697506861316},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,13]],"date-time":"2002-09-13T00:00:00Z","timestamp":1031875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>We investigated the variable V\u03b1 and V\u03b2 gene usage of <jats:italic>Actinobacillus\u2003actinomycetemcomitans<\/jats:italic>\u2010reactive periodontal CD4<jats:sup>+<\/jats:sup> T cell receptors (TCR) from: (i) four <jats:italic>A.\u2003actinomycetemcomitan<\/jats:italic>s\u2010infected localized juvenile periodontitis (LJP) patients, (ii) four groups of <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\u2010inoculated NOD\/SCID mice engrafted with individual LJP\u2010derived HuPBL and (iii) HuPBL samples of four LJP patients and two healthy control subjects, by quantitative PCR analyses. The results show that: (i) the majority of the TCR genes (82.5% of V\u03b1 and 91.1% of V\u03b2) used by periodontal CD4<jats:sup>+<\/jats:sup> T cells in <jats:italic>A. actinomycetemcomitans<\/jats:italic>\u2010inoculated HuPBL\u2010engrafted NOD\/SCID mice overlap with those used by local periodontal T cells in LJP patients, (ii) although <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\u2010reactive periodontal CD4<jats:sup>+<\/jats:sup> TCR repertoire is relatively widespread, there are a few dominant genes shared by the LJP patients, suggesting a limited number of antigens or epitopes commonly recognized and (iii) <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic> likely lacks superantigenic characteristics. These results suggest <jats:italic>A.\u2003actinomycetemcomitans<\/jats:italic>\u2010associated human CD4<jats:sup>+<\/jats:sup> T cell repertoire established in HuPBL\u2010NOD\/SCID mice provides a useful approach to study specific aspects of immune\u2013parasite interactions in the periodontium.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2002.01006.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:55:51Z","timestamp":1047459351000},"page":"399-404","source":"Crossref","is-referenced-by-count":12,"title":["T\u2010cell\u2010receptor gene usage of <i>Actinobacillus actinomycetemcomitans\u2010<\/i>reactive periodontal CD4<sup>+<\/sup> T cells from localized juvenile periodontitis patients and human peripheral blood leukocyte\u2010reconstituted NOD\/SCID mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Xuijuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Tung 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