{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:35:47Z","timestamp":1773236147710,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T00:00:00Z","timestamp":1061942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Races and Gm(23) allotypes can modify the serum levels of IgG subclasses. The average serum levels of IgG subclasses of African\u2010Americans have been reported to be higher than those of Caucasians in both healthy young adults and patients with aggressive periodontitis; Gm(23)\u2010positive subjects generally had higher IgG2 levels than Gm(23)\u2010negative subjects.<\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> We examined serum immunoglobulin G (IgG) concentrations in Taiwanese patients with different forms of periodontitis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The serum levels of four IgG subclasses were determined by enzyme\u2010linked immunosorbent assay and Gm(23) allotypes were verified by radial immunodiffusion tests in 50 patients with chronic periodontitis, 30 patients with aggressive periodontitis, and 74 healthy controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were no differences in the concentrations of four IgG subclasses in patients with chronic periodontitis compared with age\u2010matched controls. However, in subjects younger than 35\u2003years, levels of IgG2 were significantly elevated in patients with aggressive periodontitis compared with controls. We also found significant differences in IgG2 levels within the control group when stratified by age (\u2264\u200335\u2003years and &gt;\u200a35\u2003years). Gm(23) allotypes were not correlated with the serum levels of IgG2 in either patient group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Microbial challenge might not provoke significant changes in systemic IgG response in patients with chronic periodontitis. However, in patients with aggressive periodontitis, IgG2 levels were increased when compared with age\u2010matched controls. Gm(23) allotypes had no influence on IgG2 levels in well\u2010established generalized chronic periodontitis or aggressive periodontitis.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2003.00675.x","type":"journal-article","created":{"date-parts":[[2003,8,27]],"date-time":"2003-08-27T08:43:31Z","timestamp":1061973811000},"page":"471-476","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin G profiles in different forms of periodontitis"],"prefix":"10.1111","volume":"38","author":[{"given":"Hsien\u2010Yang","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsi\u2010Chi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woan\u2010Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Tai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Cheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,8,27]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.781"},{"key":"e_1_2_11_3_2","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1128\/iai.64.7.2500-2505.1996","article-title":"Influence of smoking and race on immunoglobulin G subclass concentration in early onset periodontitis patients","volume":"64","author":"Quinn SM","year":"1996","journal-title":"Infect Immun"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb02340.x"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.1.1"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.5.314"},{"key":"e_1_2_11_7_2","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1128\/iai.60.6.2194-2200.1992","article-title":"Serum immunoglobulin G antibody to Porphyromonas gingivalis in rapidly progressive periodontitis; titer, avidity and subclass distribution","volume":"60","author":"Whitney C","year":"1992","journal-title":"Infect Immun"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00652.x"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1463"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02108.x"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02480.x"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/iai.62.10.4356-4361.1994","article-title":"Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamster","volume":"62","author":"Collins JG","year":"1994","journal-title":"Infect Immun"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(89)90174-6"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01561.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.31.1.182-192.1981"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb02032.x"},{"key":"e_1_2_11_17_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1128\/jb.163.2.730-734.1985","article-title":"Fimbriae from the oral anaerobe Bacteroides gingivalis. 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