{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:20Z","timestamp":1772253200608,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T00:00:00Z","timestamp":1043712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>The aim of this controlled retrospective study was to evaluate the influence of an <jats:italic>IL\u20101<\/jats:italic> gene polymorphism on the clinical and radiographic healing outcomes of GTR therapy. The study included 47 adult periodontitis patients with 94 deep intrabony defects treated by GTR using different membrane materials. The following clinical parameters were recorded at baseline and 12\u2003months after surgery: papillary bleeding index (PBI), gingival recession (REC), probing pocket depth (PPD), clinical attachment level (CAL), and the vertical <jats:italic>relative<\/jats:italic> attachment gain (V\u2010rAG). Bone changes in the defect regions due to GTR therapy were quantitatively evaluated using digital subtraction radiography (DSR). Polymorphisms of the IL\u20101A gene at position \u2212\u200a889 and of the IL\u20101B gene at position +\u200a3953 were analyzed by PCR. Statistical analysis was performed using the Mann\u2013Whitney\u2010U and the Wilcoxon\u2010Signed\u2010Rank tests (\u03b1\u2003=\u20030.05). The study comprised 19 IL\u20101 genotype positive (<jats:italic>IL\u20101\u2003+<\/jats:italic>) patients and 28 IL\u20101 genotype negative (<jats:italic>IL\u20101\u2003\u2013<\/jats:italic>) patients. Twelve months after GTR therapy, both patient groups revealed statistically significant PPD reductions and CAL gain [median (25\/75% percentiles)]: \u0394PPD [<jats:italic>IL\u20101\u2003+<\/jats:italic>\u2003: 4.0 (2.5\/5.0) mm; <jats:italic>IL\u20101\u2010<\/jats:italic>: 3.8 (3.0\/4.9) mm], \u0394CAL [<jats:italic>IL\u20101\u2003+<\/jats:italic>\u2003: 3.5 (3.0\/4.8) mm; <jats:italic>IL\u20101\u2003\u2013<\/jats:italic>: 3.0 (1, 2\/4, 5) mm]. V\u2010rAG amounted to 60.0 (47.7\/78.6)% in <jats:italic>IL\u20101\u2003+<\/jats:italic> patients and 53.1 (43.4\/81.9)% in <jats:italic>IL\u20101\u2003\u2013<\/jats:italic> patients. Both patient groups showed significant bone density gain in 40% (<jats:italic>IL\u20101\u2003+<\/jats:italic>) and 43.6% (<jats:italic>IL\u20101 \u2013<\/jats:italic>) of the initial defect area due to GTR. Neither the clinical nor the radiographic healing parameters revealed any statistically significant differences in the GTR healing outcome between <jats:italic>IL\u20101\u2003+ and IL\u20101\u2003\u2013<\/jats:italic> patients. In conclusion, these 12\u2010month findings indicate that the <jats:italic>IL\u20101<\/jats:italic> gene polymorphism has no influence on the clinical and radiographic regeneration results following GTR therapy.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2003.01373.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:56:15Z","timestamp":1047459375000},"page":"20-27","source":"Crossref","is-referenced-by-count":15,"title":["Influence of interleukin\u20101 gene polymorphism on periodontal regeneration in intrabony defects"],"prefix":"10.1111","volume":"38","author":[{"given":"M.","family":"Christgau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Aslanidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Felden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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