{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:49:34Z","timestamp":1763704174876},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,28]],"date-time":"2003-01-28T00:00:00Z","timestamp":1043712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>The distribution of immunocompetent cells in the dentogingival junction of rat molars during root formation was investigated by immunocytochemistry using antibodies to class II major histocompatibility complex (MHC) molecules (OX6\u2010antibody) and monocyte\/macrophage lineage cells (ED1\u2010antibody) as well as by histochemical reaction for periodic acid\u2013Schiff (PAS). Two portions (the junctional epithelium in the mesial gingiva of the first molar, and the interdental gingiva between the first and second molars) were selected for observations. At the eruption stage of the first molar (16\u201318\u2003days after birth), OX6\u2010positive cells, dendritic or oval in shape, were abundantly distributed in the connective tissue between the oral epithelium and tooth germ. Positive cells with slender cell processes were also found beneath the ameloblast layer. At the commencement stage of the first molar occlusion (24\u201328\u2003days after birth), numerous OX6\u2010positive cells displaying a dendritic fashion existed preferentially in the mesial gingiva, but were fewer in the interdental gingiva. In contrast, the interdental gingiva showed a denser distribution of ED1\u2010positive cells and PAS\u2010reactive polymorphonuclear leukocytes (PMLs) than the mesial gingiva. At the completion stage of root formation (100\u2013120\u2003days after birth), the OX6\u2010immunopositive cells invaded the deeper position of the mesial gingiva with the downgrowth of the epithelium; they had a considerably higher cell density compared with those in the interdental gingiva where PAS\u2010reactive PMLs persisted. These findings indicated that the immunocompetent cells showed a region\u2010specific distribution and cell density by their roles in immune response.<\/jats:p>","DOI":"10.1034\/j.1600-0765.2003.01622.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:56:15Z","timestamp":1047459375000},"page":"10-19","source":"Crossref","is-referenced-by-count":4,"title":["Different distribution of immunocompetent cells in the dentogingival junction during root formation in rat molars"],"prefix":"10.1111","volume":"38","author":[{"given":"Hiroshi","family":"Tamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniko","family":"Nakakura\u2010Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyasu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,28]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"233","volume-title":"Handbook of microscopic anatomy V\/5: the periodontium.","author":"Schreoder HE","year":"1986"},{"key":"e_1_2_9_3_2","first-page":"253","volume-title":"Oral histology. 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