{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:59:32Z","timestamp":1773395972136,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,10,23]],"date-time":"2002-10-23T00:00:00Z","timestamp":1035331200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology &amp; Toxicology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p><jats:bold>Abstract:<\/jats:bold> Pien Tze Huang, a traditional Chinese medicine, has been extensively used as a therapeutic drug in the treatment of liver diseases. In this study, we have examined its ability to protect the liver from carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced damage in the mouse. Histological observations revealed that CCl<jats:sub>4<\/jats:sub> treatment induced extensive degenerative changes in the hepatocytes surrounding the central veins of the liver. However, these changes were much reduced by more than 28% in mice fed with 0.5 mg of Pien Tze Huang\/g body weight\/dose (3 doses over 36 hr) prior to CCl<jats:sub>4<\/jats:sub> treatment. The effects of Pien Tze Huang were then further investigated in a hepatoma cell line. Flow analysis showed that it had no significant effects on cell proliferation. When the ability of Pien Tze Huang to influence various response elements of important signal transduction pathways was examined in the hepatoma cell line, it was found that Pien Tze Huang stimulated an increase in the response of AP1, CRE and NF\u03baB responsive elements. The transcriptional factors of these responsive elements are known to play important roles in regulating cell death and survival. We thus postulate that the ability of Pien Tze Huang to protect the liver from damage is attained through its ability to modulate the activity of these important signal transduction pathways.<\/jats:p>","DOI":"10.1034\/j.1600-0773.2002.910406.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:55:49Z","timestamp":1047495349000},"page":"185-192","source":"Crossref","is-referenced-by-count":25,"title":["Pien Tze Huang Protects the Liver against Carbon Tetrachloride\u2010Induced Damage"],"prefix":"10.1111","volume":"91","author":[{"given":"Kenneth K. H.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Hang","family":"Kwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foo\u2010tim","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Yew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wood Yee","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,10,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"129","article-title":"The role of Jun, Fos and the AP\u20101 complex in cell\u2010proliferation and transformation","volume":"1072","author":"Angel P.","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(98)01251-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500050401"},{"key":"e_1_2_6_5_1","volume-title":"The assays of the active ingredients of some common traditional Chinese medicines (in Chinese)","author":"Chen F.K.","year":"1997"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X00000222"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01719-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116332"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.2100770.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/365179a0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046895"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0249"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8569"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X00000210"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X00000428"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/328175a0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X97000093"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1999.5784"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.270.42.24995","article-title":"Activation of transcriptional factor NF\u2010\u03baB is suppressed by curcumin (diferulolylmethane)","volume":"270","author":"Singh S.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.4.8647340"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117730"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(00)80035-5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X00000209"},{"key":"e_1_2_6_24_1","volume-title":"The encyclopaedia of Chinese medicines (in Chinese)","author":"Zhang G. J.","year":"1995"}],"container-title":["Pharmacology &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0773.2002.910406.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0773.2002.910406.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0773.2002.910406.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:22:40Z","timestamp":1697545360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0773.2002.910406.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1034\/j.1600-0773.2002.910406.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0773.2002.910406.x","archive":["Portico"],"relation":{},"ISSN":["0901-9928"],"issn-type":[{"value":"0901-9928","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}