{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:53:11Z","timestamp":1773384791010,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p><jats:bold>Background\/Purpose:<\/jats:bold> Free oxygen radicals are involved in inflammatory skin reactions induced by ultraviolet B\u00a0(UVB). In this study, the effect of a herbal antioxidant <jats:italic>Ginkgo biloba<\/jats:italic> extract (EGb 761) was investigated in UVB irradiated mice skin.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study was carried out on four groups of mice (<jats:italic>n<\/jats:italic>\u2003=\u20036 in each group). The first group was a control group (G1). The second group (G2) was only exposed to acute UVB irradiation. The third group (G3) received 100\u2003mg\/kg\/day of EGb 761 orally for 5\u2003days before UVB irradiation and the fourth group (G4) was given only a single dose of EGb 761 immediately after UVB irradiation. Eighteen hours after exposing to UVB, lipid peroxide levels, and superoxide dismutase (SOD) activities were studied and UVB damage was evaluated histopathologically according to \u2018sun\u2010burn cell count\u2019.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The SOD activities and Malondialdehyde (MDA) levels in G2, G3 and G4 were found to be decreased significantly when compared with G1 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The SOD activities of G3 and G4 were higher when compared with G2 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The number of sunburn cells (SBCs) was the highest in G2.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our results suggest that EGb 761 may have an important effect, both as a protective and therapeutic agent, in sunburn after UVB irradiation.<\/jats:p>","DOI":"10.1034\/j.1600-0781.2002.00727.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T18:35:23Z","timestamp":1047494123000},"page":"117-120","source":"Crossref","is-referenced-by-count":27,"title":["The effects of EGb 761 on lipid peroxide levels and superoxide dismutase activity in sunburn"],"prefix":"10.1034","volume":"18","author":[{"given":"Mehtap Kilinc","family":"Ozkur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meral Sasoglu","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbaros","family":"Balabanli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Aricioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilsel","family":"Ilter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"G\u00fcrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Serhat","family":"Inal\u00f6z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1365-313X.1992.t01-33-00999.x","article-title":"Differential response of maize catalases and superoxide dismutases to the photoactivated fungal toxin cercosporin","volume":"2","author":"Williamson JD","year":"1992","journal-title":"Plant J"},{"key":"e_1_2_5_3_2","first-page":"609","article-title":"Hypersensitivity of human lymphocytes to UV\u2010B and solar irradiation","volume":"53","author":"Arlett CF","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1139\/o90-146"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90059-Z"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6857269"},{"key":"e_1_2_5_7_2","first-page":"247","article-title":"Auto\u2010oxidative damage in Behcet's Disease endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils","volume":"49","author":"Niwa Y","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000213257"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90310-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(80)90010-1"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(68)90168-9"},{"key":"e_1_2_5_12_2","first-page":"293","article-title":"Lipid peroxide levels and superoxide dismutase activity in UVB\u2010irradiated mouse skin","volume":"100","author":"Nishi T","year":"1990","journal-title":"Jpn J\u00a0Dermatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12284412"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1995.tb00157.x"},{"key":"e_1_2_5_15_2","first-page":"70","article-title":"Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications","volume":"7","author":"McKenna DJ","year":"2001","journal-title":"Altern Ther Health Med"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01974564"},{"key":"e_1_2_5_17_2","first-page":"386","article-title":"Histopathological assessment of the prophylactic effect of Ginkgo biloba extract on intestinal ischemia\u2010reperfusion injury","volume":"62","author":"Onen A","year":"1999","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(00)90052-2"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.102.907"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb04759.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1984.tb03914.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42815-9"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_5_24_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A\u00a0simple method for clinical assay of superoxide dismutase","volume":"34","author":"Su Y","year":"1988","journal-title":"Clin Chem"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(90)90085-2"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000248458"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90550-9"},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2340\/0001555571239242","article-title":"UVB irradiation induces lipid peroxidation and reduces antioxidant enzyme activities in human keratinocytes in vitro","volume":"71","author":"Punnonen K","year":"1991","journal-title":"Acta Derm Venerol"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00695a010"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83842-5"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(77)80151-4"},{"key":"e_1_2_5_33_2","first-page":"37","volume-title":"Recent Results in Pharmacology and Clinic","author":"Moreau JP","year":"1988"}],"container-title":["Photodermatology, Photoimmunology &amp; 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