{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:15:25Z","timestamp":1771229725322,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,4,30]],"date-time":"2002-04-30T00:00:00Z","timestamp":1020124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>The duck pineal gland rhythmically produces two 5\u2010methoxyindole compounds, i.e. 5\u2010methoxytryptophol and melatonin. 5\u2010Methoxytryptophol levels are low at night and high during the day, while melatonin concentrations are high at night and low during the day. The melatonin rhythm reflects oscillations in the activity of serotonin <jats:italic>N<\/jats:italic>\u2010acetyltransferase (AA\u2010NAT; a penultimate and key regulatory enzyme in the melatonin biosynthetic pathway). The activity of hydroxyindole\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (HIOMT; an enzyme involved in the synthesis of both 5\u2010methoxytryptophol and melatonin) does not exhibit any significant rhythmic changes throughout the 24\u2010hr period. Plasma levels of melatonin exhibited daily changes that were parallel to fluctuations in pineal melatonin content. Although plasma concentrations of 5\u2010methoxytryptophol were low in ducks, they showed daily variations. The mean 5\u2010methoxytryptophol concentration between zeitgeber time 9 (ZT9) and ZT15 was 2.4\u2010times higher than the mean value for samples collected between ZT18 and ZT3. These findings indicate that in the duck the pineal production of 5\u2010methoxytryptophol and melatonin may be inversely correlated.<\/jats:p>","DOI":"10.1034\/j.1600-079x.2002.01835.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T08:32:33Z","timestamp":1047457953000},"page":"214-218","source":"Crossref","is-referenced-by-count":15,"title":["Daily variation in the concentration of 5\u2010methoxytryptophol and melatonin in the duck pineal gland and plasma"],"prefix":"10.1111","volume":"32","author":[{"given":"Jolanta B.","family":"Zawilska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Rosiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthe","family":"Vivien\u2010Roels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra J.","family":"Skene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"P\u00e9vet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy Z.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,4,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-4644(20000315)76:4<651::aid-jcb13>3.0.co;2-h"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01339-J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1991.tb00012.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1992.tb00051.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1139\/o00-018"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1996.tb00273.x"},{"key":"e_1_2_6_8_2","first-page":"87","article-title":"Action of pineal indoles on the reproductive system of the male C57 mouse and golden hamster","volume":"93","author":"NG T.B.","year":"1993","journal-title":"J. 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