{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:40:24Z","timestamp":1700412024601},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,1,13]],"date-time":"2002-01-13T00:00:00Z","timestamp":1010880000000},"content-version":"vor","delay-in-days":257,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p><jats:bold>Background\/aims: <\/jats:bold> Fluorescein dermofluorometry can be used to relate the uptake of fluorescein in the skin to blood flow. We have characterized the uptake of the dye by a wash\u2010in time constant that is inversely proportional to the local blood flow. The purpose of this study was to explore the use of dermofluorometry in the assessment of patients with diabetic microvascular disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fluorescein dermofluorometry was performed in four groups of patients: non\u2010diabetic control patients, diabetic control patients, diabetic patients with chronic foot ulcers, and diabetic patients with acute foot ulcers. The outcomes of the patients with foot ulcers were documented 4\u201314 months after participation. Following an intravenous injection of sodium fluorescein, the change in the fluorescein signal with time was continuously measured at the plantar surface of the foot. Both the initial slope of the signal and the wash\u2010in time constant were calculated in each subject.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant differences in the wash\u2010in time constant were found between diabetic and non\u2010diabetic subjects and between diabetic subjects with and without foot ulcers. Of the eight patients with foot ulcers, two of them did not display an early wash\u2010out in the dermofluorometer signal and later both required amputations.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The fluorescein wash\u2010in time constant demonstrated better correlation with the presence of diabetic microvascular disease than did the initial slope of the signal. Differences in the wash\u2010in time constants of non\u2010diabetic and diabetic subjects support the hemodynamic hypothesis for the development of microvascular disease. The indication of early wash\u2010out of the fluorescein signal may also be useful in the prediction of ulcer healing.<\/jats:p>","DOI":"10.1034\/j.1600-0846.2001.70209.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:43:59Z","timestamp":1047501839000},"page":"105-111","source":"Crossref","is-referenced-by-count":3,"title":["Fluorescein dermofluorometry for the assessment of diabetic microvascular disease"],"prefix":"10.1111","volume":"7","author":[{"given":"Deborah K.","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard N.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Magin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,13]]},"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0846.2001.70209.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0846.2001.70209.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0846.2001.70209.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:15:03Z","timestamp":1700410503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0846.2001.70209.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1034\/j.1600-0846.2001.70209.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0846.2001.70209.x","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}