{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T10:31:01Z","timestamp":1768300261306,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T00:00:00Z","timestamp":1042588800000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Jablonowska B, Palfi M, Matthiesen L, Selbing A, Kjellberg S, Ernerudh J. T and B Lymphocyte subsets in patients with unexplained recurrent spontaneous abortion: IVIG versus placebo treatment. AJRI 2002; 48:312\u2013318 \u00a9 Blackwell Munksgaard, 2002<\/jats:p><jats:p>PROBLEM:\u2002To investigate circulating lymphocyte subsets in women with recurrent spontaneous abortion (RSA) in relation to pregnancy outcome and to treatment with intravenous immunoglobulin (IVIG).<\/jats:p><jats:p>METHOD OF STUDY:\u2002Forty\u2010one women with a history of unexplained RSA were examined during first trimester of pregnancy before IVIG or placebo treatment and after pregnancy. The results were compared with five healthy, non\u2010pregnant women and five women in the first trimester of normal pregnancy. Circulating lymphocyte subsets with focus on T\u2010cell subpopulations were determined by flow cytometry.<\/jats:p><jats:p>RESULTS:\u2002The proportions of human leukocyte antigen (HLA)\u2010DR positive T cells (CD3+ HLA\u2010DR+), T\u2010killer\/effector cells (CD8+\u2003S6F1+) and B cells (CD19+) were increased, whereas the proportion of T\u2010suppressor\/inducer cells (CD4+\u2003CD45RA+) was decreased during first trimester pregnancy of RSA women compared with pregnant normal controls. T and B lymphocyte subsets did not correlate with pregnancy outcome on either IVIG or placebo group.<\/jats:p><jats:p>CONCLUSIONS:\u2002In RSA patients, the immune system seems to be activated in contrast to the suppression noted in normal pregnancy.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01010.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:27:15Z","timestamp":1047346035000},"page":"312-318","source":"Crossref","is-referenced-by-count":15,"title":["T and B Lymphocyte Subsets in Patients with Unexplained Recurrent Spontaneous Abortion: IVIG versus Placebo 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