{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:59:08Z","timestamp":1757311148629},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2230,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>PROBLEM:\u2002Female mice that are injected with estradiol\u201017\u03b2 (E<jats:sub>2<\/jats:sub>) and testosterone during the 7\u2010day immune adaptive period are infertile at adulthood. To determine whether the resultant infertility can be caused by steroids other than estrogens\/androgens, this study examined the effect of injecting cortisone, alone, and in combination with E<jats:sub>2<\/jats:sub> and testosterone, on reproductive function.<\/jats:p><jats:p>METHOD OF STUDY:\u2002Neonatal (C57BL\/6J\u2003\u00d7\u2003A\/J)<jats:italic>F<\/jats:italic><jats:sub>1<\/jats:sub> B6A female mice were injected from 3 to 6\u2003days of age with sesame oil:ethanol (9:1; v:v), alone, or containing 20\u2003\u03bcg cortisone acetate, 20\u2003\u03bcg E<jats:sub>2<\/jats:sub>, or 20\u2003\u03bcg testosterone. Two additional groups were given 20\u2003\u03bcg cortisone acetate in combination with 20\u2003\u03bcg E<jats:sub>2<\/jats:sub> or 20\u2003\u03bcg testosterone. At adulthood the animals were killed, the stage of vaginal estrus determined, the ovaries examined for the presence of corpora lutea and follicular cysts, and circulating levels of progesterone, E<jats:sub>2<\/jats:sub>, and testosterone were measured by radioimmunoassay (RIA).<\/jats:p><jats:p>RESULTS:\u2002It was found that injections of cortisone seriously compromise reproductive development. For example, 11% of cortisone\u2010injected animals had ovaries that lacked corpora lutea. In addition, 39% of cortisone\u2010injected females had ovaries with follicular cysts. Cortisone\u2010injected females also had low levels of circulating progesterone (18\u2003ng\/mL versus 30\u2003ng\/mL for the sesame oil\u2010injected females).<\/jats:p><jats:p>CONCLUSION:\u2002It is concluded that the deleterious effect of steroids on reproductive function, when administered during the immune adaptive period, is not restricted to estrogens and androgens. It is proposed that injections of cortisone alter T\u2010lymphocyte subsets, which contributes to anovulation and the production of follicular cysts.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01081.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:27:03Z","timestamp":1047346023000},"page":"184-189","source":"Crossref","is-referenced-by-count":6,"title":["The Administration of Cortisone to Female B6A Mice During their Immune Adaptive Period Causes Anovulation and the Formation of Ovarian Cysts"],"prefix":"10.1111","volume":"48","author":[{"given":"John C.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soohong","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saichol","family":"Kunaporn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saureen","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra D.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-85-20989"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-68-1-68"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-68-1-62"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1963.205.5.842"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-73-2-210"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod42.1.21"},{"key":"e_1_2_5_8_2","unstructured":"GorskiRA:Steroid\u2010induced sexual characteristics in the brain.InNeuroendocrine Function EE Muller RM MacLeod (eds). 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