{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:59:04Z","timestamp":1771102744203,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,6,19]],"date-time":"2002-06-19T00:00:00Z","timestamp":1024444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>PROBLEM:\u2002At least two dendritic cell\u2010associated molecules have been shown to contribute to the successful outcome of organ and tissue allografts in mice, namely CD200 and MD\u20101. CD200 is up\u2010regulated in rodent transplantation models where successful inhibition of rejection is accomplished, and is believed to signal immunosuppression following engagement of a receptor, CD200R, on macrophages and\/or \u03b3\u03b4 T\u2010cell receptor (\u03b3\u03b4 TCR<jats:sup>+<\/jats:sup>cells MD\u20101 is implicated in controlling expression of costimulatory molecules including CD80\/CD86 which induce an immunorejection response, and thus inhibition of MD\u20101 expression also facilitates increased graft survival MD\u20101 also stabilizes expression of CD14, part of the receptor complex for LPS. As well as the inhibition of rejection which follows blockade of MD\u20101 expression and\/or augmentation of CD200 expression, an altered polarization in cytokine production is seen, with increased expression of interleukin\u20104 (IL\u20104), IL\u201010 and transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2), and decreased IL\u20102, interferon\u2010\u03b3 (IFN\u2010\u03b3) and tumor nerosis factor\u2010\u03b1 (TNF\u2010\u03b1). Successful pregnancy in allopregnant mice also depends upon control of graft rejection mechanisms. Proinflammatory T\u2010helper 1 (Th1) cytokines (TNF\u2010\u03b1\u2003+\u2003IFN\u2010\u03b3\u2003+\u2003IL\u20101) have been shown to cause spontaneous abortion in mice by activating a novel prothrombinase, fibrinogen\u2010like peptide (fibroleukin) fgl2, which may promote fibrin deposition in the graft rejection process; expression of IL\u201010, TGF\u2010\u03b2, and progesterone\u2010induced blocking factor (PIBF) in contrast leads to lowering of abortion rates. Interestingly, the spontaneous abortion rates in abortion\u2010prone CBA\u2003\u00d7\u2003DBA\/2 matings and in the low abortion rate CBA\u2003\u00d7\u2003BALB\/c matings were lower than the frequency of implantation sites showing fibrin<jats:sup>hi<\/jats:sup>+ fgl2 (mRNA)<jats:sup>hi<\/jats:sup>, implying regulation of the pro\u2010abortion consequences of fgl2 expression.<\/jats:p><jats:p>METHODS:\u2002We have investigated, by<jats:italic>in situ<\/jats:italic>hybridization, CD200, MD\u20101\u2003and fgl2 expression in implantation sites in different strains of mice, and studied the effects of anti\u2010MD\u20101, anti\u2010CD200 and CD200Fc immunoadhesin on fetal and allograft survival. The role of indoleamine dioxygenase (IDO) was evaluated.<\/jats:p><jats:p>RESULTS:\u2002CD200 mRNA expression occurred in the same sites as fgl2 mRNA. Anti\u2010CD200 antibody raised the abortion rate to predicted levels, and infusion of a CD200 immunoadhesin reduced the abortion rate, as did an anti\u2010MD\u20101 antibody. The latter also improved organ and tissue graft survival. Suppression by antigen\u2010presenting macrophages triggered by CD200 is dependent upon intact IDO activity.<\/jats:p><jats:p>CONCLUSION:\u2002Regulation of CD200 and MD\u20101 expression may control both pregnancy and allograft survival.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01094.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:26:43Z","timestamp":1047346003000},"page":"18-26","source":"Crossref","is-referenced-by-count":76,"title":["The Same Immunoregulatory Molecules Contribute to Successful Pregnancy and Transplantation"],"prefix":"10.1111","volume":"48","author":[{"given":"REGINALD 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