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IL\u20101beta was positively correlated with leukocyte counts in the smear both in healthy and bacterial vaginosis positive women.<\/jats:p><jats:p>CONCLUSIONS:\u2002Induction of the proinflammatory cytokine IL\u20101beta may be a necessary event to elicit an innate immune response to control anaerobic genital tract infections. High levels of vaginal IL\u20101beta are associated with mounting of an antigen\u2010specific mucosal immune response in women with bacterial vaginosis. Parallel induction of innate and adaptive immune response may be associated with protection from ascent of micro\u2010organisms to the upper genital tract, and from acquiring viral infection through the vaginal tract.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01096.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:26:47Z","timestamp":1047346007000},"page":"257-264","source":"Crossref","is-referenced-by-count":59,"title":["Correlation of Local Interleukin\u20101beta Levels with Specific IgA Response Against <i>Gardnerella vaginalis<\/i> Cytolysin in Women with Bacterial Vaginosis"],"prefix":"10.1111","volume":"47","author":[{"given":"SABINA","family":"CAUCI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SILVIA","family":"DRIUSSI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SECONDO","family":"GUASCHINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MIRIAM","family":"ISOLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FRANCO","family":"QUADRIFOGLIO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90337-I"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200005001-00001"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13625180008500398"},{"key":"e_1_2_5_5_2","first-page":"48","article-title":"Local immune response and bacterial factors in pregnant, fertile age and postmenopausal women","volume":"11","author":"Cauci S","year":"1999","journal-title":"Minerva Biotecnologica"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01063-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199813000-00019"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-0997(2000)8:3\/4<184::AID-IDOG16>3.0.CO;2-P"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-999-0048-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512283332604"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91112-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.297-301.1991"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70112-6"},{"key":"e_1_2_5_14_2","unstructured":"CauciS:Mucosal immune response and microbial factors in bacterial vaginosis.InVaginal Flora in Health and Disease. 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