{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:02:27Z","timestamp":1791018147118,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,6,19]],"date-time":"2002-06-19T00:00:00Z","timestamp":1024444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>PROBLEM:\u2002Human endometrial glands contain the highest levels of cyclooxygenase (COX), although whether it is COX\u20101 and\/or COX\u20102 has not been previously determined. Overexpression of COX\u20102 may result in the pathogenesis of endometriosis.<\/jats:p>\n                  <jats:p>METHOD OF STUDY:\u2002Tissue sections were obtained from 28 premenopausal women undergoing laparotomy or laparoscopic surgery for benign conditions. Endometrium, ectopic endometriosis tissue and peritoneum were obtained at the time of surgery. Informed consents were obtained from all the patients participating in this study. Immunohistochemistry was performed on consecutive sections of paraffin\u2010embedded tissue using anti\u2010COX\u20102 antibody. Expressions of COX\u20102 mRNA in endometrium, ectopic endometriosis tissue, and peritoneum were quanti\u2010tavely determined by competitive reverse transcription\u2013polymerase chain reaction (RT\u2013PCR).<\/jats:p>\n                  <jats:p>RESULTS:\u2002In the uterus, COX\u20102 was localized in the endometrial epithelium. Eutopic endometrial surface epithelium contains more COX\u20102 than does glandular epithelium. We observed more frequent and denser COX\u20102 staining in the ectopic endometriosis implants when compared with eutopic endometrium. Level of COX\u20102 mRNA in endometriosis was increased up to five times that of eutopic endometria.<\/jats:p>\n                  <jats:p>CONCLUSION:\u2002Hyper activation of COX\u20102 with abnormal prostaglandin generation is considered to contribute to the pathophysiology of endometriosis and disease progression.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01101.x","type":"journal-article","created":{"date-parts":[[2003,3,10]],"date-time":"2003-03-10T20:26:43Z","timestamp":1047328003000},"page":"50-56","source":"Crossref","is-referenced-by-count":118,"title":["Increased Expression of Cyclooxygenase\u20102 in Local Lesions of Endometriosis Patients"],"prefix":"10.1111","volume":"48","author":[{"given":"FUMIHISA","family":"CHISHIMA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SATOSHI","family":"HAYAKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KENJI","family":"SUGITA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORIKO","family":"KINUKAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHEIKE","family":"ALEEMUZZAMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORIMICHI","family":"NEMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TATSUO","family":"YAMAMOTO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MITSUO","family":"HONDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,6,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0015-0282(16)49814-6","article-title":"Classification of endometriotic implants by morphologic appearance and capacity to synthesize Prostaglandin F","volume":"46","author":"Vermon MN","year":"1986","journal-title":"Fertil Steril"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90033-8"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90667-X"},{"key":"e_1_2_5_5_2","first-page":"48","article-title":"Peritoneal fluid prostaglandins in various stage of the menstrual cycle: role in infertile patients with endometriosis","volume":"30","author":"Badawy SZA","year":"1985","journal-title":"Int J Fertil"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(95)00194-8"},{"key":"e_1_2_5_7_2","first-page":"4424","article-title":"Transcription of cyclooxygenase\u20102 is enhanced in transformed mammary epithelial cell","volume":"56","author":"Subbaranaiah K","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/18.4.795"},{"key":"e_1_2_5_9_2","unstructured":"RaoChV CheginiN LeiZM:Immunocytochemical localization of 5\u2010 and 12\u2010 lipoxygenases and cyclooxygenase in nonpregnant human uteri.InLeukotrienes and Prostanoids in Health and Disease. New Trends in Lipid Mediators Research. U Zor Z Naor A Danon (eds). Basel Karger 1989 pp. 283\u2013286."},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.3.561"},{"key":"e_1_2_5_11_2","first-page":"991","article-title":"Cyclooxgenase\u20102 expression is up\u2010regulated in Squamous cell carcinoma of the head and neck","volume":"59","author":"Chan G","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90333-4"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-5-1044"},{"key":"e_1_2_5_14_2","first-page":"953","article-title":"Macrophage\u2010conditioned media enhance endometrial stromal cell proliferation in vitro","volume":"164","author":"Olive DL","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57059-9"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/347669a0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(78)90176-4"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(76)90196-9"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(78)90138-7"},{"key":"e_1_2_5_20_2","first-page":"362","article-title":"Modulation of apoptosis and Bcl\u20102 expression by prostaglandin E2 in human colon cancer cells","volume":"58","author":"Sheng H","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81433-6"},{"key":"e_1_2_5_22_2","first-page":"1208","article-title":"Non\u2010small cell lung cancer cyclooxygenase\u20102\u2010dependent regulayion of cytokine balance in lymphocytes and macrophages: up\u2010regulation of interleukin 10 and down\u2010regulation of interleukin 12 production","volume":"58","author":"Huang M","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(84)90237-5"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56097-X"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-4-1000"},{"key":"e_1_2_5_26_2","first-page":"15","article-title":"The role of humoral immunity in endometriosis","volume":"159","author":"Gleicher N","year":"1994","journal-title":"Acta Obstet Gynecol Scand"},{"key":"e_1_2_5_27_2","first-page":"914","article-title":"Antiendometrial antibodies in endometriosis measured by a enzyme\u2010linked immunosorbent assay before and after treatment with danazol and nafarelin","volume":"75","author":"Kennedy SH","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2000.tb01298.x"},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1055\/s-0038-1649811","article-title":"Increased expression of inducible cyclooxygenase\u20102 in human endothelial cells by antiphospholipid antibodies","volume":"74","author":"Habib A","year":"1995","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00036.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(88)90099-8"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00592-9"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0897.2002.01101.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0897.2002.01101.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0897.2002.01101.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:06:38Z","timestamp":1697515598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0897.2002.01101.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,19]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1034\/j.1600-0897.2002.01101.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0897.2002.01101.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,19]]}}}