{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:28:56Z","timestamp":1775064536954,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T00:00:00Z","timestamp":1031184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p> <jats:italic>Makino T. Recurrent reproductive wastage and immunologic factors. AJRI 2002; 48:266\u2013268 \u00a9 Blackwell Munksgaard, 2002<\/jats:italic> <\/jats:p><jats:p>PROBLEM: The causes of recurrent reproductive wastage are varied and complex. The present study was designed to focus on the role of immunologic factors in cases where other causes were not evident.<\/jats:p><jats:p>METHOD OF STUDY: Over 20\u2003years, more than 1500 couples were evaluated in our clinic because of recurrent spontaneous abortion. Women were tested for anti\u2010phospholipid antibodies and plasma contact proteins of the intrinsic pathway of blood coagulation after endocrine, organic, infectious and genetic etiologies of miscarriages were excluded.<\/jats:p><jats:p>RESULTS: Anti\u2010phosphatidylethanolamine antibodies, anti\u2010annexin antibodies, and factor XII deficiency were more common factors in recurrent spontaneous abortion patients than were anti\u2010cardiolipin antibodies in terms of induction of recurrent pregnancy losses. Paternal leukocyte immunotherapy of patients without such abnormalities was associated with a significantly improved success rate.<\/jats:p><jats:p>CONCLUSIONS: Recurrent reproductive wastage can be minimized by individualized therapy based on comprehensive evaluation of immunologic factors, including several anti\u2010phospholipid antibodies.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2002.01114.x","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T01:26:59Z","timestamp":1047346019000},"page":"266-268","source":"Crossref","is-referenced-by-count":9,"title":["Recurrent Reproductive Wastage and Immunologic Factors"],"prefix":"10.1111","volume":"48","author":[{"given":"TSUNEHISA","family":"MAKINO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807283190401"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","unstructured":"LeaRG ClarkDA:Macrophages and other migratory cells in endometrium relevant to implantation.InBallier's Clinical Obstetrics and Gynecology M Seppala (ed.). 1991 Vol. 5 pp 231\u2013241.","DOI":"10.1016\/S0950-3552(05)80069-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90057-6"},{"key":"e_1_2_5_5_2","unstructured":"MakinoT:Current management of recurrent fetal loss.InFrontiers in Obstetrics and Gynecology Proceedings of the 53rd Annual Congress of Japan Society of Obstetrics and Gynecology 2001 pp 223\u2013226."},{"key":"e_1_2_5_6_2","first-page":"167","article-title":"Incidence of congenital uterine anomalies in repeated reproductive wastage and prognosis for pregnancy after metroplasty","volume":"37","author":"Makino T","year":"1992","journal-title":"Int J Fertil"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90794-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00119-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","unstructured":"SugiT MakinoT:Antiphospholipid antibodies and kininogens in pathological pregnancies: a review.Amer J Reprod Immunol2002.","DOI":"10.1034\/j.1600-0897.2002.01103.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2000.440506.x"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0897.2002.01114.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1600-0897.2002.01114.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1600-0897.2002.01114.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:27:48Z","timestamp":1697416068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1600-0897.2002.01114.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,5]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1034\/j.1600-0897.2002.01114.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1600-0897.2002.01114.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,5]]}}}