{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:59:39Z","timestamp":1700265579657},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T00:00:00Z","timestamp":1047859200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p><jats:bold>PROBLEM:\u2002<\/jats:bold> In T lymphocytes, nuclear factor of activated T cells (NF\u2010AT) regulates the induction of cytokine genes upon antigenic stimulation. This study was designed to analyse the relationship between NF\u2010AT and pregnancy.<\/jats:p><jats:p><jats:bold>METHOD OF STUDY:\u2002<\/jats:bold> With informed consent, peripheral blood cells (PBCs) were obtained from non\u2010pregnant (<jats:italic>n<\/jats:italic>\u2003=\u2003114), pregnant (<jats:italic>n<\/jats:italic>\u2003=\u2003604), and puerperal women (<jats:italic>n<\/jats:italic>\u2003=\u200352). The expression of NF\u2010AT2 and NF\u2010AT3 mRNAs in PBCs was measured by a quantitative reverse transcriptase\u2010polymerase chain reaction method.<\/jats:p><jats:p><jats:bold>RESULTS:\u2002<\/jats:bold> In the early pregnancy period, in successful pregnancy, both NF\u2010AT2 and NF\u2010AT3 mRNAs increased significantly, whereas in cases of spontaneous abortion they did not change significantly. After peaking, they decreased gradually and were re\u2010elevated in the ninth and tenth gestational month. In the puerperal period, NF\u2010AT3 mRNAs decreased, but NF\u2010AT2 mRNA showed a comparatively high expression level.<\/jats:p><jats:p><jats:bold>CONCLUSION:\u2002<\/jats:bold> These findings suggested that in humans NF\u2010AT signal transduction might be involved in alloantigenic recognition and tolerance and play important roles, especially in the early and late period of pregnancy.<\/jats:p>","DOI":"10.1034\/j.1600-0897.2003.01165.x","type":"journal-article","created":{"date-parts":[[2004,12,18]],"date-time":"2004-12-18T16:19:49Z","timestamp":1103386789000},"page":"139-148","source":"Crossref","is-referenced-by-count":3,"title":["Expression of Nuclear Factor of Activated T Cells mRNA in Maternal Peripheral Blood 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