{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:47:46Z","timestamp":1780440466655,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":2169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>OBJECTIVE:\u2002The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo\u2010controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP.<\/jats:p><jats:p>DESIGN:\u2002The degree of lesions before and after treatment scored by a 6\u2010score scale in six cases treated with tazarotene was statistically compared with those of six controls treated with placebo.<\/jats:p><jats:p>SUBJECTS:\u2002Twelve patients with hyperkeratosic OLP were randomly allocated to treatment with tazarotene gel 0.1% b.i.d. or with placebo for eight consecutive weeks.<\/jats:p><jats:p>METHODS:\u2002The statistical comparison was executed by means of Wilcoxon analysis for paired data.<\/jats:p><jats:p>RESULTS:\u2002Patients treated with tazarotene presented a significant reduction of their lesions as compared with the control group. Among transitory side\u2010effects, burning sensation and taste abnormalities were observed.<\/jats:p><jats:p>CONCLUSION:\u2002Topical tazarotene may be a valuable therapeutic tool in the treatment of hyperkeratotic OLP.<\/jats:p>","DOI":"10.1034\/j.1601-0825.2002.02833.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:45:59Z","timestamp":1047483959000},"page":"291-295","source":"Crossref","is-referenced-by-count":44,"title":["Oral lichen planus: a preliminary clinical study on treatment with tazarotene"],"prefix":"10.1111","volume":"8","author":[{"given":"M","family":"Petruzzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"De Benedittis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Vena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Serpico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"337","article-title":"Ongoing clinical study of oral lichen planus (OLP) treated with retinoids: one used locally, (tretinoin) the other orally (etretinate)","volume":"44","author":"Baudet\u2010Pommel M","year":"1990","journal-title":"Actual Odontostomatol (Paris)"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90468-R"},{"key":"e_1_2_6_4_1","first-page":"459","article-title":"Topical tretinoin in the treatment of lichen planus and leukoplakia of the mouth mucosa. 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