{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:33:51Z","timestamp":1774665231599,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2002,11,13]],"date-time":"2002-11-13T00:00:00Z","timestamp":1037145600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>OBJECTIVE:\u2002To investigate the possibility that minor recurrent aphthous stomatitis (MiRAS) is associated with the inheritance of specific gene polymorphisms for markers associated with macrophage driven inflammation, i.e. tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), TNF\u2010<jats:italic>\u03b2<\/jats:italic> or the vitamin D receptor (VDR).<\/jats:p><jats:p>SETTING:\u2002MiRAS is a common, painful, ulcerative condition of the mouth. Its etiology is unknown although mononuclear inflammatory cells are thought to play an important role. There is no clear genetic mode of inheritance, however, many patients report a positive family history and disease concordance is significantly higher in monozygotic than dizygotic twins, suggesting a polygenic mode of inheritance.<\/jats:p><jats:p>METHODS:\u2002Ninety\u2010five MiRAS patients and an ethnically matched control population were genotyped for TNFA\u2010308, TNFB <jats:italic>Nco<\/jats:italic>I and VDR (intron 8 and exon 9) polymorphisms. Chi\u2010square analysis was used to compare the allele frequencies and genotypes of cases and controls.<\/jats:p><jats:p>RESULTS:\u2002No significant association was identified between inheritance of specific alleles or genotypes of the TNFA\u2010308, TNFB <jats:italic>Nco<\/jats:italic>I and VDR (intron 8 and exon 9) polymorphisms and susceptibility to MiRAS.<\/jats:p><jats:p>CONCLUSIONS:\u2002Inheritance of specific gene polymorphisms for TNF\u2010<jats:italic>\u03b1<\/jats:italic>, TNF\u2010<jats:italic>\u03b2<\/jats:italic> or VDR does not appear to be a significant factor in determining susceptibility to MiRAS.<\/jats:p>","DOI":"10.1034\/j.1601-0825.2002.02853.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T15:45:59Z","timestamp":1047483959000},"page":"303-307","source":"Crossref","is-referenced-by-count":16,"title":["Recurrent aphthous stomatitis and gene polymorphisms for the inflammatory markers TNF\u2010<i>\u03b1<\/i>, TNF\u2010<i>\u03b2<\/i> and the vitamin D receptor: no association detected"],"prefix":"10.1111","volume":"8","author":[{"given":"MR","family":"Bazrafshani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AH","family":"Hajeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WER","family":"Ollier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MH","family":"Thornhill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111147"},{"key":"e_1_2_10_3_1","first-page":"1107","article-title":"TNF, soluble IL\u20102R and soluble CD\u20108 in Behcet's disease","volume":"17","author":"Akoglu TF","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358509046497"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00952.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-6-1308"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.827"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1594"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00087.x"},{"key":"e_1_2_10_10_1","first-page":"1428","article-title":"Production of TNF\u2010alpha and IL\u20101 in active Behcet's disease","volume":"17","author":"Hamzaoui K","year":"1990","journal-title":"J Rheumatol"},{"key":"e_1_2_10_11_1","first-page":"222","article-title":"Immune\u2010activation in recurrent oral ulcers (ROU)","volume":"100","author":"Hayrinen\u2010Immonen R","year":"1992","journal-title":"Scand J Dent Res"},{"key":"e_1_2_10_12_1","first-page":"510","article-title":"Immune inflammatory cells in recurrent oral ulcers (ROU)","volume":"99","author":"Hayrinen\u2010Immonen R","year":"1991","journal-title":"Scand J Dent Res"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050360"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705223362103"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700718"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00011-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199708270-00001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1710970307"},{"key":"e_1_2_10_20_1","first-page":"1544","article-title":"Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL\u20108 and increased neutrophil superoxide generation in Behcet's disease. A comparative study with familial Mediterranean fever and healthy subjects","volume":"20","author":"Mege JL","year":"1993","journal-title":"J Rheumatol"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(77)90081-0"},{"key":"e_1_2_10_22_1","first-page":"3084","article-title":"RFLP analysis in the TNF\u2010beta gene and the susceptibility to alloreactive NK cells in Behcet's disease","volume":"33","author":"Mizuki N","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)00159-N"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290104.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jama.1978.03290060031006","article-title":"HLA\u2010Bw51 and Behcet's disease","volume":"240","author":"Ohno S","year":"1978","journal-title":"Jama"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00482.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030401"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6310748"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720120301"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91260-1"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370202"},{"key":"e_1_2_10_32_1","first-page":"321","article-title":"Cytokines in Behcet's disease","volume":"23","author":"Sayinalp N","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb00727.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345650440051501"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90469-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90294-Z"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1980.tb00372.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb00963.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.1999.540307.x"},{"key":"e_1_2_10_41_1","first-page":"118","article-title":"Human lymphocyte antigen (HLA) B51 is more frequent in patients with recurrent aphthous stomatitis (RAS)","volume":"15","author":"Weinberger A","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376825"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1601-0825.2002.02853.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1034%2Fj.1601-0825.2002.02853.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1034\/j.1601-0825.2002.02853.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T20:56:50Z","timestamp":1697576210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1034\/j.1601-0825.2002.02853.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1034\/j.1601-0825.2002.02853.x"],"URL":"https:\/\/doi.org\/10.1034\/j.1601-0825.2002.02853.x","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}