{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T16:42:42Z","timestamp":1698770562771},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,20]],"date-time":"2003-01-20T00:00:00Z","timestamp":1043020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>  <jats:italic>In vivo<\/jats:italic> water assessment would greatly benefit from a dynamical approach since the evaluation of common related variables such as <jats:italic>trans<\/jats:italic>\u2010epidermal water loss or \u201ccapacitance\u201d measurements is always limited to instantaneous data. Mathematical modelling is still an attractive alternative already attempted with bi\u2010exponential empirical models. A classical two\u2010compartment interpretation of such models raises a number of questions about the underlying fundamentals, which can hardly be experimentally confirmed. However, in a system analysis sense, skin water dynamics may be approached as an ensemble of many factors, impossible to discretize, but conceptually grouped in terms of feasible properties of the system. The present paper explores the applicability of this strategy to the <jats:italic>in vivo<\/jats:italic> water dynamics assessment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> From the plastic occlusion stress test (POST) skin water balance is assessed by modelling <jats:italic>trans<\/jats:italic>\u2010epidermal water loss (TEWL) and \u201ccapacitance\u201d data obtained at skin's surface. With system analysis (disposition\u2010decomposition analysis) the distribution function, <jats:italic>H<\/jats:italic>(<jats:italic>t<\/jats:italic>), modelled as a sum of exponential terms, covers only the distribution characteristics of water molecules traversing the skin. This may correspond macroscopically to the experimental data accessed by \u201ccorneometry\u201d. Separately, the hyperbolic elimination function <jats:italic>Q<\/jats:italic>(<jats:styled-content>TEWL<\/jats:styled-content>) helps to characterise the dynamic aspects of water influx through the skin.<\/jats:p><jats:p><jats:bold>Discussion and conclusion:<\/jats:bold> In the observable range there seems to be a linear relationship between the net amount of water lost at the surface by evaporation, and the capability of the system to replenish that loss. This may be a specific characteristic of the system related to what may be described as the skin's \u201cintrinsic hydration capacity\u201d (IHC) a new functional parameter only identified by this strategy. These new quantitative tools are expected to find different applicabilities (from the <jats:italic>in vivo<\/jats:italic> skin characterisation to efficacy testing) contributing to disclose the dynamical nature of the skin water balance process.<\/jats:p>","DOI":"10.1034\/j.1600-0846.2003.0343.x","type":"journal-article","created":{"date-parts":[[2003,3,12]],"date-time":"2003-03-12T20:44:32Z","timestamp":1047501872000},"page":"24-30","source":"Crossref","is-referenced-by-count":12,"title":["Quantitative description of human skin water dynamics by a disposition\u2010decomposition analysis (DDA) of <i>trans<\/i>\u2010epidermal water loss and epidermal capacitance"],"prefix":"10.1111","volume":"9","author":[{"given":"Luis Monteiro","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Contreiras","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Marcelo","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277392"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12507500"},{"key":"e_1_2_6_4_2","first-page":"50","article-title":"Trans\u2010epidermal water loss and skin surface hydration in the non\u2010invasive assessment of the stratum corneum function","volume":"38","author":"Berardesca E","year":"1990","journal-title":"Dermatosen"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000029897"},{"key":"e_1_2_6_6_2","first-page":"Ch. 10","article-title":"A critical approach to in vivo mechanical testing of the skin","author":"Pi\u00e9rard GE.","year":"1989","journal-title":"Cutaneous Investigation in Health and Disease\u201d."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680100089010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2340\/0001555562334337","article-title":"The water\u2010binding capacity of stratum corneum in dry noneczematous skin of atopic eczema","volume":"62","author":"Werner Y","year":"1982","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2340\/0001555570400404"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12507756"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1999.tb00119.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00174.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056341"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2340\/00015555717982","article-title":"The influence of a single application of different moisturisers on skin capacitance","volume":"71","author":"Loden M","year":"1991","journal-title":"Acta Derm Venereol (Stockh)"},{"key":"e_1_2_6_15_2","first-page":"165","volume-title":"Hand Book of Non\u2010Invasive Methods and the Skin","author":"Barel AO","year":"1995"},{"key":"e_1_2_6_16_2","first-page":"161","article-title":"ServoMed Evaporimeter; 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