{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:59:08Z","timestamp":1775743148386,"version":"3.50.1"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[1999,6]]},"DOI":"10.1038\/10039","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:47:57Z","timestamp":1027673277000},"page":"E47-E53","source":"Crossref","is-referenced-by-count":308,"title":["Regulation of the APC and the exit from mitosis"],"prefix":"10.1038","volume":"1","author":[{"given":"David O.","family":"Morgan","sequence":"first","affiliation":[]}],"member":"297","reference":[{"key":"BFncb0699_E47_CR1","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1126\/science.274.5293.1652","volume":"274","author":"RW King","year":"1996","unstructured":"King, R. W., Deshaies, R.J., Peters, J.-M. & Kirschner, M. W. How proteolysis drives the cell cycle. Science 274, 1652\u20131659 (1996).","journal-title":"Science"},{"key":"BFncb0699_E47_CR2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0092-8674(00)80396-7","volume":"91","author":"MA Hoyt","year":"1997","unstructured":"Hoyt, M. A. Eliminating all obstacles: regulated proteolysis in the eukaryotic cell cycle . Cell 91, 149\u2013151 (1997).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0962-8924(98)01268-9","volume":"8","author":"FM Townsley","year":"1998","unstructured":"Townsley, F. M. & Ruderman, J. V. Proteolytic ratchets that control progression through mitosis. Trends Cell Biol. 8, 238\u2013244 ( 1998).","journal-title":"Trends Cell Biol."},{"key":"BFncb0699_E47_CR4","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0955-0674(98)80119-1","volume":"10","author":"J-M Peters","year":"1998","unstructured":"Peters, J.-M. SCF and APC: the yin and yang of cell cycle regulated proteolysis. Curr. Opin. Cell Biol. 10, 759\u2013768 (1998).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb0699_E47_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1146\/annurev.genet.30.1.405","volume":"30","author":"M Hochstrasser","year":"1996","unstructured":"Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405\u2013439 (1996).","journal-title":"Annu. Rev. Genet."},{"key":"BFncb0699_E47_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1091\/mbc.6.2.185","volume":"6","author":"V Sudakin","year":"1995","unstructured":"Sudakin, V. et al. The cyclosome, a large complex containing cyclin-selective ubiquitin-ligase activity, targets cyclins for destruction at the end of mitosis . Mol. Biol. Cell 6, 185\u2013 198 (1995).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0092-8674(95)90338-0","volume":"81","author":"RW King","year":"1995","unstructured":"King, R. W., Peters, J.-M., Tugendreich, S., Rolfe, M., Hieter, P. & Kirschner, M. W. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279\u2013288 ( 1995).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR8","doi-asserted-by":"publisher","first-page":"9303","DOI":"10.1073\/pnas.92.20.9303","volume":"92","author":"S Lahav-Baratz","year":"1995","unstructured":"Lahav-Baratz, S., Sudakin, V., Ruderman, J.V. & Hershko, A. Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc. Natl Acad. Sci. USA 92, 9303 \u20139307 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0699_E47_CR9","doi-asserted-by":"publisher","first-page":"791-801","DOI":"10.1091\/mbc.7.5.791","volume":"7","author":"W Zachariae","year":"1996","unstructured":"Zachariae, W. & Nasmyth, K. TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast. Mol. Biol. Cell 7, 791-801 (1996 ).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0960-9822(98)70201-5","volume":"8","author":"JF Charles","year":"1998","unstructured":"Charles, J. F., Jaspersen, S. L., Tinker-Kulberg, R. L., Hwang, L., Szidon, A. & Morgan, D. O. The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr. Biol. 8, 497\u2013507 ( 1998).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S1097-2765(00)80126-4","volume":"2","author":"G Fang","year":"1998","unstructured":"Fang, G., Yu, H. & Kirschner, M. W. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2, 163\u2013171 (1998).","journal-title":"Mol. Cell"},{"key":"BFncb0699_E47_CR12","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1126\/science.274.5290.1199","volume":"274","author":"J-M Peters","year":"1996","unstructured":"Peters, J.-M., King, R. W., Hoog, C. & Kirschner, M. W. Identification of BIME as a subunit of the anaphase-promoting complex. Science 274, 1199\u20131201 ( 1996).","journal-title":"Science"},{"key":"BFncb0699_E47_CR13","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1126\/science.279.5354.1219","volume":"279","author":"H Yu","year":"1998","unstructured":"Yu, H., Peters, J., King, R. W., Page, A. M., Hieter, P. & Kirschner, M. W. Identification of a cullin homology region in a subunit of the anaphase-promoting complex . Science 279, 1219\u20131222 (1998).","journal-title":"Science"},{"key":"BFncb0699_E47_CR14","unstructured":"Grossberger, R. et al. Characterization of the DOC1\/APC10 subunit of the yeast and the human anaphase-promoting complex. J. Biol. Chem. (in the press)."},{"key":"BFncb0699_E47_CR15","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0092-8674(95)90337-2","volume":"81","author":"S Irniger","year":"1995","unstructured":"Irniger, S., Piatti, S., Michaelis, C. & Nasmyth, K. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81, 269 \u2013277 (1995).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR16","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1126\/science.274.5290.1201","volume":"274","author":"W Zachariae","year":"1996","unstructured":"Zachariae, W., Shin, T.H., Galova, M., Obermaier, B. & Nasmyth, K. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274, 1201\u20131204 (1996).","journal-title":"Science"},{"key":"BFncb0699_E47_CR17","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1093\/emboj\/17.2.498","volume":"17","author":"KM Kramer","year":"1998","unstructured":"Kramer, K. M., Fesquet, D., Johnson, A. L. & Johnston, L. H. Budding yeast RSI1\/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit. EMBO J. 17, 498\u2013 505 (1998).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR18","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1091\/mbc.8.10.1877","volume":"8","author":"LH Hwang","year":"1997","unstructured":"Hwang, L. H. & Murray, A. W. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis . Mol. Biol. Cell 8, 1877\u2013 1887 (1997).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR19","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.279.5354.1216","volume":"279","author":"W Zachariae","year":"1998","unstructured":"Zachariae, W. et al. Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279, 1216\u20131219 ( 1998).","journal-title":"Science"},{"key":"BFncb0699_E47_CR20","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1126\/science.278.5337.460","volume":"278","author":"R Visintin","year":"1997","unstructured":"Visintin, R., Prinz, S. & Amon, A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460\u2013 463 (1997).","journal-title":"Science"},{"key":"BFncb0699_E47_CR21","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0092-8674(00)80529-2","volume":"90","author":"M Schwab","year":"1997","unstructured":"Schwab, M., Lutum, A.S. & Seufert, W. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis . Cell 90, 683\u2013693 (1997).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1083\/jcb.129.3.725","volume":"129","author":"IA Dawson","year":"1995","unstructured":"Dawson, I. A., Roth, S. & Artavanis-Tsakonas, S. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129, 725\u2013737 (1995).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR23","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1002\/j.1460-2075.1995.tb00164.x","volume":"14","author":"S Sigrist","year":"1995","unstructured":"Sigrist, S., Jacobs, J., Stratmann, R. & Lehner, C. F. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B, and B3. EMBO J. 14, 4827 \u20134838 (1995).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR24","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0092-8674(00)80528-0","volume":"90","author":"SJ Sigrist","year":"1997","unstructured":"Sigrist, S. J. & Lehner, C. F. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671\u2013681 (1997).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR25","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1093\/emboj\/17.13.3565","volume":"17","author":"T Lorca","year":"1998","unstructured":"Lorca, T., et al. Fizzy is required for activation of the APC\/cyclosome in Xenopus egg extracts. EMBO J. 17, 3565 \u20133575 (1998).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR26","doi-asserted-by":"publisher","first-page":"28501","DOI":"10.1074\/jbc.272.45.28501","volume":"272","author":"J Weinstein","year":"1997","unstructured":"Weinstein, J. Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc . J. Biol. Chem. 272, 28501\u2013 28511 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFncb0699_E47_CR27","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/S0960-9822(07)00510-6","volume":"8","author":"ER Kramer","year":"1998","unstructured":"Kramer, E. R., Gieffers, C., Holzl, G., Hengstschlager, M. & Peters, J.-M. Activation of the human anaphase promoting complex by proteins of the CDC20\/Fizzy family. Curr. Biol. 8, 1207\u20131210 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR28","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1126\/science.279.5353.1045","volume":"279","author":"SH Kim","year":"1998","unstructured":"Kim, S. H., Lin, D. P., Matsumoto, S., Kitazono, A. & Matsumoto, T. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science 279 , 1045\u20131047 (1998).","journal-title":"Science"},{"key":"BFncb0699_E47_CR29","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1091\/mbc.9.5.1065","volume":"9","author":"K Kitamura","year":"1998","unstructured":"Kitamura, K., Maekawa, H. & Shimoda, C. Fission yeast Ste9, a homolog of Hct1\/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase. Mol. Biol. Cell 9, 1065\u20131080 (1998).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR30","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1091\/mbc.8.12.2475","volume":"8","author":"S Yamaguchi","year":"1997","unstructured":"Yamaguchi, S., Murakami, H. & Okayama, H. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2\/B-type cyclin complexes. Mol. Biol. Cell 8, 2475\u20132486 ( 1997).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR31","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1126\/science.282.5394.1721","volume":"282","author":"W Zachariae","year":"1998","unstructured":"Zachariae, W., Schwab, M., Nasmyth, K. & Seufert, W. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the Anaphase Promoting Complex. Science 282, 1721\u2013 1724 (1998).","journal-title":"Science"},{"key":"BFncb0699_E47_CR32","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S0960-9822(98)70088-0","volume":"8","author":"HH Lim","year":"1998","unstructured":"Lim, H. H., Goh, P. & Surana, U. Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr. Biol. 8 , 231\u2013234 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR33","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/emboj\/17.5.1336","volume":"17","author":"M Shirayama","year":"1998","unstructured":"Shirayama, M., Zachariae, W., Ciosk, R. & Nasmyth, K. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p\/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 17, 1336\u20131349 ( 1998).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR34","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0960-9822(99)80111-0","volume":"9","author":"SL Jaspersen","year":"1999","unstructured":"Jaspersen, S. L., Charles, J. F. & Morgan, D. O. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227\u2013236 ( 1999).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR35","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.1101\/gad.10.24.3081","volume":"10","author":"O Cohen-Fix","year":"1996","unstructured":"Cohen-Fix, O., Peters, J.-M., Kirschner, M. W. & Koshland, D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10, 3081\u20133093 ( 1996).","journal-title":"Genes Dev."},{"key":"BFncb0699_E47_CR36","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/381438a0","volume":"381","author":"H Funabiki","year":"1996","unstructured":"Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T. & Yanagida, M. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438\u2013441 ( 1996).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR37","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0092-8674(00)81211-8","volume":"93","author":"R Ciosk","year":"1998","unstructured":"Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M. & Nasmyth, K. An ESP1\/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93, 1067\u20131076 ( 1998).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR38","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S0960-9822(98)70250-7","volume":"8","author":"K Kumada","year":"1998","unstructured":"Kumada, K., Nakamura, T., Nagao, K., Funabiki, H., Nakagawa, T. & Yanagida, M. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis. Curr. Biol. 8, 633\u2013641 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1083\/jcb.133.1.99","volume":"133","author":"A Yamamoto","year":"1996","unstructured":"Yamamoto, A., Guacci, V. & Koshland, D. Pds1, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133, 99\u2013110 ( 1996).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR40","unstructured":"Alexandru, G., Zachariae, W., Toth, A. & Nasmyth, K. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage. EMBO J. (in the press)."},{"key":"BFncb0699_E47_CR41","doi-asserted-by":"publisher","first-page":"6617","DOI":"10.1002\/j.1460-2075.1996.tb01052.x","volume":"15","author":"H Funabiki","year":"1996","unstructured":"Funabiki, H., Kumada, K. & Yanagida, M. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J. 15, 6617\u2013 6628 (1996).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR42","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/344503a0","volume":"344","author":"P Nurse","year":"1990","unstructured":"Nurse, P. Universal control mechanism regulating onset of M-phase. Nature 344, 503\u2013508 ( 1990).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR43","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/0962-8924(94)90142-2","volume":"4","author":"WG Dunphy","year":"1994","unstructured":"Dunphy, W.G. The decision to enter mitosis. Trends Cell Biol. 4, 202\u2013207 (1994).","journal-title":"Trends Cell Biol."},{"key":"BFncb0699_E47_CR44","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/0092-8674(94)90542-8","volume":"79","author":"RW King","year":"1994","unstructured":"King, R. W., Jackson, P. K. & Kirschner, M. W. Mitosis in transition. Cell 79, 563\u2013571 (1994).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev.cellbio.13.1.261","volume":"13","author":"DO Morgan","year":"1997","unstructured":"Morgan, D. O. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261\u2013 291 (1997).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BFncb0699_E47_CR46","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/339280a0","volume":"339","author":"AW Murray","year":"1989","unstructured":"Murray, A. W., Solomon, M. & Kirschner, M. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339, 280\u2013286 (1989).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR47","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1083\/jcb.117.1.213","volume":"117","author":"P Gallant","year":"1992","unstructured":"Gallant, P. & Nigg, E. A. Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J. Cell Biol. 117, 213\u2013224 (1992).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR48","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/0092-8674(93)90364-V","volume":"73","author":"SL Holloway","year":"1993","unstructured":"Holloway, S. L., Glotzer, M., King, R. W. & Murray, A. W. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73, 1393\u20131402 (1993).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR49","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1002\/j.1460-2075.1993.tb05846.x","volume":"12","author":"U Surana","year":"1993","unstructured":"Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B. & Nasmyth, K. Destruction of the CDC28\/CLB mitotic kinase is not required for the metaphase-to-anaphase transition in budding yeast. EMBO J. 12, 1969\u20131978 (1993).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR50","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1242\/jcs.107.10.2729","volume":"107","author":"G Rimmington","year":"1994","unstructured":"Rimmington, G., Dalby, B. & Glover, D. M. Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase. J. Cell Sci. 107, 2729\u20132738 (1994).","journal-title":"J. Cell Sci."},{"key":"BFncb0699_E47_CR51","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/S0960-9822(98)70298-2","volume":"8","author":"S Prinz","year":"1998","unstructured":"Prinz, S., Hwang, E. S., Visintin, R. & Amon, A. The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr. Biol. 8, 750\u2013760 (1998).","journal-title":"Curr. Biol."},{"key":"BFncb0699_E47_CR52","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/10049","volume":"1","author":"P Clute","year":"1999","unstructured":"Clute, P. & Pines, J. Temporal and spatial regulation of cyclin B1 destruction in metaphase. Nature Cell Biol. 1, 82\u201387 (1999).","journal-title":"Nature Cell Biol."},{"key":"BFncb0699_E47_CR53","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1002\/j.1460-2075.1990.tb07476.x","volume":"9","author":"J Minshull","year":"1990","unstructured":"Minshull, J., Golsteyn, R., Hill, C. S. & Hunt, T. The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J. 9, 2865\u20132875 (1990).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1083\/jcb.115.1.1","volume":"115","author":"J Pines","year":"1991","unstructured":"Pines, J. & Hunter, T. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J. Cell. Biol. 115, 1\u201317 (1991).","journal-title":"J. Cell. Biol."},{"key":"BFncb0699_E47_CR55","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0092-8674(95)90336-4","volume":"81","author":"S Tugendreich","year":"1995","unstructured":"Tugendreich, S., Tonkiel, J., Earnshaw, W. & Hieter, P. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell 81, 261\u2013268 (1995).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR56","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1128\/MCB.18.1.468","volume":"18","author":"P-M J\u00f6rgensen","year":"1998","unstructured":"J\u00f6rgensen, P.-M., Brundell, E., Starborg, M. & H\u00f6\u00f6g, C. A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells. Mol. Cell. Biol. 18, 468\u2013476 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb0699_E47_CR57","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1083\/jcb.141.6.1393","volume":"141","author":"M Kallio","year":"1998","unstructured":"Kallio, M., Weinstein, J., Daum, J. R., Burke, D. J. & Gorbsky, G. J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome\/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events . J. Cell Biol. 141, 1393\u2013 1406 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR58","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1101\/gad.12.10.1495","volume":"12","author":"TT Su","year":"1998","unstructured":"Su, T. T., Sprenger, F., DiGregorio, P. J., Campbell, S. D. & O\u2019Farrell, P. H. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 12, 1495\u20131503 (1998).","journal-title":"Genes Dev."},{"key":"BFncb0699_E47_CR59","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/emboj\/18.8.2184","volume":"18","author":"J Huang","year":"1999","unstructured":"Huang, J. & Raff, J. The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 18, 2184\u20132195 ( 1999).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR60","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/346379a0","volume":"346","author":"M-A Felix","year":"1990","unstructured":"Felix, M.-A., Labbe, J.-C., Doree, M., Hunt, T. & Karsenti, E. Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase. Nature 346, 379\u2013382 (1990).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR61","doi-asserted-by":"publisher","first-page":"12431","DOI":"10.1073\/pnas.94.23.12431","volume":"94","author":"Y Li","year":"1997","unstructured":"Li, Y., Gorbea, C., Mahaffey, D., Rechsteiner, M. & Benezra, R. MAD2 associates with the cyclosome\/anaphase-promoting complex and inhibits its activity. Proc. Natl Acad. Sci. USA 94, 12431\u201312436 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0699_E47_CR62","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S1097-2765(00)80037-4","volume":"1","author":"S Kotani","year":"1998","unstructured":"Kotani, S. et al. PKA and MPF-activated Polo-like kinase regulate Anaphase-Promoting Complex activity and mitosis progression. Mol. Cell 1, 371\u2013380 (1998).","journal-title":"Mol. Cell"},{"key":"BFncb0699_E47_CR63","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1101\/gad.12.16.2549","volume":"12","author":"D Patra","year":"1998","unstructured":"Patra, D. & Dunphy, W. G. Xe-p9, a Xenopus Suc1\/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis. Genes Dev. 12, 2549\u2013 2559 (1998).","journal-title":"Genes Dev."},{"key":"BFncb0699_E47_CR64","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1126\/science.274.5293.1664","volume":"274","author":"SJ Elledge","year":"1996","unstructured":"Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664\u20131672 ( 1996).","journal-title":"Science"},{"key":"BFncb0699_E47_CR65","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0955-0674(96)80077-9","volume":"8","author":"AD Rudner","year":"1996","unstructured":"Rudner, A. D. & Murray, A. W. The spindle assembly checkpoint . Curr. Opin. Cell Biol. 8, 773\u2013 780 (1996).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb0699_E47_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-9525(97)01340-1","volume":"14","author":"KG Hardwick","year":"1998","unstructured":"Hardwick, K. G. The spindle checkpoint. Trends Genet. 14, 1\u20134 (1998).","journal-title":"Trends Genet."},{"key":"BFncb0699_E47_CR67","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1126\/science.279.5353.1041","volume":"279","author":"LH Hwang","year":"1998","unstructured":"Hwang, L. H. et al. Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041\u20131044 ( 1998).","journal-title":"Science"},{"key":"BFncb0699_E47_CR68","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1101\/gad.12.12.1871","volume":"12","author":"G Fang","year":"1998","unstructured":"Fang, G., Yu, H. & Kirschner, M. W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12, 1871 \u20131883 (1998).","journal-title":"Genes Dev."},{"key":"BFncb0699_E47_CR69","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.274.5285.242","volume":"274","author":"R-H Chen","year":"1996","unstructured":"Chen, R.-H., Waters, J.-C., Salmon, E. D. & Murray, A. W. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274, 242\u2013 246 (1996).","journal-title":"Science"},{"key":"BFncb0699_E47_CR70","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0092-8674(00)80255-X","volume":"89","author":"SS Taylor","year":"1997","unstructured":"Taylor, S. S. & McKeon, F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89, 727\u2013735 (1997).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR71","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1083\/jcb.141.5.1181","volume":"141","author":"JC Waters","year":"1998","unstructured":"Waters, J. C., Chen, R.-H., Murray, A. W. & Salmon, E. D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141, 1181\u2013 1191 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR72","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1083\/jcb.141.5.1193","volume":"141","author":"GJ Gorbsky","year":"1998","unstructured":"Gorbsky, G. J., Chen, R.-H. & Murray, A. W. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell. Biol. 141, 1193\u20131205 (1998).","journal-title":"J. Cell. Biol."},{"key":"BFncb0699_E47_CR73","doi-asserted-by":"publisher","first-page":"14361","DOI":"10.1073\/pnas.94.26.14361","volume":"94","author":"O Cohen-Fix","year":"1997","unstructured":"Cohen-Fix, O. & Koshland, D. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. Proc. Natl Acad. Sci. USA 94, 14361\u2013 14366 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0699_E47_CR74","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1093\/emboj\/16.10.2693","volume":"16","author":"A Amon","year":"1997","unstructured":"Amon, A. Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast. EMBO J. 16, 2693\u2013 2702 (1997).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR75","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/0092-8674(91)90118-I","volume":"66","author":"T Moll","year":"1991","unstructured":"Moll, T., Tebb, G., Surana, U., Robitsch, H. & Nasmyth, K. The role of phosphorylation and the CDC28 protein kinase in the cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66, 743\u2013 758 (1991).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR76","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.1128\/MCB.16.10.5701","volume":"16","author":"D Knapp","year":"1996","unstructured":"Knapp, D., Bhoite, L., Stillman, D. J. & Nasmyth, K. The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1. Mol. Cell. Biol. 16, 5701\u20135707 (1996).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb0699_E47_CR77","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/genetics\/145.1.85","volume":"145","author":"JH Toyn","year":"1996","unstructured":"Toyn, J. H., Johnson, A. L., Donovan, J. D., Toone, W. M. & Johnston, L. H. The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the Cdk-inhibitor Sic1 in telophase. Genetics 145 , 85\u201396 (1996).","journal-title":"Genetics"},{"key":"BFncb0699_E47_CR78","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1126\/science.278.5337.455","volume":"278,","author":"R Verma","year":"1997","unstructured":"Verma, R., Annan, R. S., Huddleston, M. J., Carr, S. A., Reynard, G. & Deshaies, R. J. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455\u2013460 (1997).","journal-title":"Science"},{"key":"BFncb0699_E47_CR79","unstructured":"Fesquet, D., Fitzpatrick, P. J., Johnson, A. L., Kramer, K. M., Toyn, J. H. & Johnston, L. H. A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2 kinase in budding yeast. EMBO J. (in the press)."},{"key":"BFncb0699_E47_CR80","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1073\/pnas.96.9.4989","volume":"96","author":"R Li","year":"1999","unstructured":"Li, R. Bifurcation of the mitotic checkpoint pathway in budding yeast. Proc. Natl Acad. Sci. USA 96, 4989\u20134994 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb0699_E47_CR81","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/yea.320070308","volume":"7","author":"B Schweitzer","year":"1991","unstructured":"Schweitzer, B. & Philippsen, P. CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain . Yeast 7, 265\u2013273 (1991).","journal-title":"Yeast"},{"key":"BFncb0699_E47_CR82","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1128\/MCB.10.4.1358","volume":"10","author":"LH Johnston","year":"1990","unstructured":"Johnston, L. H., Eberly, S. L., Chapman, J. W., Araki, H. & Sugino, A. The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle. Mol. Cell. Biol. 10, 1358\u20131366 ( 1990).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb0699_E47_CR83","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1128\/MCB.13.7.4445","volume":"13","author":"K Kitada","year":"1993","unstructured":"Kitada, K., Johnson, A. L., Johnston, L. H. & Sugino, A. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol. 13, 4445\u2013 4457 (1993).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb0699_E47_CR84","doi-asserted-by":"crossref","first-page":"11274","DOI":"10.1016\/S0021-9258(19)49907-9","volume":"267","author":"J Wan","year":"1992","unstructured":"Wan, J., Xu, H. & Grunstein, M. CDC14 of Saccharomyces cerevisiae. J. Biol. Chem. 267, 11274\u201311280 (1992).","journal-title":"J. Biol. Chem."},{"key":"BFncb0699_E47_CR85","doi-asserted-by":"publisher","first-page":"24054","DOI":"10.1074\/jbc.272.38.24054","volume":"272","author":"GS Taylor","year":"1997","unstructured":"Taylor, G. S., Liu, Y., Baskerville, C. & Charbonneau, H. The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J. Biol. Chem. 272, 24054\u201324063 ( 1997).","journal-title":"J. Biol. Chem."},{"key":"BFncb0699_E47_CR86","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/yea.320100404","volume":"10","author":"M Shirayama","year":"1994","unstructured":"Shirayama, M., Matsui, Y., Tanaka, K. & Toh-e, A. Isolation of a CDC25 family gene, MSI2\/LTE1, as a multicopy suppressor of ira1. Yeast 10, 451\u2013461 ( 1994).","journal-title":"Yeast"},{"key":"BFncb0699_E47_CR87","doi-asserted-by":"publisher","first-page":"7476","DOI":"10.1128\/MCB.14.11.7476","volume":"14","author":"M Shirayama","year":"1994","unstructured":"Shirayama, M., Matsui, Y. & Toh-e, A. The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol. Cell. Biol. 14, 7476\u20137482 ( 1994).","journal-title":"Mol. Cell. Biol."},{"key":"BFncb0699_E47_CR88","first-page":"176","volume":"251","author":"M Shirayama","year":"1996","unstructured":"Shirayama, M., Matsui, Y. & Toh-e, A. Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14. Mol. Gen. Genet. 251, 176\u2013185 (1996).","journal-title":"Mol. Gen. Genet."},{"key":"BFncb0699_E47_CR89","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1091\/mbc.9.1.29","volume":"9","author":"FC Luca","year":"1998","unstructured":"Luca, F. C. & Winey, M. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol. Biol. Cell 9, 29\u201346 ( 1998).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR90","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1091\/mbc.9.10.2803","volume":"9","author":"SL Jaspersen","year":"1998","unstructured":"Jaspersen, S. L., Charles, J. F., Tinker-Kulberg, R. L. & Morgan, D. O. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803\u2013 2817 (1998).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb0699_E47_CR91","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S1097-2765(00)80286-5","volume":"2","author":"R Visintin","year":"1998","unstructured":"Visintin, R., Craig, K., Hwang, E. S., Prinz, S., Tyers, M. & Amon, A. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709\u2013718 ( 1998).","journal-title":"Mol. Cell"},{"key":"BFncb0699_E47_CR92","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0092-8674(00)80733-3","volume":"97","author":"W Shou","year":"1999","unstructured":"Shou, W. et al. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233\u2013244 (1999).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR93","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0092-8674(00)80734-5","volume":"97","author":"AF Straight","year":"1999","unstructured":"Straight, A. F., Shou, W., Dowd, G. J., Turck, C. W., Deshaies, R. J., Johnson, A. D. & Moazed, D. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97, 245\u2013256 ( 1999).","journal-title":"Cell"},{"key":"BFncb0699_E47_CR94","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/19775","volume":"398","author":"R Visintin","year":"1999","unstructured":"Visintin, R., Hwang, E. S. & Amon, A. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398, 818\u2013823 (1999).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR95","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/S0955-0674(98)80121-X","volume":"10","author":"EA Nigg","year":"1998","unstructured":"Nigg, E.A. Polo-like kinases: positive regulators of cell division from start to finish . Curr. Opin. Cell Biol. 10, 776\u2013 783 (1998).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb0699_E47_CR96","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1083\/jcb.135.6.1701","volume":"135","author":"HA Lane","year":"1996","unstructured":"Lane, H. A. & Nigg, E. A. Antibody microinjection reveals an essential role for human Polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J. Cell Biol. 135, 1701\u20131713 (1996).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/jcs.89.1.25","volume":"89","author":"CE Sunkel","year":"1988","unstructured":"Sunkel, C. E. & Glover, D. M. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci. 89, 25\u201338 ( 1988).","journal-title":"J. Cell Sci."},{"key":"BFncb0699_E47_CR98","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1101\/gad.9.9.1059","volume":"9","author":"H Ohkura","year":"1995","unstructured":"Ohkura, H., Hagan, I. M. & Glover, D. M. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 9, 1059\u20131073 (1995).","journal-title":"Genes Dev."},{"key":"BFncb0699_E47_CR99","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1083\/jcb.143.3.659","volume":"143","author":"M Carmena","year":"1998","unstructured":"Carmena, M., Riparbelli, M. G., Minestrini, G., Tavares, A. M., Adams, R., Callaini, G. & Glover, D. M. Drosophila Polo kinase is required for cytokinesis. J. Cell Biol. 143 , 659\u2013671 (1998).","journal-title":"J. Cell Biol."},{"key":"BFncb0699_E47_CR100","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1093\/emboj\/17.5.1328","volume":"17","author":"P Descombes","year":"1998","unstructured":"Descombes, P. & Nigg, E. A. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J. 17, 1328\u20131335 (1998).","journal-title":"EMBO J."},{"key":"BFncb0699_E47_CR101","unstructured":"Pines, J. Four-dimensional control of the cell cycle. Nature Cell Biol. (in the press)."},{"key":"BFncb0699_E47_CR102","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/43199","volume":"387","author":"N Barkai","year":"1997","unstructured":"Barkai, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913\u2013 917 (1997).","journal-title":"Nature"},{"key":"BFncb0699_E47_CR103","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/16483","volume":"397","author":"U Alon","year":"1999","unstructured":"Alon, U., Surette, M. G., Barkai, N. & Leibler, S. Robustness in bacterial chemotaxis. Nature 397, 168\u2013171(1999).","journal-title":"Nature"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb0699_E47.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0699_E47","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb0699_E47.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:18:06Z","timestamp":1638404286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb0699_E47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["BFncb0699_E47"],"URL":"https:\/\/doi.org\/10.1038\/10039","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}