{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:57:55Z","timestamp":1791939475606,"version":"4.3.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1038\/10518","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:33Z","timestamp":1027673013000},"page":"793-802","source":"Crossref","is-referenced-by-count":671,"title":["Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis"],"prefix":"10.1038","volume":"5","author":[{"given":"Israel","family":"Vlodavsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Friedmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Elkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Aingorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Atzmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivka","family":"Ishai-Michaeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menachem","family":"Bitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Pappo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuvia","family":"Peretz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Michal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Pecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"BFnm0799793_CR1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev.bi.60.070191.002303","volume":"60","author":"L Kjellen","year":"1991","unstructured":"Kjellen, L. & Lindahl, U. Proteoglycans: structures and interactions. Annu. Rev. Biochem. 60, 443\u2013 475 (1991).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnm0799793_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1096\/fasebj.7.11.8370471","volume":"7","author":"G David","year":"1993","unstructured":"David, G. Integral membrane heparan sulfate proteoglycan. FASEB J. 7, 1023\u20131030 (1993).","journal-title":"FASEB J."},{"key":"BFnm0799793_CR3","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1152\/physrev.1991.71.2.481","volume":"71","author":"RL Jackson","year":"1991","unstructured":"Jackson, R.L., Busch, S.J. & Cardin, A.L. Glycosaminoglycans: Molecular properties, protein interactions and role in physiological processes. Physiol. Rev. 71, 481\u2013539 (1991).","journal-title":"Physiol. Rev."},{"key":"BFnm0799793_CR4","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/0955-0674(92)90102-I","volume":"4","author":"TN Wight","year":"1992","unstructured":"Wight, T.N., Kinsella, M.G. & Qwarnstromn, E.E. The role of proteoglycans in cell adhesion, migration and proliferation. Curr. Opin. Cell Biol. 4, 793\u2013801 (1992).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnm0799793_CR5","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/0955-0674(93)90034-N","volume":"5","author":"AC Rapraeger","year":"1993","unstructured":"Rapraeger, A.C. The coordinated regulation of heparan sulfate, syndecans and cell behavior. Curr. Opin. Cell Biol. 5, 844\u2013 853 (1993).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnm0799793_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.ATV.9.1.1","volume":"9","author":"TN Wight","year":"1989","unstructured":"Wight, T.N. Cell biology of arterial proteoglycans. Arteriosclerosis 9, 1\u201320 (1989).","journal-title":"Arteriosclerosis"},{"key":"BFnm0799793_CR7","first-page":"2704","volume":"43","author":"I Vlodavsky","year":"1983","unstructured":"Vlodavsky, I., Fuks, Z., Bar-Ner, M., Ariav, Y. & Schirrmacher, V. Lymphoma cell mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: Relationship to tumor cell metastasis. Cancer Res. 43, 2704\u20132711 (1983).","journal-title":"Cancer Res."},{"key":"BFnm0799793_CR8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1126\/science.6220468","volume":"220","author":"M Nakajima","year":"1983","unstructured":"Nakajima, M., Irimura, T., DiFerrante, D., DiFerrante, N. & Nicholson, G.L. Heparan sulfate degradation: relation to tumor invasion and metastatic properties of mouse B16 melanoma sublines. Science 220, 611\u2013 613 (1983).","journal-title":"Science"},{"key":"BFnm0799793_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/jcb.240360207","volume":"36","author":"M Nakajima","year":"1988","unstructured":"Nakajima, M., Irimura, T. & Nicolson, G.L. Heparanase and tumor metastasis. J. Cell. Biochem. 36, 157\u2013167 (1988).","journal-title":"J. Cell. Biochem."},{"key":"BFnm0799793_CR10","first-page":"290","volume":"14","author":"I Vlodavsky","year":"1995","unstructured":"Vlodavsky, I. et al. Inhibition of tumor metastasis by heparanase inhibiting species of heparin. Invasion Metastasis 14, 290\u2013 302 (1995).","journal-title":"Invasion Metastasis"},{"key":"BFnm0799793_CR11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/ijc.2910400414","volume":"40","author":"CR Parish","year":"1987","unstructured":"Parish, C.R., Coombe, D.R., Jakobsen, K.B. & Underwood, P.A. Evidence that sulphated polysaccharides inhibit tumor metastasis by blocking tumor cell-derived heparanase. Int. J. Cancer 40, 511\u2013517 (1987).","journal-title":"Int. J. Cancer"},{"key":"BFnm0799793_CR12","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1172\/JCI113953","volume":"83","author":"O Lider","year":"1989","unstructured":"Lider, O. et al. Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with heparinoid inhibitors of T lymphocyte heparanase. J. Clin. Invest. 83, 752\u2013756 (1989).","journal-title":"J. Clin. Invest."},{"key":"BFnm0799793_CR13","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.4049\/jimmunol.140.10.3401","volume":"140","author":"DO Willenborg","year":"1988","unstructured":"Willenborg, D. O. & Parish, C. R. Inhibition of allergic encephalomyelitis in rats by treatment with sulfated polysaccharides. J. Immunol. 140, 3401\u2013 3405 (1988).","journal-title":"J. Immunol."},{"key":"BFnm0799793_CR14","first-page":"112","volume":"12,","author":"I Vlodavsky","year":"1992","unstructured":"Vlodavsky, I. et al. Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation. Invasion Metastasis 12, 112\u2013 127 (1992).","journal-title":"Invasion Metastasis"},{"key":"BFnm0799793_CR15","first-page":"563","volume":"39","author":"LD Graham","year":"1996","unstructured":"Graham, L.D. & Underwood, P.A. Comparison of the heparanase enzymes from mouse melanoma cells, mouse macrophages and human platelets. Biochem. Mol. Biol. 39, 563\u2013 571 (1996).","journal-title":"Biochem. Mol. Biol."},{"key":"BFnm0799793_CR16","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1091\/mbc.1.11.833","volume":"1","author":"R Ishai-Michaeli","year":"1990","unstructured":"Ishai-Michaeli, R., Eldor, A. & Vlodavsky, I. Heparanase activity expressed by platelets, neutrophils and lymphoma cells releases active fibroblast growth factor from extracellular matrix. Cell Reg. 1, 833\u2013 842 (1990).","journal-title":"Cell Reg."},{"key":"BFnm0799793_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/0968-0004(91)90102-2","volume":"16","author":"I Vlodavsky","year":"1991","unstructured":"Vlodavsky, I., Bar-Shavit, R., Ishai-Michaeli, R., Bashkin, P. & Fuks, Z. Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? Trends Biochem. Sci. 16, 268\u2013271 (1991).","journal-title":"Trends Biochem. Sci."},{"key":"BFnm0799793_CR18","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1172\/JCI116081","volume":"90","author":"S Eisenberg","year":"1992","unstructured":"Eisenberg, S., Sehayek, E., Olivecrona, T. & Vlodavsky, I. Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix. J. Clin. Invest. 90, 2013\u20132021 (1992).","journal-title":"J. Clin. Invest."},{"key":"BFnm0799793_CR19","doi-asserted-by":"crossref","first-page":"11249","DOI":"10.1016\/S0021-9258(18)33749-9","volume":"257","author":"GM Oosta","year":"1982","unstructured":"Oosta, G.M., Favreau, L.V., Beeler, D.L. & Rosenberg, R.D. Purification and properties of human platelet heparitinase. J. Biol. Chem. 257, 11249\u201311255 (1982).","journal-title":"J. Biol. Chem."},{"key":"BFnm0799793_CR20","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1042\/bj3301341","volume":"330","author":"C Freeman","year":"1998","unstructured":"Freeman, C. & Parish, C.R. Human platelet heparanase: Purification, characterization and catalytic activity. Biochem. J. 330, 1341\u20131350 (1998).","journal-title":"Biochem. J."},{"key":"BFnm0799793_CR21","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1074\/jbc.270.7.3268","volume":"270","author":"AJ Hoogewerf","year":"1995","unstructured":"Hoogewerf, A.J. et al. CXC chemokines connective tissue activating peptide-III and neutrophil activating peptide-2 are heparin\/heparan sulfate-degrading enzymes. J. Biol. Chem. 270, 3268\u2013 3277 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFnm0799793_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0167-4838(98)00254-4","volume":"1429","author":"V Gonzalo","year":"1999","unstructured":"Gonzalo, V. et al. Partial sequence of human platelet heparitinase and evidence of its ability to polymerize. Biochim. Biophys. Acta 1429, 431\u2013438 (1999).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnm0799793_CR23","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1002\/ijc.2910450618","volume":"45","author":"L Jin","year":"1990","unstructured":"Jin, L., Nakajima, M. & Nicolson, G.L. Immunochemical localization of heparanase in mouse and human melanoma. Int. J. Cancer 45, 1088\u20131095 (1990).","journal-title":"Int. J. Cancer"},{"key":"BFnm0799793_CR24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/ijc.2910560224","volume":"56","author":"MW De Vouge","year":"1994","unstructured":"De Vouge, M.W. et al. Immunoselection of GRP94\/Endoplasmin from a KNRK cell specific g gt11 library using antibodies directed against a putative heparanase amino-terminal peptide. Int. J. Cancer 56, 286\u2013 294 (1994).","journal-title":"Int. J. Cancer"},{"key":"BFnm0799793_CR25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1093\/molehr\/2.9.679","volume":"2","author":"R Goshen","year":"1996","unstructured":"Goshen, R. et al. Purification and characterization of placental heparanase and its expression by cultured cytotrophoblasts. Mol. Hum. Reprod. 2, 679\u2013684 (1996).","journal-title":"Mol. Hum. Reprod."},{"key":"BFnm0799793_CR26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1182\/blood.V70.2.551.551","volume":"70","author":"M Bar-Ner","year":"1987","unstructured":"Bar-Ner, M., Eldor, A., Wasserman, L., Matzner, Y. & Vlodavsky, I. Inhibition of heparanase mediated degradation of extracellular matrix heparan sulfate by modified and non-anticoagulant heparin species. Blood 70, 551\u2013557 (1987).","journal-title":"Blood"},{"key":"BFnm0799793_CR27","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nm0898-909","volume":"8","author":"S Even-Ram","year":"1998","unstructured":"Even-Ram, S. et al. Thrombin receptor overexpression in malignant and physiological invasion processes. Nature Med. 8, 909\u2013 914 (1998).","journal-title":"Nature Med."},{"key":"BFnm0799793_CR28","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1084\/jem.160.5.1579","volume":"160","author":"L Larizza","year":"1984","unstructured":"Larizza, L., Schirrmacher, V. & Pfluger, E. Acquisition of high metastatic capacity after in vitro fusion of a non-metastatic tumor line with a bone marrow derived macrophage. J. Exp. Med. 160, 1579\u2013 1584 (1984).","journal-title":"J. Exp. Med."},{"key":"BFnm0799793_CR29","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1515\/bchm2.1979.360.2.1465","volume":"360","author":"U Klein","year":"1979","unstructured":"Klein, U. & Figura, K.V. Substrate specificity of a heparan-sulfate degrading endoglucuronidase from human placenta. Hoppe-Seyler's Z Physiol. Chem. 360, 1465\u20131471 (1979).","journal-title":"Hoppe-Seyler's Z Physiol. Chem."},{"key":"BFnm0799793_CR30","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1074\/jbc.272.4.2245","volume":"272","author":"KJ Bame","year":"1997","unstructured":"Bame, K. J., & Robson K. Heparanases produce distinct populations of heparan sulfate glycosaminoglycans in Chinese hamster ovary cells. J. Biol. Chem. 272, 2245\u20132251 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm0799793_CR31","doi-asserted-by":"publisher","first-page":"18770","DOI":"10.1074\/jbc.273.30.18770","volume":"273","author":"D Sandback-Pikas","year":"1998","unstructured":"Sandback-Pikas, D., Li, J-P., Vlodavsky, I. & Lindahl, U. Substrate specificity of heparanases from human hepatoma and platelets. J. Biol. Chem. 273, 18770\u201318777 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFnm0799793_CR32","doi-asserted-by":"publisher","first-page":"15753","DOI":"10.1074\/jbc.272.25.15753","volume":"272","author":"S Pillarisetti","year":"1997","unstructured":"Pillarisetti, S. et al. Endothelial cell heparanase modulation of lipoprotein lipase activity. J. Biol. Chem. 272, 15753\u2013 15759 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFnm0799793_CR33","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1172\/JCI111603","volume":"74","author":"J Yahalom","year":"1984","unstructured":"Yahalom, J., Eldor, A., Fuks, Z. & Vlodavsky, I. Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase. J. Clin. Invest. 74, 1842\u20131849 (1984).","journal-title":"J. Clin. Invest."},{"key":"BFnm0799793_CR34","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1182\/blood.V75.11.2204.2204","volume":"75","author":"P Bashkin","year":"1990","unstructured":"Bashkin, P., Razin, E., Eldor, A. & Vlodavsky, I. Degranulating mast cells secrete an endoglycosidase which degrades heparan sulfate in subendothelial extracellular matrix. Blood 75, 2204\u2013 2212 (1990).","journal-title":"Blood"},{"key":"BFnm0799793_CR35","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1172\/JCI112104","volume":"76","author":"Y Matzner","year":"1985","unstructured":"Matzner, Y. et al. Degradation of heparan sulfate in the subendothelial basement membrane by a readily released heparanase from human neutrophils. J. Clin. Invest. 76, 1306\u20131313 (1985).","journal-title":"J. Clin. Invest."},{"key":"BFnm0799793_CR36","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/310241a0","volume":"310","author":"Y Naparstek","year":"1984","unstructured":"Naparstek, Y., Cohen, I.R., Fuks, Z. & Vlodavsky, I. Activated T lymphocytes produce a matrix-degrading heparan sulfate endoglycosidase. Nature 310, 241\u2013243 (1984).","journal-title":"Nature"},{"key":"BFnm0799793_CR37","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/ijc.2910450613","volume":"45","author":"T Peretz","year":"1990","unstructured":"Peretz, T. et al. Maintenance on extracellular matrix and expression of heparanase activity by human ovarian carcinoma cells from biopsy specimens. Int. J. Cancer 45, 1054\u20131060 (1990).","journal-title":"Int. J. Cancer"},{"key":"BFnm0799793_CR38","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/0955-0674(93)90040-W","volume":"5","author":"DE Kleiner","year":"1993","unstructured":"Kleiner, D. E. & Stetler-Stevenson, W. G. Structural biochemstry and activation of matrix metalloproteases. Curr. Opin. Cell Biol. 5, 891\u2013897 (1993).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnm0799793_CR39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF00049520","volume":"9","author":"WG Stetler-Stevenson","year":"1990","unstructured":"Stetler-Stevenson, W. G. Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev. 9, 289\u2013303 (1990).","journal-title":"Cancer Metastasis Rev."},{"key":"BFnm0799793_CR40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1152\/physrev.1993.73.1.161","volume":"73","author":"P Mignatti","year":"1993","unstructured":"Mignatti, P. & Rifkin, D. B. Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev. 73, 161\u2013195 (1993).","journal-title":"Physiol. Rev."},{"key":"BFnm0799793_CR41","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/ijc.2910350411","volume":"35","author":"M Bar-Ner","year":"1985","unstructured":"Bar-Ner, M. et al. Sequential degradation of heparan sulfate in the subendothelial extracellular matrix by highly metastatic lymphoma cells. Int. J. Cancer 35, 483\u2013491 (1985).","journal-title":"Int. J. Cancer"},{"key":"BFnm0799793_CR42","unstructured":"Vlodavsky, I. et al. in Tumor Angiogenesis (eds. Lewis, C.E., Bicknell, R &Ferrara, N.) 125\u2013140 (Oxford University Press, Oxford, UK, 1997)."},{"key":"BFnm0799793_CR43","doi-asserted-by":"crossref","unstructured":"Vlodavsky, I., Bar-Shavit, R., Korner, G. & Fuks, Z. in Basement Membranes: Cellular and Molecular Aspects (eds. Rohrbach, D.H. & Timpl, R.) 327\u2013343 (Academic, Orlando, Florida, 1993).","DOI":"10.1016\/B978-0-12-593165-6.50022-X"},{"key":"BFnm0799793_CR44","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/0092-8674(91)90512-W","volume":"64","author":"A Yayon","year":"1991","unstructured":"Yayon, A., Klagsbrun, M., Esko, J.D., Leder, P. & Ornitz, D.M. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64, 841\u2013 848 (1991).","journal-title":"Cell"},{"key":"BFnm0799793_CR45","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1172\/JCI119319","volume":"99","author":"H-Q Miao","year":"1997","unstructured":"Miao, H-Q., Ornitz, D. M., Eingorn, E., Ben-Sasson, S. A. & Vlodavsky I. Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling and angiogenic activity by a synthetic heparin-mimicking polyanionic compound. J. Clin. Invest. 99, 1565\u20131575 (1997).","journal-title":"J. Clin. Invest."},{"key":"BFnm0799793_CR46","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1073\/pnas.84.8.2292","volume":"84","author":"I Vlodavsky","year":"1987","unstructured":"Vlodavsky, I. et al. Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix. Proc. Natl. Acad. Sci. USA 84, 2292\u20132296 (1987).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnm0799793_CR47","doi-asserted-by":"crossref","unstructured":"Vlodavsky, I. & Christofori, G. in Antiangiogenic Agents in Cancer Therapy (ed. Teicher, B.A.) 93\u2013118 (Humana, Totowa, New Jersey, 1998).","DOI":"10.1007\/978-1-59259-453-5_7"},{"key":"BFnm0799793_CR48","first-page":"6075","volume":"50","author":"HD Soule","year":"1990","unstructured":"Soule, H.D. et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res. 50, 6075\u20136086 (1990).","journal-title":"Cancer Res."},{"key":"BFnm0799793_CR49","unstructured":"Vlodavsky, I. in Current protocols in Cell Biology, Vol. I, Suppl. I (eds. Bonifacino, J.S., Dasso, M, Harford, J.B, Lippincott-Schwartz, J & Yamada, K.M.) 10.4.1\u201310.4.14 (John Wiley & Sons, New York, New York, 1999)."},{"key":"BFnm0799793_CR50","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1093\/nar\/25.9.1678","volume":"25","author":"K Savitsky","year":"1997","unstructured":"Savitsky, K. et al. Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-translational regulation of ATM gene expression. Nucleic Acids Res. 25, 1678\u2013 1684 (1997).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm0799_793.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm0799_793","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/10518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nm0799_793.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T23:35:08Z","timestamp":1682033708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm0799_793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["BFnm0799793"],"URL":"https:\/\/doi.org\/10.1038\/10518","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}