{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:10:36Z","timestamp":1764688236619},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1038\/12709","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:32:58Z","timestamp":1027672378000},"page":"104-107","source":"Crossref","is-referenced-by-count":73,"title":["A novel member of the F-box\/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant"],"prefix":"10.1038","volume":"23","author":[{"given":"Arend","family":"Sidow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique S.","family":"Bulotsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne W.","family":"Kerrebrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce W.","family":"Birren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Jaenisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Lander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BFng0999_104_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/jez.1401080304","volume":"108","author":"JW Saunders","year":"1948","unstructured":"Saunders, J.W. The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool. 108, 363\u2013403 (1948).","journal-title":"J. Exp. Zool."},{"key":"BFng0999_104_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/0012-1606(63)90107-6","volume":"7","author":"JW Saunders","year":"1963","unstructured":"Saunders, J.W. & Gasseling, M.T. Trans-filter propagation of apical ectoderm maintenance factor in the chick embryo wing bud. Dev. Biol. 7, 64\u201378 ( 1963).","journal-title":"Dev. Biol."},{"key":"BFng0999_104_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/oxfordjournals.jhered.a109486","volume":"72","author":"CK Chai","year":"1981","unstructured":"Chai, C.K. Dactylaplasia in mice. J. Hered. 72, 234\u2013237 (1981).","journal-title":"J. Hered."},{"key":"BFng0999_104_CR4","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1006\/geno.1995.9981","volume":"29","author":"KR Johnson","year":"1995","unstructured":"Johnson, K.R., Lane, P.W., Ward-Bailey, P. & Davisson M.T. Mapping the mouse Dactylaplasia mutation, Dac, and a gene that controls its expression, mdac. Genomics 29, 457\u2013464 (1995).","journal-title":"Genomics"},{"key":"BFng0999_104_CR5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1006\/dbio.1998.8938","volume":"201","author":"MA Crackower","year":"1998","unstructured":"Crackower, M.A., Motoyama, J. & Tsui, L.C. Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse. Dev. Biol. 201, 78\u201389 (1998).","journal-title":"Dev. Biol."},{"key":"BFng0999_104_CR6","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1093\/hmg\/4.11.2165","volume":"4","author":"ME Nunes","year":"1995","unstructured":"Nunes, M.E. et al. A second autosomal split hand\/split foot locus maps to chromosome 10q24-q25. Hum. Mol. Genet. 4, 2165\u2013 2170 (1995).","journal-title":"Hum. Mol. Genet."},{"key":"BFng0999_104_CR7","doi-asserted-by":"crossref","DOI":"10.56021\/9780801857423","volume-title":"Mendelian Inheritance in Man. Catalogs of Human Genes and Genetic Disorders","author":"VA McKusick","year":"1998","unstructured":"McKusick, V.A. Mendelian Inheritance in Man. Catalogs of Human Genes and Genetic Disorders (Johns Hopkins University Press, Baltimore, 1998)."},{"key":"BFng0999_104_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/S0168-9525(98)01473-5","volume":"14","author":"EE Patton","year":"1998","unstructured":"Patton, E.E., Willems, A.R. & Tyers, M. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet. 14, 236\u201343 (1998).","journal-title":"Trends Genet."},{"key":"BFng0999_104_CR9","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/sj.onc.1202653","volume":"18","author":"E Latres","year":"1999","unstructured":"Latres, E., Chiaur, D.S. & Pagano, M. The human F box protein \u03b2-TrCP associates with the Cul1\/Skp1 complex and regulates the stability of \u03b2-catenin. Oncogene 18, 849\u2013854 ( 1999).","journal-title":"Oncogene"},{"key":"BFng0999_104_CR10","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1101\/gad.13.3.284","volume":"13","author":"E Spencer","year":"1999","unstructured":"Spencer, E., Jiang, J. & Chen, Z.J. Signal-induced ubiquitination of I\u03baB\u03b1 by the F-box protein Slimb\/\u03b2-TrCP. Genes Dev. 13, 284\u2013294 (1999).","journal-title":"Genes Dev."},{"key":"BFng0999_104_CR11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1101\/gad.13.3.270","volume":"13","author":"JT Winston","year":"1999","unstructured":"Winston, J.T. et al. The SCF\u03b2-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in I\u03baB\u03b1 and \u03b2-catenin and stimulates I\u03baB\u03b1 ubiquitination in vitro. Genes Dev. 13, 270\u2013283 ( 1999).","journal-title":"Genes Dev."},{"key":"BFng0999_104_CR12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/25159","volume":"396","author":"A Yaron","year":"1998","unstructured":"Yaron, A. et al. Identification of the receptor component of the I\u03baB\u03b1-ubiquitin ligase. Nature 396, 590\u2013 594 (1998).","journal-title":"Nature"},{"key":"BFng0999_104_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1006\/geno.1994.1506","volume":"23","author":"SA Keller","year":"1994","unstructured":"Keller, S.A. et al. Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics 23, 309\u2013320 ( 1994).","journal-title":"Genomics"},{"key":"BFng0999_104_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0959-437X(98)80092-0","volume":"8","author":"HH Kazazian Jr","year":"1998","unstructured":"Kazazian, H.H. Jr Mobile elements and disease. Curr. Opin. Genet. Dev. 8, 343\u2013350 ( 1998).","journal-title":"Curr. Opin. Genet. Dev."},{"key":"BFng0999_104_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1101\/gr.4.2.109","volume":"4","author":"W Ji","year":"1994","unstructured":"Ji, W., Zhang, X.Y., Warshamana, G.S., Qu, G.Z. & Ehrlich, M. Effect of internal direct and inverted Alu repeat sequences on PCR. PCR Methods Appl. 4, 109\u2013116 (1994).","journal-title":"PCR Methods Appl."},{"key":"BFng0999_104_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0092-8674(00)80098-7","volume":"86","author":"C Bai","year":"1996","unstructured":"Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86 , 263\u2013274 (1996).","journal-title":"Cell"},{"key":"BFng0999_104_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1046\/j.1365-2443.1998.00225.x","volume":"3","author":"K Kominami","year":"1998","unstructured":"Kominami, K., Ochotorena, I. & Toda, T. Two F-box\/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 3, 721\u2013 735 (1998).","journal-title":"Genes Cells"},{"key":"BFng0999_104_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0092-8674(00)80403-1","volume":"91","author":"D Skowyra","year":"1997","unstructured":"Skowyra, D., Craig, K.L., Tyers, M., Elledge S.J. & Harper, J.W. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209\u2013219 (1997).","journal-title":"Cell"},{"key":"BFng0999_104_CR19","unstructured":"Wolf, D.A., McKeon, F. & Jackson, P.K. F-box\/WD repeat proteins Pop1p and Pop2p form heterooligomeric complexes to bind and direct the proteolytic destruction of Cdc18p. Curr. Biol. (in press)."},{"key":"BFng0999_104_CR20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1128\/MCB.19.1.635","volume":"19","author":"CH Yam","year":"1999","unstructured":"Yam, C.H., Ng, R.W., Siu, W.Y., Lau, A.W. & Poon, R.Y. Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2. Mol. Cell. Biol. 19, 635\u2013645 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BFng0999_104_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/35154","volume":"391","author":"J Jiang","year":"1998","unstructured":"Jiang, J. & Struhl, G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box\/WD40-repeat protein Slimb. Nature 391, 493\u2013496 ( 1998).","journal-title":"Nature"},{"key":"BFng0999_104_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/0092-8674(95)90220-1","volume":"83","author":"MA Wall","year":"1995","unstructured":"Wall, M.A. et al. The structure of the G protein heterotrimer Gi \u03b1 1 \u03b2 1 \u03b3 2. Cell 83, 1047\u2013 1058 (1995).","journal-title":"Cell"},{"key":"BFng0999_104_CR23","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1242\/dev.124.22.4547","volume":"124","author":"M Altabef","year":"1997","unstructured":"Altabef, M., Clarke, J.D. & Tickle, C. Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development 124, 4547\u20134556 (1997).","journal-title":"Development"},{"key":"BFng0999_104_CR24","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/dev.125.6.1137","volume":"125","author":"CA Loomis","year":"1998","unstructured":"Loomis, C.A., Kimmel, R.A., Tong, C.X., Michaud, J. & Joyner, A.L. Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs. Development 125, 1137\u20131148 (1998).","journal-title":"Development"},{"key":"BFng0999_104_CR25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.124.8.1453","volume":"124","author":"JL Michaud","year":"1997","unstructured":"Michaud, J.L., Lapointe, F. & Le Douarin, N.M. The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure. Development 124, 1453\u2013 1463 (1997).","journal-title":"Development"},{"key":"BFng0999_104_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0925-4773(91)90067-G","volume":"36","author":"P Dolle","year":"1991","unstructured":"Dolle, P., Izpisua-Belmonte, J.C., Boncinelli, E. & Duboule, D. The Hox-4.8 gene is localized at the 5\u2032 extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development. Mech. Dev. 36, 3\u201313 (1991).","journal-title":"Mech. Dev."},{"key":"BFng0999_104_CR27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1242\/dev.109.4.833","volume":"109","author":"KM Lyons","year":"1990","unstructured":"Lyons, K.M., Pelton, R.W. & Hogan, B.L. Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). Development 109, 833\u2013 844 (1990).","journal-title":"Development"},{"key":"BFng0999_104_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0076-6879(93)25025-W","volume":"225","author":"DG Wilkinson","year":"1993","unstructured":"Wilkinson, D.G. & Nieto, M.A. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225, 361\u2013373 (1993).","journal-title":"Methods Enzymol."},{"key":"BFng0999_104_CR29","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/39587","volume":"389","author":"A Sidow","year":"1997","unstructured":"Sidow, A. et al. Serrate2 is disrupted in the mouse limb-development mutant syndactylism. Nature 389, 722\u2013 725 (1997).","journal-title":"Nature"},{"key":"BFng0999_104_CR30","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul, S.F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389\u20133402 (1997).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng0999_104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0999_104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng0999_104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T22:41:09Z","timestamp":1682030469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng0999_104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["BFng0999_104"],"URL":"https:\/\/doi.org\/10.1038\/12709","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}