{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:52:41Z","timestamp":1791021161158,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1038\/13802","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:34:58Z","timestamp":1027672498000},"page":"176-184","source":"Crossref","is-referenced-by-count":423,"title":["Genomic instability in Gadd45a-deficient mice"],"prefix":"10.1038","volume":"23","author":[{"given":"M. Christine","family":"Hollander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Saeed","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry V.","family":"Bulavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Augeri-Henmueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Shehee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Tolosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Ashwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Fern\u00e1ndez-Salguero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Xia","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Albert J.","family":"Fornace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1099_176_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0092-8674(92)90593-2","volume":"71","author":"MB Kastan","year":"1992","unstructured":"Kastan, M.B.  et al. A mammalian cell cycle checkpoint utilizing p53 and GADD45  is defective in ataxia telangiectasia. Cell 71 , 587\u2013597 (1992).","journal-title":"Cell"},{"key":"BFng1099_176_CR2","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1128\/MCB.18.5.2768","volume":"18","author":"Q Zhan","year":"1998","unstructured":"Zhan, Q., Chen, I.T., Antinore, M.J. & Fornace, A.J. Jr Tumor suppressor p53 can participate in transcriptional induction of the  GADD45 promoter in the absence of direct DNA binding. Mol. Cell. Biol. 18, 2768\u20132778 (1998).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1099_176_CR3","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1038\/sj.onc.1202576","volume":"17","author":"SA Amundson","year":"1998","unstructured":"Amundson, S.A., Myers, T.G. & Fornace, A.J. Jr Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene  17, 3287\u20133300 ( 1998).","journal-title":"Oncogene"},{"key":"BFng1099_176_CR4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0092-8674(00)80769-2","volume":"97","author":"DP Harkin","year":"1999","unstructured":"Harkin, D.P.  et al. Induction of GADD45 and JNK\/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell  97, 575\u2013586 (1999).","journal-title":"Cell"},{"key":"BFng1099_176_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/356215a0","volume":"356","author":"LA Donehower","year":"1992","unstructured":"Donehower, L.A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215\u2013221 (1992).","journal-title":"Nature"},{"key":"BFng1099_176_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/ng0695-175","volume":"10","author":"VP Sah","year":"1995","unstructured":"Sah, V.P. et al. A subset of p53-deficient embryos exhibit exencephaly.  Nature Genet. 10, 175\u2013180 (1995).","journal-title":"Nature Genet."},{"key":"BFng1099_176_CR7","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1101\/gad.10.9.1054","volume":"10","author":"LJ Ko","year":"1996","unstructured":"Ko, L.J. & Prives, C. p53: puzzle and paradigm.  Genes Dev. 10, 1054\u20131072 (1996).","journal-title":"Genes Dev."},{"key":"BFng1099_176_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0092-8674(95)90039-X","volume":"82","author":"C Deng","year":"1995","unstructured":"Deng, C., Zhang, P., Harper, J.W., Elledge, S.J. & Leder, P. Mice lacking p21CIP1\/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell  82, 675\u2013684 (1995).","journal-title":"Cell"},{"key":"BFng1099_176_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/377552a0","volume":"377","author":"J Brugarolas","year":"1995","unstructured":"Brugarolas, J.  et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552\u2013557 (1995).","journal-title":"Nature"},{"key":"BFng1099_176_CR10","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1126\/science.7973727","volume":"266","author":"ML Smith","year":"1994","unstructured":"Smith, M.L.  et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266, 1376\u2013 1380 (1994).","journal-title":"Science"},{"key":"BFng1099_176_CR11","first-page":"1675","volume":"11","author":"JM Kearsey","year":"1995","unstructured":"Kearsey, J.M., Coates, P.J., Prescott, A.R., Warbrick, E. & Hall, P.A. Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1. Oncogene  11, 1675\u20131683 (1995).","journal-title":"Oncogene"},{"key":"BFng1099_176_CR12","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0092-8674(00)81619-0","volume":"95","author":"M Takekawa","year":"1998","unstructured":"Takekawa, M. & Saito, H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1\/MEKK4 MAPKKK.  Cell 95, 521\u2013530 ( 1998).","journal-title":"Cell"},{"key":"BFng1099_176_CR13","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1038\/sj.onc.1202667","volume":"18","author":"Q Zhan","year":"1999","unstructured":"Zhan, Q. et al. Association with Cdc2 and inhibition of Cdc2\/cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene  18, 2892\u20132900 (1999).","journal-title":"Oncogene"},{"key":"BFng1099_176_CR14","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1128\/MCB.19.3.1673","volume":"19","author":"F Carrier","year":"1999","unstructured":"Carrier, F.  et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol. Cell. Biol. 19, 1673\u20131685 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BFng1099_176_CR15","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1073\/pnas.96.7.3706","volume":"96","author":"XW Wang","year":"1999","unstructured":"Wang, X.W.  et al. Gadd45 induction of a G2-M cell cycle checkpoint. Proc. Natl Acad. Sci. USA 96, 3706\u2013 3711 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1099_176_CR16","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/0092-8674(92)90243-6","volume":"70","author":"LR Livingstone","year":"1992","unstructured":"Livingstone, L.R.  et al. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70, 923\u2013935 (1992).","journal-title":"Cell"},{"key":"BFng1099_176_CR17","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0092-8674(00)80452-3","volume":"91","author":"T Kamijo","year":"1997","unstructured":"Kamijo, T.  et al. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell  91, 649\u2013659 (1997).","journal-title":"Cell"},{"key":"BFng1099_176_CR18","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S0955-0674(99)80015-5","volume":"11","author":"W Zimmerman","year":"1999","unstructured":"Zimmerman, W., Sparks, C.A. & Doxsey, S.J. Amorphous no longer: the centrosome comes into focus. Curr. Opin. Cell Biol. 11, 122\u2013 128 (1999).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFng1099_176_CR19","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1073\/pnas.94.7.3022","volume":"94","author":"SM Pockwinse","year":"1997","unstructured":"Pockwinse, S.M.  et al. Cell cycle independent interaction of CDC2 with the centrosome, which is associated with the nuclear matrix-intermediate filament scaffold. Proc. Natl Acad. Sci. USA 94, 3022\u2013 3027 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1099_176_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/24179","volume":"396","author":"ML Fero","year":"1998","unstructured":"Fero, M.L., Randel, E., Gurley, K.E., Roberts, J.M. & Kemp, C.J. The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature 396, 177\u2013 180 (1998).","journal-title":"Nature"},{"key":"BFng1099_176_CR21","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ng0994-66","volume":"8","author":"CJ Kemp","year":"1994","unstructured":"Kemp, C.J., Wheldon, T. & Balmain, A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nature Genet. 8, 66\u2013 69 (1994).","journal-title":"Nature Genet."},{"key":"BFng1099_176_CR22","first-page":"3883","volume":"55","author":"SD Bouffler","year":"1995","unstructured":"Bouffler, S.D., Kemp, C.J., Balmain, A. & Cox, R. Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.  Cancer Res. 55, 3883\u20133889 (1995).","journal-title":"Cancer Res."},{"key":"BFng1099_176_CR23","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1126\/science.282.5393.1497","volume":"282","author":"F Bunz","year":"1998","unstructured":"Bunz, F. et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497\u20131501 (1998).","journal-title":"Science"},{"key":"BFng1099_176_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1126\/science.270.5233.96","volume":"270","author":"CM Knudson","year":"1995","unstructured":"Knudson, C.M., Tung, K.S., Tourtellotte, W.G., Brown, G.A. & Korsmeyer, S.J. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270, 96\u201399 (1995).","journal-title":"Science"},{"key":"BFng1099_176_CR25","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","volume":"88","author":"M Serrano","year":"1997","unstructured":"Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D. & Lowe, S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.  Cell 88, 593\u2013602 ( 1997).","journal-title":"Cell"},{"key":"BFng1099_176_CR26","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s004120050256","volume":"106","author":"MJ Hendzel","year":"1997","unstructured":"Hendzel, M.J.  et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma  106, 348\u2013360 ( 1997).","journal-title":"Chromosoma"},{"key":"BFng1099_176_CR27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","volume":"19","author":"H Hennings","year":"1980","unstructured":"Hennings, H.  et al. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19, 245 \u2013254 (1980).","journal-title":"Cell"},{"key":"BFng1099_176_CR28","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/362847a0","volume":"362","author":"SW Lowe","year":"1993","unstructured":"Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847\u2013849 (1993).","journal-title":"Nature"},{"key":"BFng1099_176_CR29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000131490","volume":"27","author":"WA Nelson-Rees","year":"1980","unstructured":"Nelson-Rees, W.A., Hunter, L., Darlington, G.J. & O'Brien, S.J. Characteristics of HeLa strains: permanent vs. variable features.  Cytogenet. Cell Genet. 27, 216\u2013231 (1980).","journal-title":"Cytogenet. Cell Genet."},{"key":"BFng1099_176_CR30","unstructured":"Wang, X. Gorospe, M. & Holbrook, N.J. gadd45 is not required for activation of c-jun N-terminal kinase or p38 during acute stress. J. Biol. Chem. (in press)."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1099_176.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1099_176","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1099_176.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:32:18Z","timestamp":1638390738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1099_176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["BFng1099_176"],"URL":"https:\/\/doi.org\/10.1038\/13802","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}