{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T09:04:15Z","timestamp":1765098255970},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Med"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1038\/15191","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:43:33Z","timestamp":1027673013000},"page":"1239-1241","source":"Crossref","is-referenced-by-count":102,"title":["Signaling mismatch repair in cancer"],"prefix":"10.1038","volume":"5","author":[{"given":"Richard","family":"Fishel","sequence":"first","affiliation":[]}],"member":"297","reference":[{"key":"BFnm1199_1239_CR1","first-page":"1","volume":"31","author":"T Bocker","year":"1999","unstructured":"Bocker, T., Ruschoff, J. & Fishel, R. Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects. Biochim. Biophys. Acta 31, 1\u201310 (1999).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnm1199_1239_CR2","first-page":"4749","volume":"57","author":"W Dietmaier","year":"1997","unstructured":"Dietmaier, W. et al. Diagnostic microsatellite instability\u2014definition and correlation with mismatch repair protein expression. Cancer Res. 57, 4749\u20134756 (1997).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/15544","volume":"23","author":"de Wind","year":"1999","unstructured":"de Wind, et al. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch repair protein functions. Nature Gen. 23, 359\u2013362 (1999).","journal-title":"Nature Gen."},{"key":"BFnm1199_1239_CR4","doi-asserted-by":"crossref","unstructured":"Wijnen, J., et al. Familial endometrial cancer in female carriers of MSH6 germline mutations. Nature Gen. 23, 142\u2013144.","DOI":"10.1038\/13773"},{"key":"BFnm1199_1239_CR5","first-page":"5068","volume":"59","author":"Kolodner","year":"1999","unstructured":"Kolodner, et al. Germline MSH6 mutation in colorectal cancer families. Cancer Res. 59, 5068\u20135074 (1999).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR6","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0092-8674(00)80490-0","volume":"91","author":"S Gradia","year":"1997","unstructured":"Gradia, S., Acharya, S. & Fishel, R. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch. Cell. 91, 995\u20131005 (1997).","journal-title":"Cell."},{"key":"BFnm1199_1239_CR7","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1101\/gad.12.14.2096","volume":"12","author":"R Fishel","year":"1998","unstructured":"Fishel, R. Mismatch repair, molecular switches, and signal transduction. Genes and Dev. 12, 2096\u20132101 (1998).","journal-title":"Genes and Dev."},{"key":"BFnm1199_1239_CR8","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1097-2765(00)80316-0","volume":"3","author":"S Gradia","year":"1999","unstructured":"Gradia, S. et al. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA. Mol. Cell 3, 255\u2013261 (1999).","journal-title":"Mol. Cell"},{"key":"BFnm1199_1239_CR9","first-page":"3075","volume":"51","author":"LA Loeb","year":"1991","unstructured":"Loeb, L.A. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 51, 3075\u20133079 (1991).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR10","first-page":"3087","volume":"56","author":"S Aebi","year":"1996","unstructured":"Aebi, S. et al. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res. 56, 3087\u20133090 (1996).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR11","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/nar\/20.12.2933","volume":"20","author":"P Karran","year":"1992","unstructured":"Karran, P. & Bignami, M. Self-distruction and tolerance in resistance of mammalian cells to alkylation damage. Nucl. Acids Res. 20, 2933\u20132940 (1992).","journal-title":"Nucl. Acids Res."},{"key":"BFnm1199_1239_CR12","first-page":"767","volume":"58","author":"TW Davis","year":"1998","unstructured":"Davis, T.W. et al. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 58, 767\u2013778 (1998).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0092-8674(00)80433-X","volume":"91","author":"W Edelmann","year":"1997","unstructured":"Edelmann, W. et al. Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell 91, 467\u2013477 (1997).","journal-title":"Cell"},{"key":"BFnm1199_1239_CR14","doi-asserted-by":"publisher","first-page":"11301","DOI":"10.1073\/pnas.95.19.11301","volume":"95","author":"J Ruschoff","year":"1998","unstructured":"Ruschoff, J. et al. Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc. Natl. Acad. of Sci. USA 95, 11301\u201311306 (1998).","journal-title":"Proc. Natl. Acad. of Sci. USA"},{"key":"BFnm1199_1239_CR15","first-page":"3021","volume":"59","author":"H Zhang","year":"1999","unstructured":"Zhang, H. et al. Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res. 59, 3021\u20133027 (1999).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR16","first-page":"3920","volume":"57","author":"Y Akiyama","year":"1997","unstructured":"Akiyama, Y. et al. Germ-line mutation of the hMSH6\/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 57, 3920\u20133923 (1997).","journal-title":"Cancer Res."},{"key":"BFnm1199_1239_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/ng1197-271","volume":"17","author":"M Miyaki","year":"1997","unstructured":"Miyaki, M. et al. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nature Gen. 17, 271\u2013272 (1997).","journal-title":"Nature Gen."}],"container-title":["Nature Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nm1199_1239","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1199_1239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nm1199_1239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:02:37Z","timestamp":1638399757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nm1199_1239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["BFnm1199_1239"],"URL":"https:\/\/doi.org\/10.1038\/15191","relation":{},"ISSN":["1078-8956","1546-170X"],"issn-type":[{"value":"1078-8956","type":"print"},{"value":"1546-170X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}