{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:19:20Z","timestamp":1793067560345,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6717","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1999,1]]},"DOI":"10.1038\/16852","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:39:18Z","timestamp":1027672758000},"page":"315-323","source":"Crossref","is-referenced-by-count":2819,"title":["OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis"],"prefix":"10.1038","volume":"397","author":[{"given":"Young-Yun","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Sarosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Lin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Timms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Capparelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Morony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Oliveira-dos-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth","family":"Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Itie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Khoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wakeham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Lacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak W.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M.","family":"Penninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF16852_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1530\/eje.0.1340143","volume":"134","author":"R Felix","year":"1996","unstructured":"Felix, R., Hofstetter, W. & Cecchini, M. G. Recent developments in the understanding of the pathophysiology of osteopetrosis. Eur. J. Endocrinol. 134, 143\u2013156 (1996).","journal-title":"Eur. J. Endocrinol."},{"key":"BF16852_CR2","first-page":"308","volume":"17","author":"GD Roodman","year":"1996","unstructured":"Roodman, G. D. Advances in bone biology: the osteoclast. Endocr. Hev. 17, 308\u2013332 (1996).","journal-title":"Endocr. Hev."},{"key":"BF16852_CR3","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1056\/NEJM199502023320506","volume":"332","author":"SC Manolagas","year":"1995","unstructured":"Manolagas, S. C. & Jilka, R. L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. New Engl. J. Med. 332, 305\u2013311 (1995).","journal-title":"New Engl. J. Med."},{"key":"BF16852_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/1357-4310(96)81801-6","volume":"2","author":"SN Popoff","year":"1996","unstructured":"Popoff, S. N. & Schneider, G. B. Animal models of osteopetrosis: the impact of recent molecular developments on novel strategies for therapeutic intervention. Mol. Med. Today 2, 349\u2013358 (1996).","journal-title":"Mol. Med. Today"},{"key":"BF16852_CR5","first-page":"399","volume":"63","author":"SI Teitelbaum","year":"1996","unstructured":"Teitelbaum, S. I. The osteoclast and osteoporosis. Mt Sinai J. Med. 63, 399\u2013402 (1996).","journal-title":"Mt Sinai J. Med."},{"key":"BF16852_CR6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0092-8674(00)80193-2","volume":"89","author":"AH Reddi","year":"1997","unstructured":"Reddi, A. H. Bone morphogenesis and modeling: soluble signals sculpt osteosomes in the solid state. Cell 89, 159\u2013161 (1997).","journal-title":"Cell"},{"key":"BF16852_CR7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1126\/science.276.5310.219","volume":"276","author":"K Mostov","year":"1997","unstructured":"Mostov, K. & Werb, Z. Journey across the osteoclast. Science 276, 219\u2013220 (1997).","journal-title":"Science"},{"key":"BF16852_CR8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0889-8529(05)70248-6","volume":"26","author":"CJ Rosen","year":"1997","unstructured":"Rosen, CJ. & Kessenich, C. R. The pathophysiology and treatment of postmenopausal osteoporosis. An evidence-based approach to estrogen replacement therapy. Endocr. Metab. Clin. North Am. 26, 295\u2013311 (1997).","journal-title":"Endocr. Metab. Clin. North Am."},{"key":"BF16852_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/8756-3282(95)00194-I","volume":"17 (suppl.)","author":"JA Kanis","year":"1995","unstructured":"Kanis, J. A. Bone and cancer: pathophysiology and treatment of metastases. Bone 17 (suppl.), 101\u2013105 (1995).","journal-title":"Bone"},{"key":"BF16852_CR10","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1136\/ard.44.7.438","volume":"44","author":"M Seitz","year":"1985","unstructured":"Seitz, M. & Hunstein, W. Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus. Annu. Rheum. Dis. 44, 438\u2013445 (1985).","journal-title":"Annu. Rheum. Dis."},{"key":"BF16852_CR11","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/345442a0","volume":"345","author":"H Yoshida","year":"1990","unstructured":"Yoshida, H. et al. The murine mutation osteopetrosis in in the coding region of the macrophage colony stimulating factor gene. Nature 345, 442\u2013444 (1990).","journal-title":"Nature"},{"key":"BF16852_CR12","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1073\/pnas.87.12.4828","volume":"87","author":"W Wiktor-Jedrzejczak","year":"1990","unstructured":"Wiktor-Jedrzejczak, W. et al. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op\/op) mouse. Proc. Natl Acad. Sci. USA 87, 4828\u20134832 (1990).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF16852_CR13","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/S0092-8674(00)80290-1","volume":"89","author":"E Lagasse","year":"1997","unstructured":"Lagasse, E. & Weissman, I. L. Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op\/op mice. Cell 89, 1021\u20131031 (1997).","journal-title":"Cell"},{"key":"BF16852_CR14","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1084\/jem.177.1.237","volume":"177","author":"SK Begg","year":"1993","unstructured":"Begg, S. K. et al. Delayed hematopoietic development in osteopetrotic (op\/op) mice. J. Exp. Med. 177, 237\u2013242 (1993).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey, D. L. et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165\u2013176 (1998).","journal-title":"Cell"},{"key":"BF16852_CR16","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"H Yasuda","year":"1998","unstructured":"Yasuda, H. et al. Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL. Proc. Natl Acad. Sci. USA 95, 3597\u20133602 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF16852_CR17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"DM Anderson","year":"1997","unstructured":"Anderson, D. M. et al. Ahomologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175\u2013179 (1997).","journal-title":"Nature"},{"key":"BF16852_CR18","doi-asserted-by":"publisher","first-page":"25190","DOI":"10.1074\/jbc.272.40.25190","volume":"272","author":"BR Wong","year":"1997","unstructured":"Wong, B. R. et al. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272, 25190\u201325194 (1997).","journal-title":"J. Biol. Chem."},{"key":"BF16852_CR19","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1084\/jem.186.12.2075","volume":"186","author":"BR Wong","year":"1997","unstructured":"Wong, B. R. et al. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186, 2075\u20132080 (1997).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR20","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1126\/science.7939685","volume":"266","author":"AE Grigoriadis","year":"1994","unstructured":"Grigoriadis, A. E. et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443\u2013448 (1994).","journal-title":"Science"},{"key":"BF16852_CR21","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/0092-8674(91)90499-O","volume":"64","author":"P Soriano","year":"1991","unstructured":"Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693\u2013702 (1991).","journal-title":"Cell"},{"key":"BF16852_CR22","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/nm1197-1285","volume":"3","author":"V Iotsova","year":"1997","unstructured":"Iotsova, V. et al. Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nature Med. 3, 1285\u20131289 (1997).","journal-title":"Nature Med."},{"key":"BF16852_CR23","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","volume":"11","author":"G Franzoso","year":"1997","unstructured":"Franzoso, G. et al. Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev. 11, 3482\u20133496 (1997).","journal-title":"Genes Dev."},{"key":"BF16852_CR24","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1182\/blood.V74.4.1295.1295","volume":"74","author":"N Kurihara","year":"1989","unstructured":"Kurihara, N. et al. Generation of osteoclasts from isolated heatopoietic progenitor cells. Blood 74, 1295\u20131302 (1989).","journal-title":"Blood"},{"key":"BF16852_CR25","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1210\/endo-126-5-2733","volume":"126","author":"N Kurihara","year":"1990","unstructured":"Kurihara, N., Chenu, C., Miller, M., Civin, C. & Roodman, G. D. Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures. Endocrinology 126, 2733\u20132741 (1990).","journal-title":"Endocrinology"},{"key":"BF16852_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.immunol.14.1.73","volume":"14","author":"G Anderson","year":"1996","unstructured":"Anderson, G., Moore, N. C., Owen, J. J. & Jenkinson, E. J. Cellular interactions in thymocyte development. Annu. Rev. Immunol. 14, 73\u201399 (1996).","journal-title":"Annu. Rev. Immunol."},{"key":"BF16852_CR27","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev.immunol.15.1.433","volume":"15","author":"H von Boehmer","year":"1997","unstructured":"von Boehmer, H. & Fehling, H. J. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15, 433\u2013452 (1997).","journal-title":"Annu. Rev. Immunol."},{"key":"BF16852_CR28","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood.V88.10.4029.bloodjournal88104029","volume":"88","author":"KS Akagawa","year":"1996","unstructured":"Akagawa, K. S. et al. Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood 88, 4029\u20134039 (1996).","journal-title":"Blood"},{"key":"BF16852_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1084\/jem.149.1.1","volume":"149","author":"RM Steinman","year":"1979","unstructured":"Steinman, R. M., Kaplan, G., Witmer, M. D. & Cohn, Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp. Med. 149, 1\u201316 (1979).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR30","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1084\/jem.176.6.1693","volume":"176","author":"K Inaba","year":"1992","unstructured":"Inaba, K. et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693\u20131702 (1992).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR31","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1084\/jem.187.11.1849","volume":"187","author":"K Saoulli","year":"1998","unstructured":"Saoulli, K. et al. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J. Exp. med. 187, 1849\u20131862 (1998).","journal-title":"J. Exp. med."},{"key":"BF16852_CR32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4049\/jimmunol.158.2.551","volume":"158","author":"MA DeBenedette","year":"1997","unstructured":"DeBenedette, M. A., Shahinian, A., Mak, T. W. & Watts, T. H. Costimulation of CD28\u2212 T lymphocytes by 4-1BB ligand. J. Immunol. 158, 551\u2013559 (1997).","journal-title":"J. Immunol."},{"key":"BF16852_CR33","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.8171322","volume":"264","author":"P De Togni","year":"1994","unstructured":"De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703\u2013707 (1994).","journal-title":"Science"},{"key":"BF16852_CR34","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1074-7613(00)80292-7","volume":"6","author":"PA Koni","year":"1997","unstructured":"Koni, P. A. et al. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 6, 491\u2013500 (1997).","journal-title":"Immunity"},{"key":"BF16852_CR35","doi-asserted-by":"publisher","first-page":"9302","DOI":"10.1073\/pnas.94.17.9302","volume":"94","author":"MB Alimzhanov","year":"1997","unstructured":"Alimzhanov, M. B. et al. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc. Natl Acad. Sci. USA 94, 9302\u20139307 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF16852_CR36","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1126\/science.271.5253.1289","volume":"271","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto, M. et al. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271, 1289\u20131291 (1996).","journal-title":"Science"},{"key":"BF16852_CR37","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","volume":"184","author":"M Pasparakis","year":"1996","unstructured":"Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397\u20131411 (1996).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1074-7613(00)80588-9","volume":"9","author":"A Futterer","year":"1998","unstructured":"Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M. H. & Pfeffer, K. The lymphotoxin \u03b2 receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59\u201370 (1998).","journal-title":"Immunity"},{"key":"BF16852_CR39","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(00)80589-0","volume":"9","author":"PD Rennert","year":"1998","unstructured":"Rennert, P. D., James, D., Mackey, F., Browning, J. L. & Hochman, P. S. Lymph node genesis is induced by signaling through the lymphotoxin \u03b2 receptor. Immunity 9, 71\u201379 (1998).","journal-title":"Immunity"},{"key":"BF16852_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/aja.1001420103","volume":"142","author":"RP Bailey","year":"1975","unstructured":"Bailey, R. P. & Weiss, L. Ontogeny of human fetal lymph nodes. Am. J. Anat. 142, 15\u201327 (1975).","journal-title":"Am. J. Anat."},{"key":"BF16852_CR41","doi-asserted-by":"publisher","first-page":"9797","DOI":"10.1073\/pnas.94.18.9797","volume":"94","author":"AM Cheng","year":"1997","unstructured":"Cheng, A. M. et al. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc. Natl Acad. Sci. USA 94, 9797\u20139801 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF16852_CR42","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1126\/science.281.5375.416","volume":"281","author":"JL Clements","year":"1998","unstructured":"Clements, J. L. et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281, 416\u2013419 (1998).","journal-title":"Science"},{"key":"BF16852_CR43","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/375795a0","volume":"375","author":"HJ Fehling","year":"1995","unstructured":"Fehling, H. J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 375, 795\u2013798 (1995).","journal-title":"Nature"},{"key":"BF16852_CR44","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1126\/science.280.5365.905","volume":"280","author":"BA Irving","year":"1998","unstructured":"Irving, B. A., Alt, F. W. & Killeen, N. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science 280, 905\u2013908 (1998).","journal-title":"Science"},{"key":"BF16852_CR45","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S1074-7613(00)80367-2","volume":"7","author":"M Turner","year":"1997","unstructured":"Turner, M. et al. Arequirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 7, 451\u2013460 (1997).","journal-title":"Immunity"},{"key":"BF16852_CR46","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1084\/jem.180.5.1955","volume":"180","author":"JJ Peschon","year":"1994","unstructured":"Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955\u20131960 (1994).","journal-title":"J. Exp. Med."},{"key":"BF16852_CR47","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/S0092-8674(00)80289-5","volume":"89","author":"E Maraskovsky","year":"1997","unstructured":"Maraskovsky, E. et al. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1\u2212\/\u2212 mice. Cell 89, 1011\u20131019 (1997).","journal-title":"Cell"},{"key":"BF16852_CR48","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/0092-8674(93)80069-Q","volume":"75","author":"P Mombaerts","year":"1993","unstructured":"Mombaerts, P. et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75, 274\u2013282 (1993).","journal-title":"Cell"},{"key":"BF16852_CR49","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","author":"WS Simonet","year":"1997","unstructured":"Simonet, W. S. et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89, 309\u2013319 (1997).","journal-title":"Cell"},{"key":"BF16852_CR50","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1210\/endo-128-4-1792","volume":"128","author":"N Takahashi","year":"1991","unstructured":"Takahashi, N. et al. Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells. Endocrinology 128, 1792\u20131796 (1991).","journal-title":"Endocrinology"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/16852.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/16852","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/16852.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T23:19:48Z","timestamp":1682032788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/16852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":50,"journal-issue":{"issue":"6717","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["BF16852"],"URL":"https:\/\/doi.org\/10.1038\/16852","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}