{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:40:59Z","timestamp":1694626859240},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4768","license":[{"start":{"date-parts":[[1961,3,1]],"date-time":"1961-03-01T00:00:00Z","timestamp":-278899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1961,3]]},"DOI":"10.1038\/189937a0","type":"journal-article","created":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T21:24:51Z","timestamp":1152048291000},"page":"937-939","source":"Crossref","is-referenced-by-count":10,"title":["Toxicity and Anti-leuk\u00e6mic Effectiveness, in Mice, of 4-Amino-4-deoxy-N10-methyl-5,6,7,8-tetrahydropteroylglutamic Acid (Tetrahydroamethopterin)"],"prefix":"10.1038","volume":"189","author":[{"given":"J. A. R.","family":"MEAD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"VENDITTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"SCHRECKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"GOLDIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. L.","family":"KISLIUK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF189937a0_CR1","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/188584a0","volume":"188","author":"RL Kisliuk","year":"1960","unstructured":"Kisliuk, R. L., Nature, 188, 584 (1960).","journal-title":"Nature"},{"key":"BF189937a0_CR2","first-page":"495","volume":"21","author":"A Goldin","year":"1958","unstructured":"Goldin, A., Venditti, J. M., Humphreys, S. R., and Mantel, N., J. Nat. Cancer Inst., 21, 495 (1958).","journal-title":"J. Nat. Cancer Inst."},{"key":"BF189937a0_CR3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0021-9258(18)70760-6","volume":"227","author":"RL Kisliuk","year":"1957","unstructured":"Kisliuk, R. L., J. Biol. Chem., 227, 805 (1957).","journal-title":"J. Biol. Chem."},{"key":"BF189937a0_CR4","first-page":"633","volume":"23","author":"SR Humphreys","year":"1959","unstructured":"Humphreys, S. R., and Goldin, A., J. Nat. Cancer Inst., 23, 633 (1959).","journal-title":"J. Nat. Cancer Inst."},{"key":"BF189937a0_CR5","first-page":"987","volume":"12","author":"A Goldin","year":"1952","unstructured":"Goldin, A., Greenspan, E. M., Venditti, J. M., and Schoenbach, E. B., J. Nat. Cancer Inst., 12, 987 (1952).","journal-title":"J. Nat. Cancer Inst."},{"key":"BF189937a0_CR6","first-page":"876","volume":"20","author":"AW Schrecker","year":"1960","unstructured":"Schrecker, A. W., Mead, J. A. R., Lynch, M. R., and Goldin, A., Cancer Res., 20, 876 (1960).","journal-title":"Cancer Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/189937a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/189937a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/189937a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:29:47Z","timestamp":1638401387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/189937a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1961,3]]},"references-count":6,"journal-issue":{"issue":"4768","published-print":{"date-parts":[[1961,3]]}},"alternative-id":["BF189937a0"],"URL":"https:\/\/doi.org\/10.1038\/189937a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1961,3]]}}}