{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:57:05Z","timestamp":1778551025714,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6729","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1038\/19546","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:39:24Z","timestamp":1027672764000},"page":"718-723","source":"Crossref","is-referenced-by-count":959,"title":["MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions"],"prefix":"10.1038","volume":"398","author":[{"given":"Robert E.","family":"Gerszten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo A.","family":"Garcia-Zepeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaw-Chyn","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han A.","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Michael A.","family":"Gimbrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Luster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis W.","family":"Luscinskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF19546_CR1","doi-asserted-by":"publisher","first-page":"8264","DOI":"10.1073\/pnas.92.18.8264","volume":"92","author":"JD Smith","year":"1995","unstructured":"Smith, J. D. et al. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl Acad. Sci. USA 92, 8264\u20138268 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF19546_CR2","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/386292a0","volume":"386","author":"H Suzuki","year":"1997","unstructured":"Suzuki, H. et al. Arole for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292\u2013296 (1997).","journal-title":"Nature"},{"key":"BF19546_CR3","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1073\/pnas.94.9.4647","volume":"94","author":"S Fazio","year":"1997","unstructured":"Fazio, S. et al. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc. Natl Acad. Sci. USA 94, 4647\u20134652 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF19546_CR4","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1172\/JCI115411","volume":"88","author":"NA Nelken","year":"1991","unstructured":"Nelken, N. A., Coughlin, S. R., Gordon, D. & Wilcox, J. N. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88, 1121\u20131127 (1991).","journal-title":"J. Clin. Invest."},{"key":"BF19546_CR5","first-page":"1423","volume":"142","author":"AE Koch","year":"1993","unstructured":"Koch, A. E. et al. Enhanced production of the chemotactic cytokines interleukin-8 and monocyte chemoattractant protein-1 in human abdominal aortic aneurysms. Am. J. Pathol. 142, 1423\u20131431 (1993).","journal-title":"Am. J. Pathol."},{"key":"BF19546_CR6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1172\/JCI1195","volume":"101","author":"WA Boisvert","year":"1998","unstructured":"Boisvert, W. A., Santiago, R., Curtiss, L. K. & Terkeltaub, R. A. Aleukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J. Clin. Invest. 101, 353\u2013363 (1998).","journal-title":"J. Clin. Invest."},{"key":"BF19546_CR7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/29788","volume":"394","author":"L Boring","year":"1998","unstructured":"Boring, L., Goslin, J., Cleary, M. & Charo, I. Decreased lesion formation in CCR2\u2212\/\u2212 mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394, 894\u2013897 (1998).","journal-title":"Nature"},{"key":"BF19546_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0065-2776(08)60509-X","volume":"55","author":"M Baggiolini","year":"1994","unstructured":"Baggiolini, M., Dewald, B. & Moser, B. Interleukin-8 and related chemokines \u2014 CXC and CC chemokines. Adv. Immunol. 55, 97\u2013179 (1994).","journal-title":"Adv. Immunol."},{"key":"BF19546_CR9","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1161\/01.RES.82.8.871","volume":"82","author":"RE Gerszten","year":"1998","unstructured":"Gerszten, R. E. et al. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ. Res. 82, 871\u2013878 (1998).","journal-title":"Circ. Res."},{"key":"BF19546_CR10","doi-asserted-by":"publisher","first-page":"16404","DOI":"10.1074\/jbc.272.26.16404","volume":"272","author":"TA Berkhout","year":"1997","unstructured":"Berkhout, T. A. et al. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemoattractant protein (MCP) family that binds and signals through the CC chemokine receptor 2B. J. Biol. Chem. 272, 16404\u201316413 (1997).","journal-title":"J. Biol. Chem."},{"key":"BF19546_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","volume":"76","author":"TA Springer","year":"1994","unstructured":"Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301\u2013314 (1994).","journal-title":"Cell"},{"key":"BF19546_CR12","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1083\/jcb.134.4.1063","volume":"134","author":"C Weber","year":"1996","unstructured":"Weber, C., Alon, R., Moser, B. & Springer, T. A. Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis. J.Cell Biol. 134, 1063\u20131073 (1996).","journal-title":"J.Cell Biol."},{"key":"BF19546_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1074-7613(00)80682-2","volume":"4","author":"M Woldemar-Carr","year":"1996","unstructured":"Woldemar-Carr, M., Alon, R. & Springer, T. A. The C-C chemokine MCP-1 differentially modulates the avidity of \u03b21 and \u03b22 integrins on T lymphocytes. Immunity 4, 179\u2013187 (1996).","journal-title":"Immunity"},{"key":"BF19546_CR14","doi-asserted-by":"publisher","first-page":"9233","DOI":"10.1073\/pnas.84.24.9233","volume":"84","author":"T Yoshimura","year":"1987","unstructured":"Yoshimura, T. et al. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl Acad. Sci. USA 84, 9233\u20139237 (1987).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF19546_CR15","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.139.10.3474","volume":"139","author":"JM Schroder","year":"1987","unstructured":"Schroder, J. M., Mrowietz, U., Morita, E. & Christophers, E. Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J. Immunol. 139, 3474\u20133483 (1987).","journal-title":"J. Immunol."},{"key":"BF19546_CR16","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.4049\/jimmunol.153.12.5682","volume":"153","author":"A Chuntharapai","year":"1994","unstructured":"Chuntharapai, A., Lee, J., Hebert, C. A. & Kim, K. J. Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes. J. Immunol. 153, 5682\u20135688 (1994).","journal-title":"J. Immunol."},{"key":"BF19546_CR17","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/nm1196-1174","volume":"2","author":"BA Premack","year":"1996","unstructured":"Premack, B. A. & Schall, T. J. Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2, 1174\u20131178 (1996).","journal-title":"Nat. Med."},{"key":"BF19546_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/25348","volume":"396","author":"KA Jones","year":"1998","unstructured":"Jones, K. A. et al. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396, 674\u2013679 (1998).","journal-title":"Nature"},{"key":"BF19546_CR19","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1083\/jcb.125.6.1417","volume":"125","author":"FW Luscinskas","year":"1994","unstructured":"Luscinskas, F. W. et al. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J. Cell Biol. 125, 1417\u20131427 (1994).","journal-title":"J. Cell Biol."},{"key":"BF19546_CR20","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1161\/01.RES.79.6.1205","volume":"79","author":"R Gerszten","year":"1996","unstructured":"Gerszten, R. et al. Adhesion of memory lymphocytes to VCAM-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ. Res. 79, 1205\u20131215 (1996).","journal-title":"Circ. Res."},{"key":"BF19546_CR21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.4049\/jimmunol.161.2.933","volume":"161","author":"M Yoshida","year":"1997","unstructured":"Yoshida, M., Szente, B. E., Kiely, J.-M., Rosenzweig, A. & Gimbrone, M. A. Regulation of E-selectin phosphorylation during leukocyte adhesion: a novel outside-in signaling role for E-selectin. J.Immunol. 161, 933\u2013941 (1997).","journal-title":"J.Immunol."},{"key":"BF19546_CR22","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4049\/jimmunol.145.3.819","volume":"145","author":"N Graber","year":"1990","unstructured":"Graber, N. et al. Tcells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1. J. Immunol. 145, 819\u2013830 (1990).","journal-title":"J. Immunol."},{"key":"BF19546_CR23","doi-asserted-by":"publisher","first-page":"9238","DOI":"10.1073\/pnas.84.24.9238","volume":"84","author":"MP Bevilacqua","year":"1987","unstructured":"Bevilacqua, M. P., Prober, J. S., Mendrick, D. L., Cotran, R. S. & Gimbrone, M. A. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc. Natl Acad. Sci. USA 84, 9238\u20139242 (1987).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF19546_CR24","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.146.5.1617","volume":"146","author":"FW Luscinskas","year":"1991","unstructured":"Luscinskas, F. W. et al. Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J. Immunol. 146, 1617\u20131625 (1991).","journal-title":"J. Immunol."},{"key":"BF19546_CR25","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1091\/mbc.2.5.347","volume":"2","author":"DB Taichman","year":"1991","unstructured":"Taichman, D. B. et al. Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110\/VCAM-1. Cell Regul. 2, 347\u2013355 (1991).","journal-title":"Cell Regul."},{"key":"BF19546_CR26","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4049\/jimmunol.157.1.326","volume":"156","author":"FW Luscinskas","year":"1996","unstructured":"Luscinskas, F. W. et al. L- and P-selectins, but not CD49d (VLA4) integrins, mediate monocyte initial attachment to TNF-activated vascular endothelium in vitro. J. Immunol. 156, 326\u2013335 (1996).","journal-title":"J. Immunol."},{"key":"BF19546_CR27","doi-asserted-by":"publisher","first-page":"C384","DOI":"10.1152\/ajpcell.1992.262.2.C384","volume":"262","author":"J Shen","year":"1992","unstructured":"Shen, J., Luscinskas, F. W., Connolly, A., Dewey, C. F. J. & Gimbrone, M. A. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am. J. Physiol. 262, C384\u2013390 (1992).","journal-title":"Am. J. Physiol."},{"key":"BF19546_CR28","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1172\/JCI113718","volume":"82","author":"ME Wheeler","year":"1988","unstructured":"Wheeler, M. E., Luscinskas, F. W., Bevilacqua, M. P. & Gimbrone, M. A. Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. J. Clin. Invest. 82, 1211\u20131218 (1988).","journal-title":"J. Clin. Invest."},{"key":"BF19546_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0022-1759(80)80014-7","volume":"33","author":"W Falk","year":"1980","unstructured":"Falk, W., Goodwin, R. H. J & Leonard, E. J. A48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Meth. 33, 239\u2013247 (1980).","journal-title":"J. Immunol. Meth."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/19546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/19546","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/19546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T23:15:48Z","timestamp":1682032548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/19546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":29,"journal-issue":{"issue":"6729","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["BF19546"],"URL":"https:\/\/doi.org\/10.1038\/19546","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}