{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:09:50Z","timestamp":1765267790306},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4909","license":[{"start":{"date-parts":[[1963,11,1]],"date-time":"1963-11-01T00:00:00Z","timestamp":-194659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1963,11]]},"DOI":"10.1038\/200849a0","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T17:17:15Z","timestamp":1152119835000},"page":"849-851","source":"Crossref","is-referenced-by-count":18,"title":["Partial Agonists in the Central Nervous System"],"prefix":"10.1038","volume":"200","author":[{"given":"GLENDA M.","family":"LAYCOCK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"SHULMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF200849a0_CR1","first-page":"32","volume":"99","author":"EJ Ari\u00ebns","year":"1954","unstructured":"Ari\u00ebns, E. J., Arch. int. pharmacodyn., 99, 32 (1954).","journal-title":"Arch. int. pharmacodyn."},{"key":"BF200849a0_CR2","first-page":"379","volume":"11","author":"RP Stephenson","year":"1956","unstructured":"Stephenson, R. P., Brit. J. Pharmacol., 11, 379 (1956).","journal-title":"Brit. J. Pharmacol."},{"key":"BF200849a0_CR3","first-page":"21","volume":"154","author":"WDM Paton","year":"1961","unstructured":"Paton, W. D. M., Proc. Roy. Soc., B, 154, 21 (1961).","journal-title":"Proc. Roy. Soc."},{"key":"BF200849a0_CR4","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1021\/jo01220a001","volume":"3","author":"WJ Doran","year":"1939","unstructured":"Doran, W. J., and Shonle, H. A., J. Org. Chem., 3, 193 (1939).","journal-title":"J. Org. Chem."},{"key":"BF200849a0_CR5","first-page":"26","volume":"84","author":"PK Knoefel","year":"1945","unstructured":"Knoefel, P. K., J. Pharmacol., 84, 26 (1945).","journal-title":"J. Pharmacol."},{"key":"BF200849a0_CR6","first-page":"121","volume":"2","author":"TC Butler","year":"1950","unstructured":"Butler, T. C., Pharmacol. Rev., 2, 121 (1950).","journal-title":"Pharmacol. Rev."},{"key":"BF200849a0_CR7","first-page":"157","volume":"125","author":"CA Leonard","year":"1953","unstructured":"Leonard, C. A., and Harrisson, J. W. E., Amer. J. Pharm., 125, 157 (1953).","journal-title":"Amer. J. Pharm."},{"key":"BF200849a0_CR8","first-page":"131","volume-title":"The Serotonin Hypothesis About Mental Disease","author":"DW Woolley","year":"1962","unstructured":"Woolley, D. W., The Serotonin Hypothesis About Mental Disease, 131 (John Wiley and Sons, New York, 1962)."},{"key":"BF200849a0_CR9","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/178996a0","volume":"178","author":"TC Somers","year":"1956","unstructured":"Somers, T. C., Nature, 178, 996 (1956).","journal-title":"Nature"},{"key":"BF200849a0_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/icb.1958.37","volume":"36","author":"A Shulman","year":"1958","unstructured":"Shulman, A., and Laycock, G. M., Austral. J. Exp. Biol., 36, 347 (1958).","journal-title":"Austral. J. Exp. Biol."},{"key":"BF200849a0_CR11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1071\/CH9600129","volume":"13","author":"GJ Handley","year":"1960","unstructured":"Handley, G. J., Nelson, E. R., and Somers, T. C., Austral. J. Chem., 13, 129 (1960).","journal-title":"Austral. J. Chem."},{"key":"BF200849a0_CR12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/icb.1956.57","volume":"34","author":"A Shulman","year":"1956","unstructured":"Shulman, A., Austral. J. Exp. Biol., 34, 471 (1956).","journal-title":"Austral. J. Exp. Biol."},{"key":"BF200849a0_CR13","first-page":"299","volume-title":"Ciba Found. Symp., Enzymes and Drug Action","author":"A Shulman","year":"1962","unstructured":"Shulman, A., Ciba Found. Symp., Enzymes and Drug Action, 299 (J. and A. Churchill, Ltd., London, 1962)."},{"key":"BF200849a0_CR14","first-page":"339","volume":"21","author":"A Shulman","year":"1962","unstructured":"Shulman, A., Laycock, G. M., Shankly, K. H., and Wright, R. D., Fed. Proc., 21, 339 (1962).","journal-title":"Fed. Proc."},{"key":"BF200849a0_CR15","unstructured":"Shulman, A., and Laycock, G. M. (unpublished observations)."},{"key":"BF200849a0_CR16","unstructured":"Shulman, A., Proc. Roy. Austral. Chem. Soc. (in the press)."},{"key":"BF200849a0_CR17","first-page":"181","volume-title":"Pharmacological Basis of Therapeutics","author":"LS Goodman","year":"1955","unstructured":"Goodman, L. S., and Gilman, A., Pharmacological Basis of Therapeutics, 181 (The Macmillan Co., New York, 1955)."},{"key":"BF200849a0_CR18","first-page":"151","volume":"11","author":"EJ Ari\u00ebns","year":"1962","unstructured":"Ari\u00ebns, E. J., and Simonis, A. M., Acta Physiol. Pharmacol. Neerlandica, 11, 151 (1962).","journal-title":"Acta Physiol. Pharmacol. Neerlandica"},{"key":"BF200849a0_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.2042-7158.1963.tb12787.x","volume":"15","author":"JM van Rossum","year":"1963","unstructured":"van Rossum, J. M., J. Pharm. (Lond.), 15, 285 (1963).","journal-title":"J. Pharm. (Lond.)"},{"key":"BF200849a0_CR20","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/j.2042-7158.1956.tb12217.x","volume":"8","author":"AH Beckett","year":"1956","unstructured":"Beckett, A. H., Casy, A. F., and Harper, N. J., J. Pharm. (Lond.), 8, 874 (1956).","journal-title":"J. Pharm. (Lond.)"},{"key":"BF200849a0_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/j.2042-7158.1958.tb10298.x","volume":"10","author":"KW Anderson","year":"1958","unstructured":"Anderson, K. W., J. Pharm. (Lond.), 10, 242 (1958).","journal-title":"J. Pharm. (Lond.)"},{"key":"BF200849a0_CR22","first-page":"35","volume":"14","author":"JDP Graham","year":"1959","unstructured":"Graham, J. D. P., and Nicholls, P. J., Brit. J. Pharmacol., 14, 35 (1959).","journal-title":"Brit. J. Pharmacol."},{"key":"BF200849a0_CR23","first-page":"97","volume":"15","author":"RM Featherstone","year":"1963","unstructured":"Featherstone, R. M., and Muehlbaecher, C. A., Pharmacol. Rev., 15, 97 (1963).","journal-title":"Pharmacol. Rev."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/200849a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/200849a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/200849a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:06:11Z","timestamp":1638389171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/200849a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,11]]},"references-count":23,"journal-issue":{"issue":"4909","published-print":{"date-parts":[[1963,11]]}},"alternative-id":["BF200849a0"],"URL":"https:\/\/doi.org\/10.1038\/200849a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,11]]}}}