{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:02:48Z","timestamp":1758279768795},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5024","license":[{"start":{"date-parts":[[1966,2,1]],"date-time":"1966-02-01T00:00:00Z","timestamp":-123552000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1966,2]]},"DOI":"10.1038\/209691a0","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T00:33:17Z","timestamp":1152145997000},"page":"691-694","source":"Crossref","is-referenced-by-count":40,"title":["Identification of a Component of a Transport \u2018Carrier\u2019 System: Isolation of the Permease Expression of the Lac Operon of Escherichia coli"],"prefix":"10.1038","volume":"209","author":[{"given":"ALAN R.","family":"KOLBER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WILFRED D.","family":"STEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF209691a0_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.143.3609.955","volume":"143","author":"PG LeFevre","year":"1964","unstructured":"LeFevre, P. G., Habich, K. I., Hess, H. S., and Hudson, M. R., Science, 143, 143 (1964).","journal-title":"Science"},{"key":"BF209691a0_CR2","first-page":"133","volume-title":"Structure and Activity of Enzymes","author":"WD Stein","year":"1964","unstructured":"Stein, W. D., in Structure and Activity of Enzymes, 133 (Academic Press, 1964)."},{"key":"BF209691a0_CR3","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/191970a0","volume":"191","author":"PG LeFevre","year":"1961","unstructured":"LeFevre, P. G., Nature, 191, 970 (1961).","journal-title":"Nature"},{"key":"BF209691a0_CR4","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0021-9258(18)97594-0","volume":"240","author":"RL Post","year":"1965","unstructured":"Post, R. L., Sen, A. K., and Rosenthal, A. S., J. Biol. Chem., 240, 1437 (1965).","journal-title":"J. Biol. Chem."},{"key":"BF209691a0_CR5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1128\/MMBR.21.3.169-194.1957","volume":"21","author":"GN Cohen","year":"1957","unstructured":"Cohen, G. N., and Monod, J., Bacteriol. Rev., 21, 169 (1957).","journal-title":"Bacteriol. Rev."},{"key":"BF209691a0_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1101\/SQB.1961.026.01.024","volume":"26","author":"F Jacob","year":"1961","unstructured":"Jacob, F., and Monod, J., Cold Spring Harbor Symp., 26, 193 (1961).","journal-title":"Cold Spring Harbor Symp."},{"key":"BF209691a0_CR7","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/0006-3002(52)90227-8","volume":"9","author":"J Monod","year":"1952","unstructured":"Monod, J., Pappenheimer, A. M., and Cohen-Bazire, G., Biochim. Bicrphys. Acta, 9, 648 (1952).","journal-title":"Biochim. Bicrphys. Acta"},{"key":"BF209691a0_CR8","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0021-9258(18)69430-X","volume":"235","author":"J Majar","year":"1960","unstructured":"Majar, J., and Magasanik, B., J. Biol. Chem., 235, 1474 (1960).","journal-title":"J. Biol. Chem."},{"key":"BF209691a0_CR9","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/0006-3002(58)90015-5","volume":"29","author":"WR Sistrom","year":"1958","unstructured":"Sistrom, W. R., Biochim. Biophys. Acta, 29, 579 (1958).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF209691a0_CR10","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1021\/ac60094a004","volume":"26","author":"RM Bock","year":"1954","unstructured":"Bock, R. M., and Ling, N. S., Anal. Chem., 26, 1543 (1954).","journal-title":"Anal. Chem."},{"key":"BF209691a0_CR11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1128\/JB.60.4.381-392.1950","volume":"60","author":"J Lederberg","year":"1950","unstructured":"Lederberg, J., J. Bacteriol., 60, 381 (1950).","journal-title":"J. Bacteriol."},{"key":"BF209691a0_CR12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0021-9258(18)97606-4","volume":"240","author":"DH Alpers","year":"1965","unstructured":"Alpers, D. H., Appel, S. H., and Tomkins, G. M., J. Biol. Chem., 240, 10 (1965).","journal-title":"J. Biol. Chem."},{"key":"BF209691a0_CR13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/0006-3002(60)91281-6","volume":"38","author":"A Torriani","year":"1960","unstructured":"Torriani, A., Biochim. Biophys. Acta, 38, 460 (1960).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF209691a0_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0006-3002(59)90230-6","volume":"34","author":"DB Cowie","year":"1959","unstructured":"Cowie, D. B., Cohen, G. N., Bolton, E. T., and DeRobichon-Szulmajster, H., Biochim. Biophys. Acta, 34, 39 (1959).","journal-title":"Biochim. Biophys. Acta"},{"key":"BF209691a0_CR15","first-page":"56","volume-title":"Chromatography and Electrophoretic Techniques","author":"J Kohn","year":"1960","unstructured":"Kohn, J., in Chromatography and Electrophoretic Techniques, edit. by Smith, I., 2, 56 (W. Heinemann, Ltd., London, 1960)."},{"key":"BF209691a0_CR16","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0022-2836(61)80072-7","volume":"3","author":"F Jacob","year":"1961","unstructured":"Jacob, F., and Monod, J., J. Mol. Biol., 3, 318 (1961).","journal-title":"J. Mol. Biol."},{"key":"BF209691a0_CR17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/0006-291X(63)90492-3","volume":"13","author":"A Nishi","year":"1963","unstructured":"Nishi, A., and Zabin, I., Biochem. Biophys. Res. Comm., 13, 320 (1963).","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"BF209691a0_CR18","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1101\/SQB.1963.028.01.058","volume":"28","author":"I Zabin","year":"1963","unstructured":"Zabin, I., Cold Spring Harbor Symp., 28, 431 (1963).","journal-title":"Cold Spring Harbor Symp."},{"key":"BF209691a0_CR19","first-page":"448","volume":"88","author":"AH Maddy","year":"1964","unstructured":"Maddy, A. H., Biochim. Biophys. Acta, 88, 448 (1964).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/209691a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/209691a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/209691a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:45:18Z","timestamp":1638398718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/209691a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,2]]},"references-count":19,"journal-issue":{"issue":"5024","published-print":{"date-parts":[[1966,2]]}},"alternative-id":["BF209691a0"],"URL":"https:\/\/doi.org\/10.1038\/209691a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,2]]}}}