{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:40:26Z","timestamp":1775738426836,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"6740","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1038\/22124","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:41:22Z","timestamp":1027672882000},"page":"173-177","source":"Crossref","is-referenced-by-count":2560,"title":["Immunization with amyloid-\u03b2 attenuates Alzheimer-disease-like pathology in the PDAPP mouse"],"prefix":"10.1038","volume":"400","author":[{"given":"Dale","family":"Schenk","sequence":"first","affiliation":[]},{"given":"Robin","family":"Barbour","sequence":"additional","affiliation":[]},{"given":"Whitney","family":"Dunn","sequence":"additional","affiliation":[]},{"given":"Grace","family":"Gordon","sequence":"additional","affiliation":[]},{"given":"Henry","family":"Grajeda","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Guido","sequence":"additional","affiliation":[]},{"given":"Kang","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Jiping","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Kelly","family":"Johnson-Wood","sequence":"additional","affiliation":[]},{"given":"Karen","family":"Khan","sequence":"additional","affiliation":[]},{"given":"Dora","family":"Kholodenko","sequence":"additional","affiliation":[]},{"given":"Mike","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Zhenmei","family":"Liao","sequence":"additional","affiliation":[]},{"given":"Ivan","family":"Lieberburg","sequence":"additional","affiliation":[]},{"given":"Ruth","family":"Motter","sequence":"additional","affiliation":[]},{"given":"Linda","family":"Mutter","sequence":"additional","affiliation":[]},{"given":"Ferdie","family":"Soriano","sequence":"additional","affiliation":[]},{"given":"George","family":"Shopp","sequence":"additional","affiliation":[]},{"given":"Nicki","family":"Vasquez","sequence":"additional","affiliation":[]},{"given":"Christopher","family":"Vandevert","sequence":"additional","affiliation":[]},{"given":"Shannan","family":"Walker","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Wogulis","sequence":"additional","affiliation":[]},{"given":"Ted","family":"Yednock","sequence":"additional","affiliation":[]},{"given":"Dora","family":"Games","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Seubert","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1999,7,8]]},"reference":[{"key":"BF22124_CR1","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1001\/archneur.55.9.1174","volume":"55","author":"BT Hyman","year":"1998","unstructured":"Hyman, B. T. New neuropathological criteria for Alzheimer disease. Arch. Neurol. 55, 1174\u20131176 (1998).","journal-title":"Arch. Neurol."},{"key":"BF22124_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1006\/nbdi.1996.0016","volume":"3","author":"RE Tanzi","year":"1996","unstructured":"Tanzi, R. E. et al. The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159\u2013168 (1996).","journal-title":"Neurobiol. Dis."},{"key":"BF22124_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/07853899609033127","volume":"28","author":"J Hardy","year":"1996","unstructured":"Hardy, J. New insights into the genetics of Alzheimer's disease. Ann. Med. 28, 255\u2013258 (1996).","journal-title":"Ann. Med."},{"key":"BF22124_CR4","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/360672a0","volume":"360","author":"M Citron","year":"1992","unstructured":"Citron, M. et al. Mutation of the \u03b2-amyloid precursor protein in familial Alzheimer's disease increases \u03b2-protein production. Nature 360, 672\u2013674 (1992).","journal-title":"Nature"},{"key":"BF22124_CR5","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"D Scheuner","year":"1996","unstructured":"Scheuner, D. et al. Secreted amyloid \u03b2-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864\u2013870 (1996).","journal-title":"Nature Med."},{"key":"BF22124_CR6","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1126\/science.8191290","volume":"264","author":"N Suzuki","year":"1994","unstructured":"Suzuki, N. et al. An increased percentage of long amyloid \u03b2 protein secreted by familial amyloid \u03b2 protein precursor (\u03b2 APP717) mutants. Science 264, 1336\u20131340 (1994).","journal-title":"Science"},{"key":"BF22124_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nm0197-67","volume":"3","author":"M Citron","year":"1997","unstructured":"Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid \u03b2-protein in both transfected cells and transgenic mice. Nature Med. 3, 67\u201372 (1997).","journal-title":"Nature Med."},{"key":"BF22124_CR8","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"DR Borchelt","year":"1996","unstructured":"Borchelt, D. R. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate A\u03b21-42\/1-40 ratio in vitro and in vivo. Neuron 17, 1005\u20131013 (1996).","journal-title":"Neuron"},{"key":"BF22124_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0896-6273(94)90458-8","volume":"13","author":"T Iwatsubo","year":"1994","unstructured":"Iwatsubo, T. et al. Visualization of A\u03b242(43) and A\u03b240 in senile plaques with end-specific A\u03b2 monoclonals: evidence that an initially deposited species is A\u03b242(43). Neuron 13, 45\u201353 (1994).","journal-title":"Neuron"},{"key":"BF22124_CR10","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/S0140-6736(05)79757-9","volume":"352","author":"CF Lippa","year":"1998","unstructured":"Lippa, C. F., Nee, L. E., Mori, H. refau>& St George-Hyslop, P. A\u03b2-42 deposition precedes other changes in PS-1 Alzheimer's disease. Lancet 352, 1117\u20131118 (1998).","journal-title":"Lancet"},{"key":"BF22124_CR11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/373523a0","volume":"373","author":"D Games","year":"1995","unstructured":"Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F \u03b2-amyloid precursor protein. Nature 373, 523\u2013527 (1995).","journal-title":"Nature"},{"key":"BF22124_CR12","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1073\/pnas.94.4.1550","volume":"94","author":"K Johnson-Wood","year":"1997","unstructured":"Johnson-Wood, K. et al. Amyloid precursor protein processing and A\u03b242 deposition in a transgenic mouse model of Alzheimer disease. Proc. Natl Acad. Sci. USA 94, 1550\u20131555 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF22124_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0304-3940(97)00196-1","volume":"225","author":"JS Liang","year":"1997","unstructured":"Liang, J. S. et al. Evidence for local production of acute phase response apolipoprotein serum amyloid A in Alzheimer's disease brain. Neurosci. Lett. 225, 73\u201376 (1997).","journal-title":"Neurosci. Lett."},{"key":"BF22124_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/mds.870120604","volume":"12","author":"EG McGeer","year":"1997","unstructured":"McGeer, E. G. refau>& McGeer, P. L. The role of the immune system in neurodegenerative disorders. Mov. Disorders 12, 855\u2013858 (1997).","journal-title":"Mov. Disorders"},{"key":"BF22124_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/359325a0","volume":"359","author":"P Seubert","year":"1992","unstructured":"Seubert, P. et al. Isolation and quantification of soluble Alzheimer's \u03b2-peptide from biological fluids. Nature 359, 325\u2013327 (1992).","journal-title":"Nature"},{"key":"BF22124_CR16","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/361260a0","volume":"361","author":"P Seubert","year":"1993","unstructured":"Seubert, P. et al. Secretion of \u03b2-amyloid precursor protein cleaved at the amino terminus of the \u03b2-amyloid peptide. Nature 361, 260\u2013263 (1993).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/22124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/22124","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/22124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:32:40Z","timestamp":1638390760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/22124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":16,"journal-issue":{"issue":"6740","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["BF22124"],"URL":"https:\/\/doi.org\/10.1038\/22124","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}