{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:59:47Z","timestamp":1767650387569},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5305","license":[{"start":{"date-parts":[[1971,7,1]],"date-time":"1971-07-01T00:00:00Z","timestamp":47174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1971,7]]},"DOI":"10.1038\/232017a0","type":"journal-article","created":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T06:26:51Z","timestamp":1122964011000},"page":"17-19","source":"Crossref","is-referenced-by-count":113,"title":["Prostaglandins and Aspirin"],"prefix":"10.1038","volume":"232","author":[{"given":"H. O. J.","family":"COLLIER","sequence":"first","affiliation":[]}],"member":"297","reference":[{"key":"BF232017a0_CR1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/224221a0","volume":"224","author":"VR Pickles","year":"1969","unstructured":"Pickles, V. R., Nature, 224, 221 (1969).","journal-title":"Nature"},{"key":"BF232017a0_CR2","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1126\/science.157.3787.382","volume":"157","author":"S Bergstr\u00f6m","year":"1967","unstructured":"Bergstr\u00f6m, S., Science, 157, 382 (1967).","journal-title":"Science"},{"key":"BF232017a0_CR3","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/j.1469-185X.1967.tb01532.x","volume":"32","author":"VR Pickles","year":"1967","unstructured":"Pickles, V. R., Biol. Rev., 32, 614 (1967).","journal-title":"Biol. Rev."},{"key":"BF232017a0_CR4","volume-title":"Prostaglandins","author":"USvon Euler","year":"1967","unstructured":"Euler, U. S. von, and Eliasson, R., Prostaglandins (Academic Press, New York and London, 1967)."},{"key":"BF232017a0_CR5","first-page":"1","volume":"20","author":"S Bergstr\u00f6m","year":"1968","unstructured":"Bergstr\u00f6m, S., Carlson, L. A., and Weeks, J. R., Pharmacol. Rev., 20, 1 (1968).","journal-title":"Pharmacol. Rev."},{"key":"BF232017a0_CR6","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1152\/physrev.1969.49.1.122","volume":"49","author":"EW Horton","year":"1969","unstructured":"Horton, E. W., Physiol. Rev., 49, 122 (1969).","journal-title":"Physiol. Rev."},{"key":"BF232017a0_CR7","unstructured":"Pickles, V. R. and Fitzpatrick, R. J. (eds.), Endogenous Substances Acting on the Myometrium, Mem. Soc. Endocrinol., 14 (1966)."},{"key":"BF232017a0_CR8","unstructured":"Bergstr\u00f6m, S. and Samuelsson, B. (eds.), Nobel Symp., 2: Prostaglandins (Almqvist and Wiksell, Stockholm, 1967)."},{"key":"BF232017a0_CR9","unstructured":"Ramwell, P. W., and Shaw, J. E. (eds.), Prostaglandins (Interscience, New York, 1968)."},{"key":"BF232017a0_CR10","doi-asserted-by":"crossref","unstructured":"Kinins and Prostaglandins, Proc. Roy. Soc. Med., 64, 1 (1971).","DOI":"10.1177\/003591577106400101"},{"key":"BF232017a0_CR11","doi-asserted-by":"crossref","unstructured":"Ramwell, P. W., and Shaw, J. E. (eds.), Prostaglandins, Ann. NY Acad. Sci., 180 (1971).","DOI":"10.1111\/j.1749-6632.1971.tb53181.x"},{"key":"BF232017a0_CR12","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/newbio231232a0","volume":"231","author":"JR Vane","year":"1971","unstructured":"Vane, J. R., Nature New Biology, 231, 232 (1971).","journal-title":"Nature New Biology"},{"key":"BF232017a0_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/newbio231237a0","volume":"231","author":"SH Ferreira","year":"1971","unstructured":"Ferreira, S. H., Moncada, S., and Vane, J. R., Nature New Biology, 231, 237 (1971).","journal-title":"Nature New Biology"},{"key":"BF232017a0_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/newbio231235a0","volume":"231","author":"JB Smith","year":"1971","unstructured":"Smith, J. B., and Willis, A. L., Nature New Biology, 231, 235 (1971).","journal-title":"Nature New Biology"},{"key":"BF232017a0_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S1054-3589(08)60566-9","volume":"7","author":"HOJ Collier","year":"1969","unstructured":"Collier, H. O. J., Adv. Pharmacol. Chemother., 7, 333 (1969).","journal-title":"Adv. Pharmacol. Chemother."},{"key":"BF232017a0_CR16","unstructured":"Collier, H. O. J., in Sci. Basis Med., 308 (1968)."},{"key":"BF232017a0_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/217069a0","volume":"217","author":"WJF Sweatman","year":"1968","unstructured":"Sweatman, W. J. F., and Collier, H. O. J., Nature, 217, 69 (1968).","journal-title":"Nature"},{"key":"BF232017a0_CR18","first-page":"363","volume-title":"Prostaglandins","author":"PJ Piper","year":"1971","unstructured":"Piper, P. J., and Vane, J. R., in Prostaglandins (edit. by Ramwell, P. W., and Shaw, J. E.), Ann. NY Acad. Sci., 180, 363 (1971)."},{"key":"BF232017a0_CR19","first-page":"321","volume-title":"Prostaglandins","author":"G Kaley","year":"1968","unstructured":"Kaley, G., and Weiner, R., in Prostaglandins (edit. by Ramwell, P. W., and Shaw, J. E.), 321 (Interscience, New York, 1968)."},{"key":"BF232017a0_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1476-5381.1971.tb09934.x","volume":"41","author":"P Crunkhorn","year":"1971","unstructured":"Crunkhorn, P., and Willis, A. L., Brit. J. Pharmacol., 41, 49 (1971).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1136\/bmj.2.5756.258","volume":"2","author":"MW Greaves","year":"1971","unstructured":"Greaves, M. W., S\u00f8ndergaard, J., and McDonald-Gibson, W., Brit. Med. J., 2, 258 (1971).","journal-title":"Brit. Med. J."},{"key":"BF232017a0_CR22","first-page":"201","volume":"23","author":"PA Berry","year":"1964","unstructured":"Berry, P. A., and Collier, H. O. J., Brit. J. Pharmacol., 23, 201 (1964).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.2042-7158.1969.tb08271.x","volume":"21","author":"GWL James","year":"1969","unstructured":"James, G. W. L., J. Pharm. Pharmacol., 21, 379 (1969).","journal-title":"J. Pharm. Pharmacol."},{"key":"BF232017a0_CR24","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1038\/219864a0","volume":"219","author":"HOJ Collier","year":"1968","unstructured":"Collier, H. O. J., and Sweatman, W. J. F., Nature, 219, 864 (1968).","journal-title":"Nature"},{"key":"BF232017a0_CR25","first-page":"255","volume":"17","author":"R Jaques","year":"1959","unstructured":"Jaques, R., Helv. Physiol. Acta, 17, 255 (1959).","journal-title":"Helv. Physiol. Acta"},{"key":"BF232017a0_CR26","unstructured":"Berry, P. A., thesis, Council for Academic Awards, London, 91 (1966)."},{"key":"BF232017a0_CR27","first-page":"137","volume":"26","author":"H Helfer","year":"1968","unstructured":"Helfer, H., and Jaques, R., Helv. Physiol. Acta, 26, 137 (1968).","journal-title":"Helv. Physiol. Acta"},{"key":"BF232017a0_CR28","first-page":"76P","volume":"207","author":"AS Milton","year":"1970","unstructured":"Milton, A. S., and Wendlandt, S., J. Physiol., 207, 76P (1970).","journal-title":"J. Physiol."},{"key":"BF232017a0_CR29","unstructured":"Milton, A. S., and Wendlandt, S., J. Physiol. (in the press)."},{"key":"BF232017a0_CR30","first-page":"215P","volume":"34","author":"AS Milton","year":"1968","unstructured":"Milton, A. S., and Wendlandt, S., Brit. J. Pharmacol., 34, 215P (1968).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/223029a0","volume":"223","author":"PJ Piper","year":"1969","unstructured":"Piper, P. J., and Vane, J. R., Nature, 223, 29 (1969).","journal-title":"Nature"},{"key":"BF232017a0_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/223035a0","volume":"223","author":"HOJ Collier","year":"1969","unstructured":"Collier, H. O. J., Nature, 223, 35 (1969).","journal-title":"Nature"},{"key":"BF232017a0_CR33","first-page":"626","volume":"30","author":"RA Bethel","year":"1971","unstructured":"Bethel, R. A., and Eakins, K. E., Fed. Proc., 30, 626 (1971) (abstract).","journal-title":"Fed. Proc."},{"key":"BF232017a0_CR34","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1136\/bmj.4.5685.723","volume":"4","author":"MF Cuthbert","year":"1969","unstructured":"Cuthbert, M. F., Brit. Med. J., 4, 723 (1969).","journal-title":"Brit. Med. J."},{"key":"BF232017a0_CR35","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/BF00619306","volume":"3","author":"H Herxheimer","year":"1971","unstructured":"Herxheimer, H., and Roetscher, I., Europ. J. Clin. Pharmacol., 3, 123 (1971).","journal-title":"Europ. J. Clin. Pharmacol."},{"key":"BF232017a0_CR36","first-page":"155","volume":"21","author":"HOJ Collier","year":"1963","unstructured":"Collier, H. O. J., and Lee, I. R., Brit. J. Pharmacol., 21, 155 (1963).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR37","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3181\/00379727-114-28768","volume":"114","author":"JF Emele","year":"1963","unstructured":"Emele, J. F., and Shanaman, J., Proc. Soc. Exp. Biol. Med., 114, 680 (1963).","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BF232017a0_CR38","first-page":"295","volume":"32","author":"HOJ Collier","year":"1968","unstructured":"Collier, H. O. J., Dinneen, L. C., Johnson, C. A., and Schneider, C., Brit. J. Pharmacol., 32, 295 (1968).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR39","first-page":"25","volume":"152","author":"RKS Lim","year":"1964","unstructured":"Lim, R. K. S., Guzman, F., Rodgers, D. W., Goto, K., Braun, C., Dickerson, C. D., and Engle, R. J., Arch. Intern. Pharmacodyn. Therap., 152, 25 (1964).","journal-title":"Arch. Intern. Pharmacodyn. Therap."},{"key":"BF232017a0_CR40","first-page":"10","volume-title":"Prostaglandins","author":"PW Ramwell","year":"1971","unstructured":"Ramwell, P. W., and Shaw, J. E., in Prostaglandins (edit. by Ramwell, P. W., and Shaw, J. E.), Ann. NY Acad. Sci., 180, 10 (1971)."},{"key":"BF232017a0_CR41","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/1921089b0","volume":"192","author":"H Herxheimer","year":"1961","unstructured":"Herxheimer, H., and Stresemann, E., Nature, 192, 1089 (1961).","journal-title":"Nature"},{"key":"BF232017a0_CR42","first-page":"553","volume-title":"Prostaglandins","author":"G Filshie","year":"1971","unstructured":"Filshie, G., in Prostaglandins (edit. by Ramwell, P. W., and Shaw, J. E.), Ann. NY Acad. Sci., 180, 553 (1971)."},{"key":"BF232017a0_CR43","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/220385a0","volume":"220","author":"M Eriksson","year":"1968","unstructured":"Eriksson, M., and Larson, K. S., Nature, 220, 385 (1968).","journal-title":"Nature"},{"key":"BF232017a0_CR44","first-page":"110","volume":"3","author":"F Berti","year":"1967","unstructured":"Berti, F., Kabir Naimzada, M., Lentati, R., Mantegazza, P., and Paoletti, R., Progr. Biochem. Pharmacol., 3, 110 (1967).","journal-title":"Progr. Biochem. Pharmacol."},{"key":"BF232017a0_CR45","first-page":"187","volume":"25","author":"A Bizzi","year":"1965","unstructured":"Bizzi, A., Garattini, S., and Veneroni, E., Brit. J. Pharmacol., 25, 187 (1965).","journal-title":"Brit. J. Pharmacol."},{"key":"BF232017a0_CR46","first-page":"410","volume-title":"Prostaglandins","author":"P Hedqvist","year":"1971","unstructured":"Hedqvist, P., in Prostaglandins (edit. by Ramwell, P. W., and Shaw, J. E.), Ann. NY Acad. Sci., 180, 410 (1971)."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/232017a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/232017a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/232017a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:01:04Z","timestamp":1638399664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/232017a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,7]]},"references-count":46,"journal-issue":{"issue":"5305","published-print":{"date-parts":[[1971,7]]}},"alternative-id":["BF232017a0"],"URL":"https:\/\/doi.org\/10.1038\/232017a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,7]]}}}