{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:52:00Z","timestamp":1779353520655,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6747","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1999,8]]},"DOI":"10.1038\/23730","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:41:22Z","timestamp":1027672882000},"page":"886-891","source":"Crossref","is-referenced-by-count":841,"title":["Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis"],"prefix":"10.1038","volume":"400","author":[{"given":"Xiao-Ming","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atan","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongge","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Zinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Klocke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.","family":"Korsmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF23730_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0092-8674(00)81589-5","volume":"94","author":"X Luo","year":"1998","unstructured":"Luo, X., Budihardjo, I., Zou, H., Slaughter, C. & Wang, X. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481\u2013490 (1998).","journal-title":"Cell"},{"key":"BF23730_CR2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0092-8674(00)81590-1","volume":"94","author":"H Li","year":"1998","unstructured":"Li, H., Zhu, H., Xu, C. J. & Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491\u2013501 (1998).","journal-title":"Cell"},{"key":"BF23730_CR3","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1074\/jbc.274.2.1156","volume":"274","author":"A Gross","year":"1999","unstructured":"Gross, A. et al. Caspase-cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1\/Fas death. J. Biol. Chem. 274, 1156\u20131163 (1999).","journal-title":"J. Biol. Chem."},{"key":"BF23730_CR4","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1128\/MCB.19.2.1381","volume":"19","author":"Z Han","year":"1999","unstructured":"Han, Z., Bhalla, K., Pantazis, P., Hendrickson, E. A. & Wyche, J. H. Cif (cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid. Mol. Cell. Biol. 19, 1381\u20131389 (1999).","journal-title":"Mol. Cell. Biol."},{"key":"BF23730_CR5","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.1074\/jbc.274.8.5053","volume":"274","author":"XM Sun","year":"1999","unstructured":"Sun, X. M. et al. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274, 5053\u20135060 (1999).","journal-title":"J. Biol. Chem."},{"key":"BF23730_CR6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0092-8674(00)80572-3","volume":"96","author":"J Chou","year":"1999","unstructured":"Chou, J., Li, H., Salvesen, G., Yuan, J. & Wagner, G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell 96, 615\u2013624 (1999).","journal-title":"Cell"},{"key":"BF23730_CR7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0092-8674(00)80573-5","volume":"96","author":"J McDonnell","year":"1999","unstructured":"McDonnell, J., Fushman, D., Milliman, C., Korsmeyer, S. & Cowburn, D. Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonist and antagonists. Cell 96, 625\u2013634 (1999).","journal-title":"Cell"},{"key":"BF23730_CR8","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1101\/gad.10.22.2859","volume":"10","author":"K Wang","year":"1996","unstructured":"Wang, K., Yin, X. M., Chao, D. T., Milliman, C. L. & Korsmeyer, S. J. BID: a novel BH3 domain-only death agonist. Genes Dev. 10, 2859\u20132869 (1996).","journal-title":"Genes Dev."},{"key":"BF23730_CR9","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/geno.1998.5489","volume":"53","author":"K Wang","year":"1998","unstructured":"Wang, K. et al. BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. Genomics 53, 235\u2013238 (1998).","journal-title":"Genomics"},{"key":"BF23730_CR10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","volume":"74","author":"LA Tartaglia","year":"1993","unstructured":"Tartaglia, L. A., Ayres, T. M., Wong, G. H. W. & Goeddel, D. V. Anovel domain within the 55\u2009kd TNF receptor signals cell death. Cell 74, 845\u2013853 (1993).","journal-title":"Cell"},{"key":"BF23730_CR11","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/S0960-9822(02)70706-9","volume":"6","author":"S Nagata","year":"1996","unstructured":"Nagata, S. Apoptosis: telling cells their time is up. Curr. Biol. 6, 1241\u20131243 (1996).","journal-title":"Curr. Biol."},{"key":"BF23730_CR12","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0092-8674(00)81265-9","volume":"85","author":"MP Boldin","year":"1996","unstructured":"Boldin, M. P., Goncharow, M., Goltsev, Y. V. & Wallach, D. Involvement of MACH, a novel MORT1\/FADD-interacting protease, in Fas\/APO-1- and TNF receptor-induced cell death. Cell 85, 803\u2013815 (1996).","journal-title":"Cell"},{"key":"BF23730_CR13","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","volume":"85","author":"M Muzio","year":"1996","unstructured":"Muzio, M. et al. FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/API-1) death-inducing signaling complex. Cell 85, 817\u2013827 (1996).","journal-title":"Cell"},{"key":"BF23730_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/364806a0","volume":"364","author":"J Ogasawara","year":"1993","unstructured":"Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature 364, 806\u2013809 (1993).","journal-title":"Nature"},{"key":"BF23730_CR15","doi-asserted-by":"publisher","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","volume":"272","author":"NA Thornberry","year":"1997","unstructured":"Thornberry, N. A. et al. Acombinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907\u201317911 (1997).","journal-title":"J. Biol. Chem."},{"key":"BF23730_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","volume":"86","author":"X Liu","year":"1996","unstructured":"Liu, X., Kim, C. N., Yang, J., Jemmerson, R. & Wang, X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147\u2013157 (1996).","journal-title":"Cell"},{"key":"BF23730_CR17","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1021\/bi9809268","volume":"38","author":"R Jemmerson","year":"1999","unstructured":"Jemmerson, R. et al. Aconformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles. Biochemistry 38, 3599\u20133609 (1999).","journal-title":"Biochemistry"},{"key":"BF23730_CR18","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1093\/emboj\/17.6.1675","volume":"17","author":"C Scaffidi","year":"1998","unstructured":"Scaffidi, C. et al. Two CD95 (APO-1\/Fas) signaling pathways. EMBO J. 17, 1675\u20131687 (1998).","journal-title":"EMBO J."},{"key":"BF23730_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0092-8674(00)80197-X","volume":"89","author":"L Xuesong","year":"1997","unstructured":"Xuesong, L., Zou, H., Slaughter, C. & Wang, X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175\u2013184 (1997).","journal-title":"Cell"},{"key":"BF23730_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/34112","volume":"391","author":"M Enari","year":"1998","unstructured":"Enari, M. et al. Acaspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature 391, 43\u201350 (1998).","journal-title":"Nature"},{"key":"BF23730_CR21","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/nm0196-80","volume":"2","author":"V Lacronique","year":"1996","unstructured":"Lacronique, V. et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nature Med. 2, 80\u201386 (1996).","journal-title":"Nature Med."},{"key":"BF23730_CR22","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1084\/jem.183.3.1031","volume":"183","author":"I Rodriguez","year":"1996","unstructured":"Rodriguez, I. et al. Abcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J. Exp. Med. 183, 1031\u20131036 (1996).","journal-title":"J. Exp. Med."},{"key":"BF23730_CR23","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","volume":"91","author":"P Li","year":"1997","unstructured":"Li, P. et al. Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479\u2013489 (1997).","journal-title":"Cell"},{"key":"BF23730_CR24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S1074-7613(00)80609-3","volume":"9","author":"EE Varfolomeev","year":"1998","unstructured":"Varfolomeev, E. E. et al. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas\/Apo1 and DR3 and is lethal prenatally. Immunity 9, 267\u2013276 (1998).","journal-title":"Immunity"},{"key":"BF23730_CR25","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0092-8674(00)81476-2","volume":"94","author":"K Kuida","year":"1998","unstructured":"Kuida, K. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94, 325\u2013337 (1998).","journal-title":"Cell"},{"key":"BF23730_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0092-8674(00)81477-4","volume":"94","author":"R Hakem","year":"1998","unstructured":"Hakem, R. et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94, 339\u2013352 (1998).","journal-title":"Cell"},{"key":"BF23730_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0092-8674(00)81732-8","volume":"94","author":"F Cecconi","year":"1998","unstructured":"Cecconi, F., Alvarezbolado, G., Meyer, B. I., Roth, K. A. & Gruss, P. Apaf1 (Ced-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727\u2013737 (1998).","journal-title":"Cell"},{"key":"BF23730_CR28","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S0092-8674(00)81733-X","volume":"94","author":"H Yoshida","year":"1998","unstructured":"Yoshida, H. et al. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739\u2013750 (1998).","journal-title":"Cell"},{"key":"BF23730_CR29","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","volume":"281","author":"JM Adams","year":"1998","unstructured":"Adams, J. M. & Cory, S. The Bcl-2 family: arbiters of cell survival. Science 281, 1322\u20131326 (1998).","journal-title":"Science"},{"key":"BF23730_CR30","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/sj.cdd.4400449","volume":"5","author":"A Srinivasan","year":"1998","unstructured":"Srinivasan, A. et al. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5, 1004\u20131016 (1998).","journal-title":"Cell Death Differ."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/23730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/23730","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/23730.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:39:29Z","timestamp":1638405569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/23730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":30,"journal-issue":{"issue":"6747","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["BF23730"],"URL":"https:\/\/doi.org\/10.1038\/23730","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}