{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:49:57Z","timestamp":1790783397196,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6706","license":[{"start":{"date-parts":[[1998,11,1]],"date-time":"1998-11-01T00:00:00Z","timestamp":909878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1998,11]]},"DOI":"10.1038\/23974","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T04:39:18Z","timestamp":1027658358000},"page":"92-96","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":208,"title":["Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus"],"prefix":"10.1038","volume":"396","author":[{"given":"Peter B.","family":"Rosenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Formanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Fitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huey","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Meier-Ewert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Skehel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don C.","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF23974_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0065-3527(08)60280-8","volume":"40","author":"G Herrler","year":"1991","unstructured":"Herrler, G. & Klenk, H.-D. Structure and function of the HEF glycoprotein of influenza C virus. Adv. Virus Res. 40, 213\u2013234 ((1991)).","journal-title":"Adv. Virus Res."},{"key":"BF23974_CR2","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nsb0395-218","volume":"2","author":"Y Wei","year":"1995","unstructured":"Wei, Y.et al. Anovel variant of the catalytic triad in the Streptomyces scabies esterase. Nature Struct. Biol. 2, 218\u2013223 (1995).","journal-title":"Nature Struct. Biol."},{"key":"BF23974_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/385089a0","volume":"385","author":"YS Ho","year":"1997","unstructured":"Ho, Y. S.et al. Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. Nature 385, 89\u201393 (1997).","journal-title":"Nature"},{"key":"BF23974_CR4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0042-6822(88)90512-0","volume":"166","author":"W Luytjes","year":"1988","unstructured":"Luytjes, W., Bredenbeek, P. J., Noten, A. F., Horzinek, M. C. & Spaan, W. J. Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus. Virology 166, 415\u2013422 (1988).","journal-title":"Virology"},{"key":"BF23974_CR5","volume-title":"Crystallographic Studies of the Influenza C Virus Surface Glycoprotein","author":"PB Rosenthal","year":"1996","unstructured":"Rosenthal, P. B. Crystallographic Studies of the Influenza C Virus Surface Glycoprotein. Thesis, Harvard Univ., (1996)."},{"key":"BF23974_CR6","doi-asserted-by":"crossref","first-page":"12501","DOI":"10.1016\/S0021-9258(18)42305-8","volume":"267","author":"C Herrler","year":"1992","unstructured":"Herrler, C.et al. Asynthetic sialic acid analogue is recognized by influenza C virus as a receptor determinant but is resistant to the receptor-destroying enzyme. J. Biol. Chem. 267, 12501\u201312505 (1992).","journal-title":"J. Biol. Chem."},{"key":"BF23974_CR7","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/0968-0896(96)00123-X","volume":"4","author":"W Fitz","year":"1996","unstructured":"Fitz, W., Rosenthal, P. B. & Wong, C.-H. Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O -acetylsialic acid esterase from influenza C virus. Biorg. Med. Chem. 4, 1349\u20131353 (1996).","journal-title":"Biorg. Med. Chem."},{"key":"BF23974_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1006\/viro.1997.8526","volume":"232","author":"MB Eisen","year":"1997","unstructured":"Eisen, M. B., Sabesan, S., Skehel, J. J. & Wiley, D. C. Binding of the influenza A virus to cell-surface receptors: Structures of five hemagglutinin-sialyloligosaccharide complexes determined by X-ray crystallography. Virology 232, 19\u201331 (1997).","journal-title":"Virology"},{"key":"BF23974_CR9","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/333426a0","volume":"333","author":"W Weis","year":"1988","unstructured":"Weis, W.et al. Structure of the influenza haemagglutinin complexed with its receptor, sialic acid. Nature 333, 426\u2013431 (1988).","journal-title":"Nature"},{"key":"BF23974_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/304076a0","volume":"304","author":"GN Rogers","year":"1983","unstructured":"Rogers, G. N.et al. Single amino-acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature 304, 76\u201378 (1983).","journal-title":"Nature"},{"key":"BF23974_CR11","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1016\/S0021-9258(17)38475-2","volume":"261","author":"GN Rogers","year":"1986","unstructured":"Rogers, G. N., Herrler, G., Paulson, J. C. & Klenk, H.-D. Influenza C virus uses 9-O -acetyl-N -acetylneuaminic acid as a high affinity receptor determinant for attachment to cells. J. Biol. Chem. 261, 5947\u20135951 (1986).","journal-title":"J. Biol. Chem."},{"key":"BF23974_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/371037a0","volume":"371","author":"PA Bullough","year":"1994","unstructured":"Bullough, P. A., Hughson, F. M., Skehel, J. J. & Wiley, D. C. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371, 37\u201343 (1994).","journal-title":"Nature"},{"key":"BF23974_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/373167a0","volume":"373","author":"J Grimes","year":"1995","unstructured":"Grimes, J., Basak, A. K., Roy, P. & Stuart, D. The crystal structure of bluetongue virus VP7. Nature 373, 167\u2013170 (1995).","journal-title":"Nature"},{"key":"BF23974_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/0042-6822(74)90187-1","volume":"57","author":"A Scheid","year":"1974","unstructured":"Scheid, A. & Choppin, P. Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus. Virology 57, 475\u2013490 (1974).","journal-title":"Virology"},{"key":"BF23974_CR15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/j.1460-2075.1992.tb05090.x","volume":"11","author":"SR Pollard","year":"1992","unstructured":"Pollard, S. R., Rosa, M. D., Rosa, J. J. & Wiley, D. C. Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region. EMBO J. 11, 585\u2013591 (1992).","journal-title":"EMBO J."},{"key":"BF23974_CR16","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1128\/JVI.71.12.9722-9731.1997","volume":"71","author":"R Wyatt","year":"1997","unstructured":"Wyatt, R.et al. Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein. J. Virol. 71, 9722\u20139731 (1997).","journal-title":"J. Virol."},{"key":"BF23974_CR17","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1128\/JVI.65.4.2119-2123.1991","volume":"65","author":"E Helseth","year":"1991","unstructured":"Helseth, E., Olshevsky, U., Furman, C. & Sodroski, J. Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein. J. Virol. 65, 2119\u20132123 (1991).","journal-title":"J. Virol."},{"key":"BF23974_CR18","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1073\/pnas.79.4.968","volume":"79","author":"JJ Skehel","year":"1982","unstructured":"Skehel, J. J.et al. Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proc. Natl Acad. Sci. USA 79, 968\u2013972 (1982).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BF23974_CR19","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1107\/S0907444996005021","volume":"52","author":"PB Rosenthal","year":"1996","unstructured":"Rosenthal, P. B.et al. Crystallization and preliminary X-ray diffraction studies of the influenza C virus glycoprotein. Acta Crystallogr. D 52, 1041\u20131045 (1996).","journal-title":"Acta Crystallogr. D"},{"key":"BF23974_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski, Z. & Minor W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307\u2013326 (1997).","journal-title":"Methods Enzymol."},{"key":"BF23974_CR21","unstructured":"Collaborative Computational Project No. 4, the CCP4 Suite: Programs for Protein Crystallography. Acta Crystallogr. D 50, 760\u2013763 (1994)."},{"key":"BF23974_CR22","first-page":"34","volume-title":"Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography","author":"KD Cowtan","year":"1994","unstructured":"Cowtan, K. D. Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography 31, 34\u201338 (1994)."},{"key":"BF23974_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/291090a0","volume":"291","author":"M Go","year":"1981","unstructured":"Go, M. Correlation of DNA exonic regions with protein structural units in haemoglobin. Nature 291, 90\u201392 (1981).","journal-title":"Nature"},{"key":"BF23974_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1006\/jmbi.1993.1489","volume":"233","author":"L Holm","year":"1993","unstructured":"Holm, L. & Sander, C. Protein structure comparison by alignment of distance matrices. J. Mol. Biol. 233, 123\u2013138 (1993).","journal-title":"J. Mol. Biol."},{"key":"BF23974_CR25","first-page":"9","volume-title":"Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography","author":"GJ Kleywegt","year":"1994","unstructured":"Kleywegt, G. J. & Jones, T. A. Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography 31, 9\u201314 ((1994))."},{"key":"BF23974_CR26","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0263-7855(87)80010-3","volume":"5","author":"M Carson","year":"1987","unstructured":"Carson, M. Ribbon models of macromolecules. J. Mol. Graph. Modelg 5, 103\u2013106 (1987).","journal-title":"J. Mol. Graph. Modelg"},{"key":"BF23974_CR27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/prot.340110407","volume":"11","author":"A Nicholls","year":"1991","unstructured":"Nicholls, A., Sharp, K. A. & Honig, B. Protein folding and association: insights from interfacial and thermodynamic properties of hydrocarbons. Proteins Struct. Funct. Genet. 11, 281\u2013296 (1991).","journal-title":"Proteins Struct. Funct. Genet."},{"key":"BF23974_CR28","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S1093-3263(97)00021-1","volume":"15","author":"RM Esnouf","year":"1997","unstructured":"Esnouf, R. M. An extensively modified version of Molscript which includes greatly enhanced coloring capabilities. J. Mol. Graph. Modelg 15, 132\u2013134 (1997).","journal-title":"J. Mol. Graph. Modelg"},{"key":"BF23974_CR29","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0076-6879(97)77028-9","volume":"276","author":"EA Merritt","year":"1997","unstructured":"Merritt, E. A. & Bacon, D. J. Raster3D: photorealistic molecular graphics. Methods Enzymol. 276, 505\u2013524 (1997).","journal-title":"Methods Enzymol."},{"key":"BF23974_CR30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/0263-7855(93)87009-T","volume":"11","author":"SV Evans","year":"1993","unstructured":"Evans, S. V. SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules. J. Mol. Graph. Modelg 11, 134\u2013138 (1993).","journal-title":"J. Mol. Graph. Modelg"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/23974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/23974","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/23974.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T19:49:27Z","timestamp":1638388167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/23974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11]]},"references-count":30,"journal-issue":{"issue":"6706","published-print":{"date-parts":[[1998,11]]}},"alternative-id":["BF23974"],"URL":"https:\/\/doi.org\/10.1038\/23974","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,11]]},"assertion":[{"value":"2 July 1998","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 1998","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}