{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:05Z","timestamp":1791235145075,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1038\/2477","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:48:04Z","timestamp":1027673284000},"page":"175-179","source":"Crossref","is-referenced-by-count":460,"title":["Evidence for a prostate cancer susceptibility locus on the X chromosome."],"prefix":"10.1038","volume":"20","author":[{"suffix":"*","given":"Jianfeng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diha","family":"Freije","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Nusskern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ewing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wilkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piroska","family":"Bujnovszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Steven","family":"Bova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Johanna","family":"Schleutker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Mika","family":"Matikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuvo","family":"Tammela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapio","family":"Visakorpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli-P.","family":"Kallioniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Rebecca","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Daniel","family":"Schaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Blute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Thibodeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Henrik","family":"Gr\u00f6nberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Emanuelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Erik","family":"Damber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn-Anders","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"*","given":"Jeffrey","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Bailey-Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Carpten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gillanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Amundson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Kainu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Freas-Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Baffoe-Bonnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Van Aucken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Sood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brownstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Trent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1098_175_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3322\/canjclin.48.1.6","volume":"48","author":"SH Landis","year":"1998","unstructured":"Landis, S.H., Murray, T., Bolden, S. & Wingo, P.A. Cancer statistics, 1998. CA Cancer J. Clin. 48, 6\u2013 29 (1998).","journal-title":"CA Cancer J. Clin"},{"key":"BFng1098_175_CR2","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1126\/science.274.5291.1371","volume":"274","author":"JR Smith","year":"1996","unstructured":"Smith, J.R.  et al. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search. Science 274, 1371\u20131374 (1996).","journal-title":"Science"},{"key":"BFng1098_175_CR3","first-page":"4707","volume":"57","author":"H Gr\u00f6nberg","year":"1997","unstructured":"Gr\u00f6nberg, H.  et al. Early age at diagnosis in families proving evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1.  Cancer Res. 57, 4707\u20134709 (1997).","journal-title":"Cancer Res."},{"key":"BFng1098_175_CR4","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1093\/jnci\/89.13.955","volume":"89","author":"KA Cooney","year":"1997","unstructured":"Cooney, K.A.  et al. Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J. Natl Cancer Inst. 89, 955\u2013 959 (1997).","journal-title":"J. Natl Cancer Inst."},{"key":"BFng1098_175_CR5","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1093\/jnci\/89.24.1893","volume":"89","author":"CL Hsieh","year":"1997","unstructured":"Hsieh, C.L.  et al. Prostate cancer susceptibility locus on chromosome 1q: a confirmatory study. J. Natl Cancer Inst. 89, 1893\u2013 1894 (1997).","journal-title":"J. Natl Cancer Inst."},{"key":"BFng1098_175_CR6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1086\/514853","volume":"61","author":"RA McIndoe","year":"1997","unstructured":"McIndoe, R.A.  et al. Linkage analysis of 49 high-risk families does not support a common familial prostate cancer-susceptibility gene at 1q24-25.  Am. J. Hum. Genet. 61, 347\u2013353 (1997).","journal-title":"Am. J. Hum. Genet"},{"key":"BFng1098_175_CR7","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1086\/301745","volume":"62","author":"RA Eeles","year":"1998","unstructured":"Eeles, R.A.  et al. Linkage analysis of chromosome 1q markers in 136 prostate cancer families. Am. J. Hum. Genet. 62, 653\u2013658 (1998).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1098_175_CR8","doi-asserted-by":"publisher","first-page":",1416","DOI":"10.1086\/301879","volume":"62","author":"P Berthon","year":"1998","unstructured":"Berthon, P.  et al. Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43. Am. J. Hum. Genet. 62,1416\u20131424 (1998).","journal-title":"Am. J. Hum. Genet"},{"key":"BFng1098_175_CR9","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1073\/pnas.89.8.3367","volume":"89","author":"BS Carter","year":"1992","unstructured":"Carter, B.S., Beaty, T.H., Steinberg, G.D., Childs, B. & Walsh P.C. Mendelian inheritance of familial prostate cancer.  Proc. Natl Acad. Sci. USA 89, 3367\u2013 3371 (1992).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_175_CR10","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/oxfordjournals.aje.a009313","volume":"146","author":"H Gr\u00f6nberg","year":"1997","unstructured":"Gr\u00f6nberg, H., Damber, L., Damber, J.E. & Iselius, L. Segregation analysis of prostate cancer in Sweden: support for dominant inheritance.  Am. J. Epidemiol. 146, 552\u2013557 (1997).","journal-title":"Am. J. Epidemiol."},{"key":"BFng1098_175_CR11","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1086\/301862","volume":"62","author":"DJ Schaid","year":"1998","unstructured":"Schaid, D.J., McDonnell, S.K., Blute, M.L. & Thibodeau, S.N. Evidence for autosomal dominant inheritance of prostate cancer.  Am. J. Hum Genet. 62, 1425\u20131438 (1998).","journal-title":"Am. J. Hum Genet."},{"key":"BFng1098_175_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/1097-0142(196007\/08)13:4<739::AID-CNCR2820130414>3.0.CO;2-E","volume":"13","author":"CM Woolf","year":"1960","unstructured":"Woolf, C.M. An investigation of the familial aspects of carcinoma of the prostate.  Cancer 13, 361\u2013364 ( 1960).","journal-title":"Cancer"},{"key":"BFng1098_175_CR13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nm0295-99","volume":"1","author":"SA Narod","year":"1995","unstructured":"Narod, S.A.  et al. The impact of family history on early detection of prostate cancer. Nature Med. 1, 99\u2013 101 (1995).","journal-title":"Nature Med."},{"key":"BFng1098_175_CR14","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/oxfordjournals.aje.a117495","volume":"141","author":"AS Whittemore","year":"1997","unstructured":"Whittemore, A.S. Xet al. Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am. J. Epidemiol . 141, 732\u2013740 ( 1997).","journal-title":"Am. J. Epidemiol"},{"key":"BFng1098_175_CR15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nm0895-827","volume":"1","author":"KR Monroe","year":"1995","unstructured":"Monroe, K.R.  et al. Evidence of an X-linked or recessive genetic component to prostate cancer risk. Nature Med. 1, 827 \u2013829 (1995).","journal-title":"Nature Med."},{"key":"BFng1098_175_CR16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/ijc.2910600315","volume":"60","author":"RB Hayes","year":"1995","unstructured":"Hayes, R.B.  et al. Prostate cancer risk in U.S. blacks and whites with a family history of cancer. Int. J. Cancer 60, 361 \u2013364 (1995).","journal-title":"Int. J. Cancer"},{"key":"BFng1098_175_CR17","volume-title":"Handbook of Human Genetic Linkage","author":"JD Terwilliger","year":"1994","unstructured":"Terwilliger, J.D. & Ott, J. Handbook of Human Genetic Linkage. (Johns Hopkins University Press, Baltimore, 1994)."},{"key":"BFng1098_175_CR18","first-page":"252","volume":"53","author":"RW Cottingham  Jr","year":"1993","unstructured":"Cottingham Jr, R.W., Idury, R.M. & Schaffer, A.A. Faster sequential genetic linkage computations. Am. J. Hum. Genet. 53, 252 \u2013263 (1993).","journal-title":"Am. J. Hum. Genet"},{"key":"BFng1098_175_CR19","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1073\/pnas.81.11.3443","volume":"81","author":"GM Lathrop","year":"1984","unstructured":"Lathrop, G.M., Lalouel, J.M., Julier, C. & Ott, J. Strategies for multilocus linkage analysis in humans. Proc. Natl Acad. Sci. USA 81, 3443\u20133446 ( 1984).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_175_CR20","volume-title":"Analysis of Human Genetic Linkage","author":"J Ott","year":"1991","unstructured":"Ott, J. Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1991)."},{"key":"BFng1098_175_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng1195-241","volume":"11","author":"ES Lander","year":"1995","unstructured":"Lander, E.S. & Kruglayk, L. Genetic dissection of complex traits: guideline for interpreting and reporting linkage results. Nature Genet. 11, 241\u2013247 ( 1995).","journal-title":"Nature Genet."},{"key":"BFng1098_175_CR22","first-page":"1194","volume":"57","author":"JL Stanford","year":"1997","unstructured":"Stanford, J.L.  et al. Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. Cancer Res. 57, 1194\u20131198 (1997).","journal-title":"Cancer Res"},{"key":"BFng1098_175_CR23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF00184606","volume":"14","author":"JM Hakimi","year":"1996","unstructured":"Hakimi, J.M., Rondinelli, R.H., Schoenberg, M.P. & Barrack, E.R. Androgen-receptor gene structure and function in prostate cancer.  World J. Urol. 14, 329\u2013337 (1996).","journal-title":"World J. Urol."},{"key":"BFng1098_175_CR24","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1073\/pnas.94.7.3320","volume":"94","author":"E Giovannucci","year":"1997","unstructured":"Giovannucci, E.  et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc. Natl Acad. Sci. USA 94, 3320\u20133325 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_175_CR25","first-page":"1937","volume":"55","author":"RA Irvine","year":"1995","unstructured":"Irvine, R.A., Yu, M.C., Ross, R.K. & Coetzee, G.A. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res. 55, 1937\u20131940 (1995).","journal-title":"Cancer Res."},{"key":"BFng1098_175_CR26","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1073\/pnas.84.8.2363","volume":"84","author":"ES Lander","year":"1987","unstructured":"Lander, E.S. & Green, P. Construction of multilocus genetic linkage maps in humans. Proc. Natl Acad. Sci. USA 84 , 2363\u20132367 (1987).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_175_CR27","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1006\/geno.1996.0436","volume":"36","author":"A Collins","year":"1996","unstructured":"Collins, A., Teague, J., Keats, B.J. & Morton, N.E. Linkage map integration . Genomics 36, 157\u2013162 (1996).","journal-title":"Genomics"},{"key":"BFng1098_175_CR28","first-page":"1347","volume":"58","author":"L Kruglayk","year":"1996","unstructured":"Kruglayk, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric linkage analysis: A unified multipoint approach . Am. J. Hum. Genet. 58, 1347\u2013 1363 (1996).","journal-title":"Am. J. Hum. Genet."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1098_175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_175","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:48:23Z","timestamp":1638402503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1098_175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["BFng1098_175"],"URL":"https:\/\/doi.org\/10.1038\/2477","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}