{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:01Z","timestamp":1791348121706,"version":"4.3.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1038\/2491","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:48:04Z","timestamp":1027673284000},"page":"184-188","source":"Crossref","is-referenced-by-count":309,"title":["Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH"],"prefix":"10.1038","volume":"20","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Coin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Marinoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Rodolfo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Fribourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Maria","family":"Pedrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Egly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFng1098_184_CR1","doi-asserted-by":"publisher","first-page":"8658","DOI":"10.1073\/pnas.94.16.8658","volume":"94","author":"E Taylor","year":"1997","unstructured":"Taylor, E. et al. Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair\/transcription gene. Proc. Natl Acad. Sci. USA 94, 8658\u2013 8663 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_184_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/363114a0","volume":"363","author":"D Bootsma","year":"1993","unstructured":"Bootsma, D. & Hoeijmakers, J.H.J. DNA repair. Engagement with transcription. Nature 363, 114\u2013 115 (1993).","journal-title":"Nature"},{"key":"BFng1098_184_CR3","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/0092-8674(94)90039-6","volume":"79","author":"R Roy","year":"1994","unstructured":"Roy, R. et al. The MO15 cell cycle kinase is ssociated with the TFIIH transcription-DNA repair factor. Cell 79, 1093\u2013 1101 (1994).","journal-title":"Cell"},{"key":"BFng1098_184_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/374280a0","volume":"374","author":"H Serizawa","year":"1995","unstructured":"Serizawa, H. et al. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature 374, 280\u2013 282 (1995).","journal-title":"Nature"},{"key":"BFng1098_184_CR5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/374283a0","volume":"374","author":"R Shiekhattar","year":"1995","unstructured":"Shiekhattar, R. et al. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374, 283\u2013 287 (1995).","journal-title":"Nature"},{"key":"BFng1098_184_CR6","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.8465201","volume":"260","author":"L Schaeffer","year":"1993","unstructured":"Schaeffer, L. et al. DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. Science 260, 58\u2013 63 (1993).","journal-title":"Science"},{"key":"BFng1098_184_CR7","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1002\/j.1460-2075.1994.tb06522.x","volume":"13","author":"L Schaeffer","year":"1994","unstructured":"Schaeffer, L. et al. The ERCC2\/DNA repair protein is associated with the class II BTF2\/TFIIH transcription factor. EMBO J. 13, 2388\u20132392 (1994).","journal-title":"EMBO J."},{"key":"BFng1098_184_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/367091a0","volume":"367","author":"SN Guzder","year":"1994","unstructured":"Guzder, S.N. et al. DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II. Nature 367, 91\u201394 (1994).","journal-title":"Nature"},{"key":"BFng1098_184_CR9","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/369578a0","volume":"369","author":"SN Guzder","year":"1994","unstructured":"Guzder, S.N., Sung, P., Bailly, V., Prakash, L. & Prakash, S. RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcription. Nature 369, 578\u2013581 (1994).","journal-title":"Nature"},{"key":"BFng1098_184_CR10","doi-asserted-by":"crossref","first-page":"20940","DOI":"10.1016\/S0021-9258(18)54801-8","volume":"266","author":"M Gerard","year":"1991","unstructured":"Gerard, M. et al. Purification and interaction properties of the human RNA poylmerase B(II) general transcription factor BTF2. J. Biol. Chem 266, 20940\u201320945 (1991).","journal-title":"J. Biol. Chem"},{"key":"BFng1098_184_CR11","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1074\/jbc.273.2.1092","volume":"273","author":"GS Winkler","year":"1998","unstructured":"Winkler, G.S. et al. Affinity purification of human DNA repair\/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein. J. Biol. Chem. 273, 1092\u20131098 (1998).","journal-title":"J. Biol. Chem."},{"key":"BFng1098_184_CR12","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1073\/pnas.84.24.8951","volume":"84","author":"P Sung","year":"1987","unstructured":"Sung, P., Prakash, L., Matson, S.W. & Prakash, S. RAD3 protein of Saccharomyces cerevisiae is a DNA helicase. Proc. Natl Acad. Sci. USA 84, 8951\u2013 8955 (1987).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_184_CR13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/365852a0","volume":"365","author":"P Sung","year":"1993","unstructured":"Sung, P. et al. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature 365, 852\u2013855 (1993).","journal-title":"Nature"},{"key":"BFng1098_184_CR14","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1093\/nar\/22.20.4095","volume":"22","author":"L Ma","year":"1994","unstructured":"Ma, L., Siemssen, E.D., Noteborn, M.H.M. & van der Eb, A.J. The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibit DNA helicase activity. Nucleic Acids Res. 22, 4095\u20134102 (1994).","journal-title":"Nucleic Acids Res."},{"key":"BFng1098_184_CR15","doi-asserted-by":"publisher","first-page":"6482","DOI":"10.1073\/pnas.93.13.6482","volume":"93","author":"JT Reardon","year":"1996","unstructured":"Reardon, J.T. et al. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2\/CAK and TFIIH. Proc. Natl Acad. Sci. USA 93, 6482\u20136487 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_184_CR16","doi-asserted-by":"publisher","first-page":"6488","DOI":"10.1073\/pnas.93.13.6488","volume":"93","author":"R Drapkin","year":"1996","unstructured":"Drapkin, R., Le Roy, G., Cho, H., Akoulitchev, S. & Reinberg, D. Human cyclin-dependent kinase-activating kinase exists in three distinct complexes. Proc. Natl Acad. Sci. USA 93, 6488\u20136493 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFng1098_184_CR17","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1093\/emboj\/16.7.1628","volume":"16","author":"M Rossignol","year":"1997","unstructured":"Rossignol, M., Kolb-Cheynel, I. & Egly, J.M. Substrate specificity of the cdk-activating kinase (CAK) is altered upon assocation with TFIIH. EMBO J. 16, 1628\u20131637 (1997).","journal-title":"EMBO J."},{"key":"BFng1098_184_CR18","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1002\/j.1460-2075.1988.tb03193.x","volume":"7","author":"P Sung","year":"1988","unstructured":"Sung, P., Higgins, D., Prakash, L. & Prakash, S. Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP. EMBO J. 7, 3263\u20133269 (1988).","journal-title":"EMBO J."},{"key":"BFng1098_184_CR19","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1021\/bi9524124","volume":"35","author":"N Iyer","year":"1996","unstructured":"Iyer, N., Reagan, M.S., Wu, K.J., Canagarajah, B. & Friedberg, E.C. Interactions involving the human RNA polymerase II transcription factor\/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein. Biochemistry 35, 2157\u2013 2167 (1996).","journal-title":"Biochemistry"},{"key":"BFng1098_184_CR20","doi-asserted-by":"publisher","first-page":"23465","DOI":"10.1074\/jbc.272.38.23465","volume":"272","author":"RD Wood","year":"1997","unstructured":"Wood, R.D. Nucleotide excision repair in mammalian cells. J. Biol. Chem. 272, 23465\u201323468 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFng1098_184_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/S0968-0004(00)89088-X","volume":"20","author":"AR Lehmann","year":"1995","unstructured":"Lehmann, A.R. Nucleotide excision repair and the link with transcription. Trends Biochem. Sci. 20, 402\u2013405 (1995).","journal-title":"Trends Biochem. Sci."},{"key":"BFng1098_184_CR22","doi-asserted-by":"publisher","first-page":"6559","DOI":"10.1093\/emboj\/16.21.6559","volume":"16","author":"E Evans","year":"1997","unstructured":"Evans, E., Moggs, J.G., Hwang, J.R., Egly, J.-M. & Wood, R.D. Mechanism of open complex and dual incision formation by human nucleotide excision repair factors. EMBO J. 16, 6559\u20136573 (1997).","journal-title":"EMBO J."},{"key":"BFng1098_184_CR23","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/jcs.76.1.115","volume":"76","author":"RT Johnson","year":"1985","unstructured":"Johnson, R.T., Squires, S., Ellion, G.C., Koch, G.L.E. & Rainbow, A.J. Xeroderma pigmentosum D-HeLa hybrids with low and high ultraviolet sensitivity associated with normal and diminished DNA repair ability, respectively. J. Cell Sci. 76, 115\u2013133 (1985).","journal-title":"J. Cell Sci."},{"key":"BFng1098_184_CR24","first-page":"72","volume":"60","author":"L B\u00fcrglen","year":"1997","unstructured":"B\u00fcrglen, L. et al. The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large scale deletions associated with ann disease. Am. J. Hum. Genet. 60, 72\u201379 (1997).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1098_184_CR25","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1101\/gad.6.12b.2463","volume":"6","author":"H Yoon","year":"1992","unstructured":"Yoon, H., Miller, S.P., Pabich, E.K. & Donahue, T.F. SSL1, a suppressor of a HIS4 5\u00b4-UTR stem-loop mutation, is essential for transclation initiation and affects UV resistance in yeast. Genes Dev. 6, 2463\u20132477 (1992).","journal-title":"Genes Dev."},{"key":"BFng1098_184_CR26","volume-title":"Baculovirus Expression Vectors. A Laboratory Manual","author":"DR O'Reilly","year":"1992","unstructured":"O'Reilly, D.R., Miller, L.K. & Luckow, V.A. Baculovirus Expression Vectors. A Laboratory Manual (W.H. Freeman, New York, 1992)."},{"key":"BFng1098_184_CR27","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1016\/S0021-9258(17)36958-2","volume":"269","author":"R Roy","year":"1994","unstructured":"Roy, R. et al. The DNA-dependent ATPase activity associated with the class II transcription factor BTF2\/TFIIH. J. Biol. Chem. 269 , 9826\u20139832 (1994).","journal-title":"J. Biol. Chem."}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1098_184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_184","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:55:45Z","timestamp":1638402945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1098_184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["BFng1098_184"],"URL":"https:\/\/doi.org\/10.1038\/2491","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}