{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:42:16Z","timestamp":1767886936834,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Genet"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1038\/2510","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T08:48:04Z","timestamp":1027673284000},"page":"198-202","source":"Crossref","is-referenced-by-count":304,"title":["Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA"],"prefix":"10.1038","volume":"20","author":[{"given":"P. Hemachandra","family":"Reddy","sequence":"first","affiliation":[]},{"given":"Maya","family":"Williams","sequence":"additional","affiliation":[]},{"given":"Vinod","family":"Charles","sequence":"additional","affiliation":[]},{"given":"Lisa","family":"Garrett","sequence":"additional","affiliation":[]},{"given":"Lisa","family":"Pike-Buchanan","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"William O.","family":"Whetsell","sequence":"additional","affiliation":[]},{"given":"Georgina","family":"Miller","sequence":"additional","affiliation":[]},{"given":"Danilo A.","family":"Tagle","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BFng1098_198_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"JP Vonsattel","year":"1985","unstructured":"Vonsattel, J.P.  et al. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44, 559\u2013 577 (1985).","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"BFng1098_198_CR2","volume-title":"Huntington's Disease","author":"SE Folstein","year":"1990","unstructured":"Folstein, S.E.  Huntington's Disease (Johns Hopkins University Press, Baltimore, 1990)."},{"key":"BFng1098_198_CR3","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0304-3940(91)90583-F","volume":"133","author":"JC Hedreen","year":"1991","unstructured":"Hedreen, J.C., Peyser, C.E., Folstein, S.E. & Ross, C.A. Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease. Neurosci. Lett. 133, 257\u2013 261 (1991).","journal-title":"Neurosci. Lett"},{"key":"BFng1098_198_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1136\/jnnp.56.5.487","volume":"56","author":"E Spargo","year":"1993","unstructured":"Spargo, E., Everall, I.P. & Lantos, P.L. Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infection. J. Neurol. Neurosurg. Psychiatry  56, 487\u2013491 ( 1993).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"BFng1098_198_CR5","doi-asserted-by":"crossref","unstructured":"The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell  72, 971\u2013983 (1993).","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"BFng1098_198_CR6","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/ng0893-398","volume":"4","author":"SE Andrew","year":"1993","unstructured":"Andrew, S.E.  et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nature Genet.  4, 398\u2013403 (1993).","journal-title":"Nature Genet"},{"key":"BFng1098_198_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/ng0893-387","volume":"4","author":"M Duyao","year":"1993","unstructured":"Duyao, M. et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet. 4, 387\u2013 392 (1993).","journal-title":"Nature Genet"},{"key":"BFng1098_198_CR8","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/hmg\/2.10.1547","volume":"2","author":"OC Stine","year":"1993","unstructured":"Stine, O.C.  et al. Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15. Hum. Mol. Genet . 2, 1547\u20131549 ( 1993).","journal-title":"Hum. Mol. Genet"},{"key":"BFng1098_198_CR9","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","volume":"11","author":"SH Li","year":"1993","unstructured":"Li, S.H. et al. Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11, 985\u2013 993 (1993).","journal-title":"Neuron"},{"key":"BFng1098_198_CR10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/ng1193-259","volume":"5","author":"TV Strong","year":"1993","unstructured":"Strong, T.V.  et al. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nature Genet.  5, 259\u2013265 (1993).","journal-title":"Nature Genet"},{"key":"BFng1098_198_CR11","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","volume":"14","author":"AH Sharp","year":"1995","unstructured":"Sharp, A.H.  et al. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron 14, 1065\u2013 1074 (1995).","journal-title":"Neuron"},{"key":"BFng1098_198_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini, L.  et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.  Cell 87, 493\u2013506 ( 1996).","journal-title":"Cell"},{"key":"BFng1098_198_CR13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S0092-8674(00)80464-X","volume":"91","author":"JM Ordway","year":"1997","unstructured":"Ordway, J.M.  et al. Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.  Cell 91, 753\u2013764 ( 1997).","journal-title":"Cell"},{"key":"BFng1098_198_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/hmg\/5.4.481","volume":"5","author":"JD Wood","year":"1996","unstructured":"Wood, J.D., MacMillan, J.C., Harper, P.S., Lowenstein, P.R. & Jones, A.L. Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Hum. Mol. Genet.  5, 481\u2013487 (1996).","journal-title":"Hum. Mol. Genet"},{"key":"BFng1098_198_CR15","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ng1297-404","volume":"17","author":"JK White","year":"1997","unstructured":"White, J.K.  et al. Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nature Genet.  17, 404\u2013410 (1997).","journal-title":"Nature Genet"},{"key":"BFng1098_198_CR16","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"KBJ Franklin","year":"1997","unstructured":"Franklin, K.B.J. & Paxinos, G. The Mouse Brain in Stereotaxic Coordinates (Academic Press, San Diego, 1997)."},{"key":"BFng1098_198_CR17","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1097\/00001756-199505090-00026","volume":"6","author":"M Dragunow","year":"1995","unstructured":"Dragunow, M.  et al. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport  6, 1053\u20131057 ( 1995).","journal-title":"Neuroreport"},{"key":"BFng1098_198_CR18","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1523\/JNEUROSCI.15-05-03775.1995","volume":"15","author":"C Portera-Cailliau","year":"1995","unstructured":"Portera-Cailliau, C., Hedreen, J.C., Price, D.L. & Koliatsos, K.E. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J. Neurosci. 15, 3775\u2013 3787 (1995).","journal-title":"J. Neurosci"},{"key":"BFng1098_198_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1006\/exnr.1995.1029","volume":"133","author":"LB Thomas","year":"1995","unstructured":"Thomas, L.B.  et al. DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp. Neurol. 133, 265\u2013272 (1995).","journal-title":"Exp. Neurol"},{"key":"BFng1098_198_CR20","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"SW Davies","year":"1997","unstructured":"Davies, S.W.  et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.  Cell 90, 537\u2013548 ( 1997).","journal-title":"Cell"},{"key":"BFng1098_198_CR21","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"M DiFiglia","year":"1997","unstructured":"DiFiglia, M.  et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990\u20131993 (1997).","journal-title":"Science"},{"key":"BFng1098_198_CR22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0896-6273(00)80943-5","volume":"19","author":"HL Paulson","year":"1997","unstructured":"Paulson, H.L.  et al. Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3. Neuron 19, 333\u2013344 (1997).","journal-title":"Neuron"},{"key":"BFng1098_198_CR23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/40153","volume":"389","author":"PJ Skinner","year":"1997","unstructured":"Skinner, P.J.  et al. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature 389, 971\u2013974 (1997).","journal-title":"Nature"},{"key":"BFng1098_198_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0149-7634(96)00027-9","volume":"21","author":"CV Borlongan","year":"1997","unstructured":"Borlongan, C.V., Koutouzis, T.K. & Sanberg, P.R. 3-Nitropropionic acid animal model and Huntington's disease. Neurosci. Biobehav. Rev. 21, 289 \u2013293 (1997).","journal-title":"Neurosci. Biobehav. Rev"},{"key":"BFng1098_198_CR25","first-page":"1202","volume":"60","author":"RR Brinkman","year":"1997","unstructured":"Brinkman, R.R., Mezei, M.M., Theilmann, J., Almqvist, E. & Hayden, M.R. The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size.  Am. J. Hum. Genet. 60, 1202\u20131210 (1997).","journal-title":"Am. J. Hum. Genet."},{"key":"BFng1098_198_CR26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1006\/exnr.1997.6441","volume":"144","author":"CM Kosinski","year":"1997","unstructured":"Kosinski, C.M.  et al. Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneurons. Exp. Neurol.  144, 239\u2013247 (1997).","journal-title":"Exp. Neurol"},{"key":"BFng1098_198_CR27","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0955-0674(97)80009-9","volume":"9","author":"PS Reddy","year":"1997","unstructured":"Reddy, P.S. & Housman, D.E. The complex pathology of trinucleotide repeats. Curr. Opin. Cell Biol. 9, 364\u2013 372 (1997).","journal-title":"Curr. Opin. Cell Biol"},{"key":"BFng1098_198_CR28","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/40159","volume":"389","author":"A Matilla","year":"1997","unstructured":"Matilla, A.  et al. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1. Nature 389, 974\u2013 978 (1997).","journal-title":"Nature"},{"key":"BFng1098_198_CR29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/hmg\/4.3.465","volume":"4","author":"YS Jou","year":"1995","unstructured":"Jou, Y.S. & Myers, R.M. Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein. Hum. Mol. Genet. 4, 465\u2013 469 (1995).","journal-title":"Hum. Mol. Genet"},{"key":"BFng1098_198_CR30","doi-asserted-by":"publisher","first-page":"8121","DOI":"10.1074\/jbc.272.13.8121","volume":"272","author":"YF Liu","year":"1997","unstructured":"Liu, Y.F., Deth, R.C. & Devys, D.E. SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes. J. Biol. Chem.  272, 8121\u20138124 (1997).","journal-title":"J. Biol. Chem"}],"container-title":["Nature Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ng1098_198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_198","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ng1098_198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T21:09:12Z","timestamp":1684444152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ng1098_198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["BFng1098_198"],"URL":"https:\/\/doi.org\/10.1038\/2510","relation":{},"ISSN":["1061-4036","1546-1718"],"issn-type":[{"value":"1061-4036","type":"print"},{"value":"1546-1718","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}