{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:55:50Z","timestamp":1758279350075},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5521","license":[{"start":{"date-parts":[[1975,9,1]],"date-time":"1975-09-01T00:00:00Z","timestamp":178761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1975,9]]},"DOI":"10.1038\/257060a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T20:48:26Z","timestamp":1123102106000},"page":"60-62","source":"Crossref","is-referenced-by-count":76,"title":["Genetic heterogeneity in GM1-gangliosidosis"],"prefix":"10.1038","volume":"257","author":[{"given":"H.","family":"GALJAARD","sequence":"first","affiliation":[]},{"given":"A.","family":"HOOGEVEEN","sequence":"additional","affiliation":[]},{"given":"W.","family":"KEIJZER","sequence":"additional","affiliation":[]},{"given":"H. A.","family":"DE WIT-VERBEEK","sequence":"additional","affiliation":[]},{"given":"A. J. J.","family":"REUSER","sequence":"additional","affiliation":[]},{"given":"MAE","family":"WAN HO","sequence":"additional","affiliation":[]},{"given":"D.","family":"ROBINSON","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1975,9,1]]},"reference":[{"key":"BF257060a0_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.160.3831.1002","volume":"160","author":"S Okada","year":"1968","unstructured":"Okada, S., and O'Brien, J. S., Science, 160, 1002\u20131004 (1968).","journal-title":"Science"},{"key":"BF257060a0_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1212\/WNL.20.1.23","volume":"20","author":"LS Wolfe","year":"1970","unstructured":"Wolfe, L. S., Callahan, J., Fawcett, J. S., Andermann, F., and Scriver, C. R., Neurology, 20, 23\u201344 (1970).","journal-title":"Neurology"},{"key":"BF257060a0_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-1-4757-4429-3_2","volume-title":"Advances in Human Genetics","author":"JS O'Brien","year":"1972","unstructured":"O'Brien, J. S., in Advances in Human Genetics (edit. by Harris, H., and Hirschhorn, K.), 3, 39\u201398 (Plenum, New York, 1972)."},{"key":"BF257060a0_CR4","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1001\/archneur.1974.00490390082010","volume":"31","author":"JA Lowden","year":"1974","unstructured":"Lowden, J. A., Callahan, J. W., Norman, M. G., Thain, M., and Pritchard, J. S., Archs. Neurol, 31, 200\u2013203 (1974).","journal-title":"Archs. Neurol"},{"key":"BF257060a0_CR5","first-page":"563","volume":"26","author":"L Pinsky","year":"1974","unstructured":"Pinsky, L., Miller, J., Stanfield, B., Watters, G., and Wolfe, L. S., Am. J. hum. Genet., 26, 563\u2013577 (1974).","journal-title":"Am. J. hum. Genet."},{"key":"BF257060a0_CR6","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/S0140-6736(74)90984-2","volume":"ii","author":"MCB Loonen","year":"1974","unstructured":"Loonen, M. C. B., Lugt, van der L., and Franke, C. L., Lancet, ii, 785 (1974).","journal-title":"Lancet"},{"key":"BF257060a0_CR7","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/2281093b0","volume":"228","author":"L Pinsky","year":"1970","unstructured":"Pinsky, L., Powell, E., and Callahan, J., Nature, 228, 1093\u20131095 (1970).","journal-title":"Nature"},{"key":"BF257060a0_CR8","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0021-9258(19)42804-4","volume":"249","author":"Y Suzuki","year":"1974","unstructured":"Suzuki, Y., and Suzuki, K., J. biol. Chem., 249, 2113\u20132117 (1974).","journal-title":"J. biol. Chem."},{"key":"BF257060a0_CR9","unstructured":"O'Brien, J. S., Clin. Genet. (in the press)."},{"key":"BF257060a0_CR10","first-page":"80","volume":"238","author":"EA Weerd-Kastelein","year":"1972","unstructured":"Weerd-Kastelein, E. A., de, Keijzer, W., and Bootsma, D., Nature, 238, 80\u201383 (1972).","journal-title":"Nature"},{"key":"BF257060a0_CR11","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/0014-4827(74)90515-1","volume":"87","author":"H Galjaard","year":"1974","unstructured":"Galjaard, H., Hoogeveen, A., Wit-Verbeek, H. A. de, Reuser, A. J. J., Keijzer, W., Westerveld, A., and Bootsma, D., Expl Cell Res., 87, 444\u2013448 (1974).","journal-title":"Expl Cell Res."},{"key":"BF257060a0_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/250580a0","volume":"250","author":"GH Thomas","year":"1974","unstructured":"Thomas, G. H., Taylor, H. A., Miller, C. S., Axelman, J., and Migeon, B. R., Nature, 250, 580\u2013582 (1974).","journal-title":"Nature"},{"key":"BF257060a0_CR13","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/205640a0","volume":"105","author":"H Harris","year":"1965","unstructured":"Harris, H., and Watkins, J. F., Nature, 105, 640\u2013646 (1965).","journal-title":"Nature"},{"key":"BF257060a0_CR14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265\u2013275 (1951).","journal-title":"J. biol. Chem."},{"key":"BF257060a0_CR15","doi-asserted-by":"crossref","unstructured":"Galjaard, H., Hoogeveen, A., Keijzer, W., Wit-Verbeek, H. A. de, and Vlek-Noot, C., Histochem. J., 491\u2013509 (1974).","DOI":"10.1007\/BF01003266"},{"key":"BF257060a0_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1042\/bj1360351","volume":"136","author":"MW Ho","year":"1973","unstructured":"Ho, M. W., Cheetham, P., and Robinson, D., Biochem. J., 136, 351\u2013359 (1973).","journal-title":"Biochem. J."},{"key":"BF257060a0_CR17","first-page":"35","volume-title":"Enzyme Therapy in Lysosomal Storage Disease","author":"H Galjaard","year":"1974","unstructured":"Galjaard, H., Reuser, A. J. J., Heukels-Dully, M. J., Hoogeveen, A., Keijzer, W., Wit-Verbeek, H. A. de, and Niermeijer, M. F., in Enzyme Therapy in Lysosomal Storage Disease (edit. by Tager, J. M., Hooghwinkel, G. J. M., and Daems, W. T.), 35\u201351 (North Holland, Amsterdam, 1974)."},{"key":"BF257060a0_CR18","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/BF01012433","volume":"6","author":"H Galjaard","year":"1974","unstructured":"Galjaard, H., Hoogstraten, J. J. van, Josselin de Jong, J. E. de, and Muldcr, M. P., Histochem J., 6, 409\u2013429 (1974).","journal-title":"Histochem J."},{"key":"BF257060a0_CR19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/0014-4827(65)90403-9","volume":"38","author":"D Killander","year":"1965","unstructured":"Killander, D., and Zetterberg, A., Expl Cell Res., 38, 272\u2013284 (1965).","journal-title":"Expl Cell Res."},{"key":"BF257060a0_CR20","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/0003-9861(73)90465-7","volume":"159","author":"AGW Norden","year":"1973","unstructured":"Norden, A. G. W., and O'Brien, J. S., Archs. Biochem., 159, 383\u2013392 (1973).","journal-title":"Archs. Biochem."},{"key":"BF257060a0_CR21","doi-asserted-by":"crossref","first-page":"7969","DOI":"10.1016\/S0021-9258(19)42060-7","volume":"249","author":"AGW Norden","year":"1974","unstructured":"Norden, A. G. W., Tennant, L., and O'Brien, J. S., J. biol. Chem., 249, 7969\u20137976 (1974).","journal-title":"J. biol. Chem."},{"key":"BF257060a0_CR22","first-page":"683","volume":"26","author":"M Meisler","year":"1974","unstructured":"Meisler, M., and Ratazzi, M. C., Am. J. hum. Genet., 26, 683\u2013691 (1974).","journal-title":"Am. J. hum. Genet."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/257060a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/257060a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/257060a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:14:44Z","timestamp":1684282484000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/257060a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,9]]},"references-count":22,"journal-issue":{"issue":"5521","published-print":{"date-parts":[[1975,9]]}},"alternative-id":["BF257060a0"],"URL":"https:\/\/doi.org\/10.1038\/257060a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,9]]}}}