{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:26:46Z","timestamp":1771874806531,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5529","license":[{"start":{"date-parts":[[1975,10,1]],"date-time":"1975-10-01T00:00:00Z","timestamp":181353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1975,10]]},"DOI":"10.1038\/257758a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T17:53:28Z","timestamp":1123091608000},"page":"758-763","source":"Crossref","is-referenced-by-count":108,"title":["Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes"],"prefix":"10.1038","volume":"257","author":[{"given":"Louis T. J.","family":"Delbaere","sequence":"first","affiliation":[]},{"given":"Wendy L. B.","family":"Hutcheon","sequence":"additional","affiliation":[]},{"given":"Michael N. G.","family":"James","sequence":"additional","affiliation":[]},{"given":"William E.","family":"Thiessen","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF257758a0_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1042\/bj1010229","volume":"101","author":"BS Hartley","year":"1966","unstructured":"Hartley, B. S., and Kauffman, D. L., Biochem. J., 101, 229\u2013231 (1966).","journal-title":"Biochem. J."},{"key":"BF257758a0_CR2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/0304-4165(66)90258-3","volume":"130","author":"B Meloun","year":"1966","unstructured":"Meloun, B., et al., Biochim. biophys. Acta, 130, 543\u2013545 (1966).","journal-title":"Biochim. biophys. Acta"},{"key":"BF257758a0_CR3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/221337a0","volume":"221","author":"DM Blow","year":"1969","unstructured":"Blow, D. M., Birktoft, J. J., and Hartley, B. S., Nature, 221, 337\u2013340 (1969).","journal-title":"Nature"},{"key":"BF257758a0_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/218343a0","volume":"218","author":"LB Smillie","year":"1968","unstructured":"Smillie, L. B., Furka, A., Nagabhushan, N., Stevenson, K. J., and Parkes, C. O., Nature, 218, 343\u2013346 (1968).","journal-title":"Nature"},{"key":"BF257758a0_CR5","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1073\/pnas.52.4.884","volume":"52","author":"KA Walsh","year":"1964","unstructured":"Walsh, K. A., and Neurath, H., Proc. natn. Acad. Sci. U.S.A., 52, 884\u2013889 (1964).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF257758a0_CR6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/0006-291X(66)90162-8","volume":"24","author":"O Mikes","year":"1966","unstructured":"Mikes, O., Holeysovsky, V., Tom\u00e1sek, V., and Sorm, F., Biochem. biophys. Res. Commun., 24, 346\u2013353 (1966).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF257758a0_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1098\/rstb.1970.0010","volume":"257","author":"BS Hartley","year":"1970","unstructured":"Hartley, B. S., Phil. Trans. R. Soc., B 257, 77\u201386 (1970).","journal-title":"Phil. Trans. R. Soc."},{"key":"BF257758a0_CR8","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/225802a0","volume":"225","author":"DM Shotton","year":"1970","unstructured":"Shotton, D. M., and Hartley, B. S., Nature, 225, 802\u2013806 (1970).","journal-title":"Nature"},{"key":"BF257758a0_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0022-2836(72)90210-0","volume":"68","author":"JJ Birktoft","year":"1972","unstructured":"Birktoft, J. J., and Blow, D. M., J. molec. Biol., 68, 187\u2013240 (1972).","journal-title":"J. molec. Biol."},{"key":"BF257758a0_CR10","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/225811a0","volume":"225","author":"DM Shotton","year":"1970","unstructured":"Shotton, D. M., and Watson, H. C., Nature, 225, 811\u2013816 (1970).","journal-title":"Nature"},{"key":"BF257758a0_CR11","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0022-2836(74)90387-8","volume":"83","author":"RM Stroud","year":"1974","unstructured":"Stroud, R. M., Kay, L. M., and Dickerson, R. E., J. molec. Biol., 83, 185\u2013208 (1974).","journal-title":"J. molec. Biol."},{"key":"BF257758a0_CR12","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1038\/228438a0","volume":"228","author":"MOJ Olsen","year":"1970","unstructured":"Olsen, M. O. J., Nagabhushan, N., Dzwiniel, M., Smillie, L. B., and Whitaker, D. R., Nature, 228, 438\u2013442 (1970).","journal-title":"Nature"},{"key":"BF257758a0_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0014-5793(74)80412-6","volume":"47","author":"P Johnson","year":"1974","unstructured":"Johnson, P., and Smillie, L. B., FEBS Lett., 47, 1\u20136 (1974).","journal-title":"FEBS Lett."},{"key":"BF257758a0_CR14","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/S0006-291X(74)80396-7","volume":"61","author":"L Jur\u00e1sek","year":"1974","unstructured":"Jur\u00e1sek, L., et al., Biochem. biophys. Res. Commun., 61, 1095\u20131100 (1974).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF257758a0_CR15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/229202a0","volume":"229","author":"AD McLachlan","year":"1971","unstructured":"McLachlan, A. D., and Shotton, D. M., Nature, 229, 202\u2013205 (1971).","journal-title":"Nature"},{"key":"BF257758a0_CR16","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/221235a0","volume":"221","author":"CS Wright","year":"1969","unstructured":"Wright, C. S., Alden, R. A., and Kraut, J., Nature, 221, 235\u2013242 (1969).","journal-title":"Nature"},{"key":"BF257758a0_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1139\/o74-034","volume":"52","author":"PW Codding","year":"1974","unstructured":"Codding, P. W., et al., Can. J. Biochem. 52, 208\u2013220 (1974).","journal-title":"Can. J. Biochem."},{"key":"BF257758a0_CR18","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1107\/S0365110X59002274","volume":"12","author":"DM Blow","year":"1959","unstructured":"Blow, D. M., and Crick, F. H. C., Acta Crystallogr., 12, 794\u2013802 (1959).","journal-title":"Acta Crystallogr."},{"key":"BF257758a0_CR19","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/2011284a0","volume":"201","author":"BS Hartley","year":"1964","unstructured":"Hartley, B. S., Nature, 201, 1284\u20131287 (1964).","journal-title":"Nature"},{"key":"BF257758a0_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0022-2836(71)90116-1","volume":"57","author":"RE Dickerson","year":"1971","unstructured":"Dickerson, R. E., J. molec. Biol., 57, 1\u201315 (1971).","journal-title":"J. molec. Biol."},{"key":"BF257758a0_CR21","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1021\/bi00745a023","volume":"12","author":"A Tulinsky","year":"1973","unstructured":"Tulinsky, A., Vandlen, R. L., Morimoto, C. N., Mani, N. V., and Wright, L. H., Biochemistry, 12, 4185\u20134192 (1973).","journal-title":"Biochemistry"},{"key":"BF257758a0_CR22","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1021\/bi00715a006","volume":"13","author":"A Mavridis","year":"1974","unstructured":"Mavridis, A., Tulinsky, A., and Liebman, M. N., Biochemistry, 13, 3661\u20133666 (1974).","journal-title":"Biochemistry"},{"key":"BF257758a0_CR23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1101\/SQB.1972.036.01.015","volume":"36","author":"DM Shotton","year":"1971","unstructured":"Shotton, D. M., White, N. J., and Watson, H. C., Cold Spring Harb. Symp. quant. Biol., 36, 91\u2013105 (1971).","journal-title":"Cold Spring Harb. Symp. quant. Biol."},{"key":"BF257758a0_CR24","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/0006-291X(69)90792-X","volume":"34","author":"H Kaplan","year":"1969","unstructured":"Kaplan, H., and Dugas, H., Biochem. biophys. Res. Commun., 34, 681\u2013685 (1969).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF257758a0_CR25","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/214652a0","volume":"214","author":"BW Matthews","year":"1967","unstructured":"Matthews, B. W., Sigler, P. B., Henderson, R., and Blow, D. M., Nature, 214, 652\u2013656 (1967).","journal-title":"Nature"},{"key":"BF257758a0_CR26","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1016\/S0021-9258(19)45053-9","volume":"247","author":"S Siegal","year":"1972","unstructured":"Siegal, S., Brady, A. H., and Awad, W. M., J. biol. Chem., 247, 4155\u20134159 (1972).","journal-title":"J. biol. Chem."},{"key":"BF257758a0_CR27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0022-2836(75)90225-9","volume":"92","author":"C deHaen","year":"1975","unstructured":"deHaen, C., Neurath, H., and Teller, D. C., J. molec. Biol., 92, 225\u2013259 (1975).","journal-title":"J. molec. Biol."},{"key":"BF257758a0_CR28","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1021\/bi00811a022","volume":"9","author":"ST Freer","year":"1970","unstructured":"Freer, S. T., Kraut, J., Robertus, J. D., Wright, H. T., and Xuong Ng, H., Biochemistry, 9, 1997\u20132009 (1970).","journal-title":"Biochemistry"},{"key":"BF257758a0_CR29","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0022-2836(70)90434-1","volume":"54","author":"R Henderson","year":"1970","unstructured":"Henderson, R., J. molec. Biol., 54, 341\u2013354 (1970).","journal-title":"J. molec. Biol."},{"key":"BF257758a0_CR30","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1093\/oxfordjournals.jbchem.a130146","volume":"73","author":"Y Narahashi","year":"1973","unstructured":"Narahashi, Y., and Yoda, K., J. Biochem., 73, 831\u2013841 (1973).","journal-title":"J. Biochem."},{"key":"BF257758a0_CR31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1139\/o71-082","volume":"49","author":"P Johnson","year":"1971","unstructured":"Johnson, P., and Smillie, L. B., Can. J. Biochem., 49, 548\u2013562 (1971).","journal-title":"Can. J. Biochem."},{"key":"BF257758a0_CR32","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/0022-2836(72)90508-6","volume":"64","author":"AD McLachlan","year":"1972","unstructured":"McLachlan, A. D., J. molec Biol., 64, 417\u2013437 (1972).","journal-title":"J. molec Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/257758a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/257758a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/257758a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:19:20Z","timestamp":1684282760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/257758a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10]]},"references-count":32,"journal-issue":{"issue":"5529","published-print":{"date-parts":[[1975,10]]}},"alternative-id":["BF257758a0"],"URL":"https:\/\/doi.org\/10.1038\/257758a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,10]]}}}