{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:03:17Z","timestamp":1775581397840,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5585","license":[{"start":{"date-parts":[[1976,12,1]],"date-time":"1976-12-01T00:00:00Z","timestamp":218246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1976,12]]},"DOI":"10.1038\/264415a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T16:24:41Z","timestamp":1123086281000},"page":"415-420","source":"Crossref","is-referenced-by-count":345,"title":["Crystallographic structure studies of an IgG molecule and an Fc fragment"],"prefix":"10.1038","volume":"264","author":[{"given":"Robert","family":"Huber","sequence":"first","affiliation":[]},{"given":"Johann","family":"Deisenhofer","sequence":"additional","affiliation":[]},{"given":"Peter M.","family":"Colman","sequence":"additional","affiliation":[]},{"given":"Masaaki","family":"Matsushima","sequence":"additional","affiliation":[]},{"given":"Walter","family":"Palm","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"BF264415a0_CR1","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1021\/bi00818a009","volume":"9","author":"U Rutishauser","year":"1970","unstructured":"Rutishauser, U., Cunningham, B. A., Bennet, C., Konigsberg, W. H., and Edelman, G. M., Biochemistry, 9, 3171\u20133181 (1970).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR2","first-page":"174","volume":"1","author":"JB Fleischmann","year":"1972","unstructured":"Fleischmann, J. B., Pain, R. H., and Porter, R. R., Archs Biochem. Biophys. Suppl., 1, 174 (1972).","journal-title":"Archs Biochem. Biophys. Suppl."},{"key":"BF264415a0_CR3","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1146\/annurev.bi.44.070175.003231","volume":"44","author":"DR Davies","year":"1975","unstructured":"Davies, D. R., Padlan, E. A., and Segal, D. M., A. Rev. Biochem., 44, 639\u2013667 (1975).","journal-title":"A. Rev. Biochem."},{"key":"BF264415a0_CR4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0022-2836(76)80062-9","volume":"100","author":"PM Colman","year":"1976","unstructured":"Colman, P. M., Deisenhofer, J., Huber, R., and Palm, W., J. molec. Biol, 100, 257\u2013282 (1976).","journal-title":"J. molec. Biol"},{"key":"BF264415a0_CR5","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1515\/bchm2.1976.357.1.435","volume":"357","author":"J Deisenhofer","year":"1976","unstructured":"Deisenhofer, J., Colman, P. M., Huber, R., Haupt, H., and Schwick, G., Hoppe-Seyler's Z. Physiol. Chem., 357, 435\u2013445 (1976).","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"BF264415a0_CR6","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1515\/bchm2.1976.357.2.1421","volume":"357","author":"J Deisenhofer","year":"1976","unstructured":"Deisenhofer, J., Colman, P. M., Epp, O., and Huber, R., Hoppe-Seyler's Z. Physiol. Chem. 357, 1421\u20131434 (1976).","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"BF264415a0_CR7","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1432-1033.1974.tb03576.x","volume":"45","author":"O Epp","year":"1974","unstructured":"Epp, O. et al., Eur. J. Biochem., 45, 513\u2013524 (1974).","journal-title":"Eur. J. Biochem."},{"key":"BF264415a0_CR8","doi-asserted-by":"crossref","unstructured":"Palm, W., and Hilschmann, N., Hoppe-Seyler's Z. Physiol. Chem., 356, 167\u2013191","DOI":"10.1515\/bchm2.1975.356.1.167"},{"key":"BF264415a0_CR9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1515\/bchm2.1974.355.2.877","volume":"355","author":"W Palm","year":"1974","unstructured":"Palm, W., Hoppe-Seyler's Z. Physiol Chem., 355, 877\u2013880 (1974); Palm, W., Hoppe-Seyler's Z. Physiol. Chem., 357, 795\u2013789 (1976); Palm, W., Hoppe-Seyler's Z. Physiol. Chem. 357, 799\u2013802 (1976).","journal-title":"Hoppe-Seyler's Z. Physiol Chem."},{"key":"BF264415a0_CR10","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.1021\/bi00693a025","volume":"14","author":"O Epp","year":"1975","unstructured":"Epp, O., Lattman, E. E., Schiffer, M., Huber, R., and Palm, W., Biochemistry, 14, 4943\u20134952 (1975).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR11","doi-asserted-by":"publisher","first-page":"4620","DOI":"10.1021\/bi00747a013","volume":"12","author":"M Schiffer","year":"1973","unstructured":"Schiffer, M., Girling, R. L., Ely, K. R., and Edmundson, A. B., Biochemistry, 12, 4620\u20134631 (1973).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR12","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1021\/bi00776a017","volume":"11","author":"AD Strosberg","year":"1972","unstructured":"Strosberg, A. D., Fraser, K. J., Margolies, M. N., and Haber, E., Biochemistry, 11, 4978\u20134985 (1972).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1042\/bj1240053Pa","volume":"124","author":"GE Connell","year":"1971","unstructured":"Connell, G. E., and Porter, R. R., Biochem. J., 124, 53P (1971).","journal-title":"Biochem. J."},{"key":"BF264415a0_CR14","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1021\/bi00709a005","volume":"13","author":"JM Kehoe","year":"1974","unstructured":"Kehoe, J. M., Bourgois, A., Capra, J. D., and Fougereau, M., Biochemistry, 13, 2499\u20132504 (1974).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR15","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1016\/S0021-9258(18)62222-7","volume":"246","author":"R Kornfeld","year":"1971","unstructured":"Kornfeld, R., Keller, J., Baenziger, J., and Kornfeld, S., J. biol. Chem., 246, 3259\u20133268 (1971).","journal-title":"J. biol. Chem."},{"key":"BF264415a0_CR16","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1146\/annurev.bi.41.070172.003325","volume":"41","author":"RD Marshall","year":"1972","unstructured":"Marshall, R. D., A. Rev. Biochem., 41, 673\u2013702 (1972).","journal-title":"A. Rev. Biochem."},{"key":"BF264415a0_CR17","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/BF00599976","volume":"57","author":"R Huber","year":"1970","unstructured":"Huber, R., Kukla, D., R\u00fchlmann, A., Epp, O., and Formanek, H., Naturwissenschaften, 57, 389\u2013392 (1970).","journal-title":"Naturwissenschaften"},{"key":"BF264415a0_CR18","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/213862a0","volume":"213","author":"G Kartha","year":"1967","unstructured":"Kartha, G., Bello, J., and Harker, D., Nature, 213, 862\u2013865 (1967).","journal-title":"Nature"},{"key":"BF264415a0_CR19","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1016\/S0021-9258(18)95874-6","volume":"242","author":"HW Wyckoff","year":"1967","unstructured":"Wyckoff, H. W. et al., J. biol. Chem., 242, 3749\u20133753 (1967).","journal-title":"J. biol. Chem."},{"key":"BF264415a0_CR20","first-page":"7159","volume":"356","author":"H Tschesche","year":"1974","unstructured":"Tschesche, H., Klauser, R., Cechov\u00e1, D., and Yan\u00e1kov\u00e1, V., Hoppe-Seyler's Z. Physiol. Chem., 356, 7159\u20137164 (1974).","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"BF264415a0_CR21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0021-9258(18)63378-2","volume":"245","author":"RL Jackson","year":"1970","unstructured":"Jackson, R. L., and Hirs, C. H. W., J. biol. Chem., 245, 637\u2013653 (1970).","journal-title":"J. biol. Chem."},{"key":"BF264415a0_CR22","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1073\/pnas.71.4.1427","volume":"71","author":"LM Amzel","year":"1974","unstructured":"Amzel, L. M., Poljak, R. J., Saul, F., Varga, J. M., and Richards, F. P., Proc. natn. Acad. Sci. U.S.A., 71, 1427\u20131430 (1974).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF264415a0_CR23","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1073\/pnas.71.11.4298","volume":"71","author":"DM Segal","year":"1974","unstructured":"Segal, D. M., Padlan, E. A., Cohen, G. H., Rudikoff, S., Potter, M., and Davies, D. R., Proc. natn. Acad. Sci. U.S.A., 71, 4298\u20134302 (1974).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF264415a0_CR24","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1021\/bi00689a005","volume":"14","author":"AB Edmundson","year":"1975","unstructured":"Edmundson, A. B., Ely, K. R., Abola, E. E., Schiffer, M., and Panagiotopoulos, N., Biochemistry, 14, 3953\u20133961 (1975).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0022-2836(74)90163-6","volume":"89","author":"R Huber","year":"1974","unstructured":"Huber, R., Kukla, D., Bode, W., Schwager, P., Bartels, K., Deisenhofer, J., and Steigemann, W., J. molec. Biol., 89, 73\u2013101 (1974).","journal-title":"J. molec. Biol."},{"key":"BF264415a0_CR26","first-page":"1505","volume":"354","author":"S Watanabe","year":"1973","unstructured":"Watanabe, S., Barnikol, H. U., Horn, J., Bertram, J., and Hilschmann, N., Hoppe-Seyler's Z. Physiol. Chem., 354, 1505\u20131509 (1973).","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"BF264415a0_CR27","first-page":"1337","volume":"356","author":"H Kratzin","year":"1975","unstructured":"Kratzin, H., Altevogt, P., Ruban, E., Kortt, A., Staroscik, K., and Hilschmann, N., Hoppe-Seyler's Z. Physiol. Chem., 356, 1337\u20131432 (1975).","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"BF264415a0_CR28","first-page":"49","volume-title":"Progress in Immunology II","author":"H Bennich","year":"1974","unstructured":"Bennich, H., and Bahr-Lindstr\u00f6m, H., Progress in Immunology II, 1 (edit. by Brent, L., and Holborow, J.), 49\u201358 (North-Holland, Amsterdam, Oxford, 1974)."},{"key":"BF264415a0_CR29","first-page":"1003","volume":"32","author":"AD Lopes","year":"1973","unstructured":"Lopes, A. D., and Steiner, L. A., Fedn Proc., 32, 1003 (1973).","journal-title":"Fedn Proc."},{"key":"BF264415a0_CR30","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0019-2791(73)90238-3","volume":"10","author":"JW Fett","year":"1973","unstructured":"Fett, J. W., Deutsch, H. W., and Smithies, O., Immunochemistry, 10, 115\u2013118 (1973).","journal-title":"Immunochemistry"},{"key":"BF264415a0_CR31","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1016\/S0021-9258(18)62192-1","volume":"246","author":"VR Sarma","year":"1971","unstructured":"Sarma, V. R., Silverton, E. W., Davies, D. R., and Terry, W. D., J. biol. Chem., 246, 3753\u20133759 (1971).","journal-title":"J. biol. Chem."},{"key":"BF264415a0_CR32","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0022-2836(67)90063-0","volume":"27","author":"RC Valentine","year":"1965","unstructured":"Valentine, R. C., and Green, N. M., J. molec. Biol., 27, 615\u2013617 (1965).","journal-title":"J. molec. Biol."},{"key":"BF264415a0_CR33","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/205147a0","volume":"205","author":"A Feinstein","year":"1965","unstructured":"Feinstein, A., and Rowe, A. J., Nature, 205, 147\u2013149 (1965).","journal-title":"Nature"},{"key":"BF264415a0_CR34","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0022-2836(70)90009-4","volume":"51","author":"J Yguerabide","year":"1970","unstructured":"Yguerabide, J., Epstein, H. F., and Stryer, L., J. molec. Biol., 51, 573\u2013590 (1970).","journal-title":"J. molec. Biol."},{"key":"BF264415a0_CR35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0021-9258(18)97638-6","volume":"240","author":"E Noelken","year":"1965","unstructured":"Noelken, E., Nelson, C. A., Buckley, C. E., and Tanford, C., J. biol. Chem., 240, 218\u2013224 (1965).","journal-title":"J. biol. Chem."},{"key":"BF264415a0_CR36","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0019-2791(71)90203-5","volume":"8","author":"RF Ashman","year":"1971","unstructured":"Ashman, R. F., Kaplan, A. P., and Metzger, H., Immunochemistry, 8, 627\u2013641 (1971).","journal-title":"Immunochemistry"},{"key":"BF264415a0_CR37","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/0019-2791(71)90204-7","volume":"8","author":"RF Ashman","year":"1971","unstructured":"Ashman, R. F., and Metzger, H., Immunochemistry, 8, 643\u2013656 (1971).","journal-title":"Immunochemistry"},{"key":"BF264415a0_CR38","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1073\/pnas.72.7.2775","volume":"72","author":"J Schlessinger","year":"1975","unstructured":"Schlessinger, J., Steinberg, T. Z., Givol, D., Hochman, J., and Pecht, I., Proc. natn. Acad. Sci. U.S.A., 72, 2775\u20132779 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF264415a0_CR39","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1021\/bi00695a014","volume":"14","author":"JC Jaton","year":"1975","unstructured":"Jaton, J. C., Huser, H., Braun, D. G., Givol, W., Pecht, I., and Schlessinger, J., Biochemistry, 14, 5312\u20135315 (1975).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR40","doi-asserted-by":"publisher","first-page":"4998","DOI":"10.1021\/bi00748a028","volume":"12","author":"I Pilz","year":"1973","unstructured":"Pilz, I., Kratky, O., Licht, A., and Sela, M., Biochemistry, 12, 4998\u20135005 (1973).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR41","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1021\/bi00677a035","volume":"14","author":"I Pilz","year":"1975","unstructured":"Pilz, I., Kratky, O., Licht, A., and Sela, M., Biochemistry, 14, 1326\u20131333 (1975).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR42","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/0014-5793(72)80062-0","volume":"19","author":"LA Tumerman","year":"1972","unstructured":"Tumerman, L. A., Nezlin, R. S., and Zagyanski, Y. A., FEBS Lett., 19, 290\u2013292 (1972).","journal-title":"FEBS Lett."},{"key":"BF264415a0_CR43","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1021\/bi00805a001","volume":"9","author":"C Warner","year":"1970","unstructured":"Warner, C., and Shumaker, V., Biochemistry, 9, 451\u2013459 (1970).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR44","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1021\/bi00818a006","volume":"9","author":"RE Cathou","year":"1970","unstructured":"Cathou, R. E., and Warner, T. C., Biochemistry, 9, 3149\u20133155 (1970).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR45","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0019-2791(71)90202-3","volume":"8","author":"KA Kelly","year":"1971","unstructured":"Kelly, K. A., Schon, A. H., and Froese, A., Immunochemistry, 8, 613\u2013625 (1971).","journal-title":"Immunochemistry"},{"key":"BF264415a0_CR46","doi-asserted-by":"publisher","first-page":"3778","DOI":"10.1021\/bi00688a009","volume":"14","author":"SA Levison","year":"1975","unstructured":"Levison, S. A., Hicks, A. N., Portmann, A. J., and Dandliker, W. B., Biochemistry, 14, 3778\u20133786 (1975).","journal-title":"Biochemistry"},{"key":"BF264415a0_CR47","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0003-9861(60)90229-0","volume":"88","author":"A Nisonoff","year":"1960","unstructured":"Nisonoff, A., Wissler, F. C., and Woernley, D. L., Archs Biochem. Biophys., 88, 241\u2013245 (1960).","journal-title":"Archs Biochem. Biophys."},{"key":"BF264415a0_CR48","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.1073\/pnas.72.12.5111","volume":"72","author":"JC Brown","year":"1975","unstructured":"Brown, J. C., and Koshland, M. E., Proc. natn. Acad. Sci. U.S.A., 72, 5111\u20135115 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF264415a0_CR49","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1101\/SQB.1972.036.01.055","volume":"26","author":"AB Edmundson","year":"1972","unstructured":"Edmundson, A. B., Schiffer, M., Wood, M. K., Hardman, K. D., Ely, K. R., and Ainsworth, C. F., Cold Spring Harb. Symp. quant. Biol., 26, 427\u2013432 (1972).","journal-title":"Cold Spring Harb. Symp. quant. Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/264415a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/264415a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/264415a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:12:22Z","timestamp":1684282342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/264415a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,12]]},"references-count":49,"journal-issue":{"issue":"5585","published-print":{"date-parts":[[1976,12]]}},"alternative-id":["BF264415a0"],"URL":"https:\/\/doi.org\/10.1038\/264415a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,12]]}}}