{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:02:43Z","timestamp":1758268963648},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"5592","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1977,1]]},"DOI":"10.1038\/265341a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T07:09:49Z","timestamp":1123052989000},"page":"341-343","source":"Crossref","is-referenced-by-count":50,"title":["Virulence and toxicity of axenic Entamoeba histolytica"],"prefix":"10.1038","volume":"265","author":[{"given":"H. J.","family":"Bos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"VAN DE GRIEND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF265341a0_CR1","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4269\/ajtmh.1954.3.621","volume":"3","author":"BP Phillips","year":"1954","unstructured":"Phillips, B. P., and Bartgis, I. L., Am. J. trop. Med. Hyg., 3, 621\u2013627 (1954).","journal-title":"Am. J. trop. Med. Hyg."},{"key":"BF265341a0_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/j.1550-7408.1972.tb03512.x","volume":"19","author":"BP Phillips","year":"1972","unstructured":"Phillips, B. P., Diamond, L. S., Bartgis, I. L., and Stuppler, S. A., J. Protozool., 19, 498\u2013499 (1972).","journal-title":"J. Protozool."},{"key":"BF265341a0_CR3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.4269\/ajtmh.1970.19.755","volume":"19","author":"M Wittner","year":"1970","unstructured":"Wittner, M., and Rosenbaum, R. M., Am. J. trop. Med. Hyg., 19, 755\u2013761 (1970).","journal-title":"Am. J. trop. Med. Hyg."},{"key":"BF265341a0_CR4","first-page":"1","volume":"40","author":"HJ Bos","year":"1973","unstructured":"Bos, H. J., Acta leidensia, 40, 1\u2013111 (1973).","journal-title":"Acta leidensia"},{"key":"BF265341a0_CR5","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2307\/3277143","volume":"54","author":"LS Diamond","year":"1968","unstructured":"Diamond, L. S., J. Parasit., 54, 1047\u20131056 (1968).","journal-title":"J. Parasit."},{"key":"BF265341a0_CR6","first-page":"275","volume":"2","author":"M Tanimoto","year":"1971","unstructured":"Tanimoto, M., Sep\u00falveda, B., V\u00e1zquez-Saavedra, J. A., and Landa, L., Arch. inv. M\u00e9d., Mex., 2, Suppl. 1, 275\u2013284 (1971).","journal-title":"Arch. inv. M\u00e9d., Mex."},{"key":"BF265341a0_CR7","first-page":"99","volume":"4","author":"LS Diamond","year":"1973","unstructured":"Diamond, L. S., Phillips, B. P., and Bartgis, I. L., Arch. inv. M\u00e9d., Mex, 4, Suppl. 1, 99\u2013104 (1973).","journal-title":"Arch. inv. M\u00e9d., Mex"},{"key":"BF265341a0_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF00382631","volume":"47","author":"HJ Bos","year":"1975","unstructured":"Bos, H. J., and Hage, A. J., Z. Parasitkde., 47, 79\u201389 (1975).","journal-title":"Z. Parasitkde."},{"key":"BF265341a0_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0005-2736(72)90032-6","volume":"255","author":"B de Kruyff","year":"1971","unstructured":"de Kruyff, B., Demel, R. A., and van Deenen, L. L. M., Biochim. biophys. Acta, 255, 331\u2013347 (1971).","journal-title":"Biochim. biophys. Acta"},{"key":"BF265341a0_CR10","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/0035-9203(59)90008-2","volume":"53","author":"R Sharma","year":"1959","unstructured":"Sharma, R., Trans. R. Soc. trop. Med. Hyg., 53, 278\u2013281 (1959).","journal-title":"Trans. R. Soc. trop. Med. Hyg."},{"key":"BF265341a0_CR11","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/0035-9203(60)90080-8","volume":"54","author":"RA Neal","year":"1960","unstructured":"Neal, R. A., and Stewart, A. Trans. R. Soc. trop. Med. Hyg., 54, 282\u2013283 (1960).","journal-title":"Trans. R. Soc. trop. Med. Hyg."},{"key":"BF265341a0_CR12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/00034983.1964.11686259","volume":"58","author":"R Jarumilinta","year":"1964","unstructured":"Jarumilinta, R., and Kradolfer, F., Ann. trop. Med. Hyg., 58, 375\u2013381 (1964).","journal-title":"Ann. trop. Med. Hyg."},{"key":"BF265341a0_CR13","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/0035-9203(69)90191-6","volume":"63","author":"RDP Eaton","year":"1969","unstructured":"Eaton, R. D. P., Meerovitch, E., and Costerton, J. W. Trans. R. Soc. trop. Med. Hyg., 63, 678\u2013680 (1969).","journal-title":"Trans. R. Soc. trop. Med. Hyg."},{"key":"BF265341a0_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/newbio245186a0","volume":"245","author":"A Martinez-Palomo","year":"1973","unstructured":"Martinez-Palomo, A., Gonzalez-Robles, A., and de la Torre, M., Nature new Biol., 245, 186\u2013187 (1973).","journal-title":"Nature new Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/265341a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/265341a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/265341a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:16:28Z","timestamp":1684282588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/265341a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":14,"journal-issue":{"issue":"5592","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["BF265341a0"],"URL":"https:\/\/doi.org\/10.1038\/265341a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,1]]}}}