{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:48:18Z","timestamp":1790362098053,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5596","license":[{"start":{"date-parts":[[1977,2,1]],"date-time":"1977-02-01T00:00:00Z","timestamp":223603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1977,2]]},"DOI":"10.1038\/265750a0","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T21:29:29Z","timestamp":1123104569000},"page":"750-751","source":"Crossref","is-referenced-by-count":349,"title":["Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens"],"prefix":"10.1038","volume":"265","author":[{"given":"KLAUS-DIETER","family":"SCHULTZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARIN","family":"SCHULTZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00dcNTER","family":"SCHULTZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF265750a0_CR1","first-page":"249","volume":"22","author":"AP Somlyo","year":"1970","unstructured":"Somlyo, A. P. & Somlyo, A. V. Pharmacol. Rev. 22, 249\u2013353 (1970).","journal-title":"Pharmacol. Rev."},{"key":"BF265750a0_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev.pa.11.040171.001511","volume":"11","author":"L Hurwitz","year":"1971","unstructured":"Hurwitz, L. & Suria, A. A. Rev. Pharmacol. 11, 303\u2013326 (1971).","journal-title":"A. Rev. Pharmacol."},{"key":"BF265750a0_CR3","first-page":"195","volume":"4","author":"HP B\u00e4r","year":"1974","unstructured":"B\u00e4r, H. P. Adv. Cycl. Nucl. Res. 4, 195\u2013237 (1974).","journal-title":"Adv. Cycl. Nucl. Res."},{"key":"BF265750a0_CR4","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/978-1-4613-4322-6_34","volume-title":"Eukaryotic Cell Function and Growth","author":"G Schultz","year":"1976","unstructured":"Schultz, G. & Hardman, J. G. in Eukaryotic Cell Function and Growth (eds Dumont, J. E., Brown, B. L. & Marshall, N. J.) 667\u2013683 (Plenum, New York, 1976)."},{"key":"BF265750a0_CR5","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1073\/pnas.69.11.3287","volume":"69","author":"T-P Lee","year":"1972","unstructured":"Lee, T.-P., Kuo, J. F. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 3287\u20133291 (1972).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF265750a0_CR6","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1073\/pnas.71.3.815","volume":"71","author":"EW Dunham","year":"1974","unstructured":"Dunham, E. W., Haddox, M. K. & Goldberg, N. D. Proc. natn. Acad. Sci. U.S.A. 71, 815\u2013819 (1974).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF265750a0_CR7","first-page":"491","volume":"5","author":"R Andersson","year":"1975","unstructured":"Andersson, R. et al. Adv. Cycl. Nucl. Res. 5, 491\u2013518 (1975).","journal-title":"Adv. Cycl. Nucl. Res."},{"key":"BF265750a0_CR8","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1073\/pnas.70.12.3889","volume":"70","author":"G Schultz","year":"1973","unstructured":"Schultz, G., Hardman, J. G., Schultz, K., Baird, C. E. & Sutherland, E. W. Proc. natn. Acad. Sci. U.S.A. 70, 3889\u20133893 (1973).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF265750a0_CR9","first-page":"339","volume":"5","author":"G Schultz","year":"1975","unstructured":"Schultz, G. & Hardman, J. G. Adv. Cycl. Nucl. Res. 5, 339\u2013351 (1975).","journal-title":"Adv. Cycl. Nucl. Res."},{"key":"BF265750a0_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/0026-0495(75)90122-5","volume":"24","author":"G Schultz","year":"1975","unstructured":"Schultz, G., Schultz, K. & Hardman, J. G. Metabolism 24, 429\u2013437 (1975).","journal-title":"Metabolism"},{"key":"BF265750a0_CR11","volume-title":"Asthma II Physiology Immunopharmacology and Treatment","author":"G Schultz","year":"1977","unstructured":"Schultz, G. in Asthma II Physiology Immunopharmacology and Treatment (eds Austen, K. F. & Lichtenstein, L. M.) (Academic, New York, 1977)."},{"key":"BF265750a0_CR12","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1139\/y74-100","volume":"52","author":"J Diamond","year":"1974","unstructured":"Diamond, J. & Hartle, D. K. Canad. J. Physiol. Pharmacol. 52, 763\u2013767 (1974).","journal-title":"Canad. J. Physiol. Pharmacol."},{"key":"BF265750a0_CR13","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1139\/y75-153","volume":"53","author":"J Diamond","year":"1975","unstructured":"Diamond, J. & Holmes, T. G. Canad. J. Physiol. Pharmacol. 53, 1099\u20131107 (1975).","journal-title":"Canad. J. Physiol. Pharmacol."},{"key":"BF265750a0_CR14","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1172\/JCI108002","volume":"55","author":"RI Clyman","year":"1975","unstructured":"Clyman, R. I., Sandler, J. A., Manganiello, V. & Vaughan, M. J. clin. Invest. 55, 1020\u20131025 (1975).","journal-title":"J. clin. Invest."},{"key":"BF265750a0_CR15","first-page":"179","volume":"2","author":"J Diamond","year":"1976","unstructured":"Diamond, J. & Hartle, D. K. J. Cycl. Nucl. Res. 2, 179\u2013188 (1976).","journal-title":"J. Cycl. Nucl. Res."},{"key":"BF265750a0_CR16","first-page":"688","volume":"12","author":"J Diamond","year":"1976","unstructured":"Diamond, J. & Blisard, K. S. Molec. Pharmacol. 12, 688\u2013692 (1976).","journal-title":"Molec. Pharmacol."},{"key":"BF265750a0_CR17","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/BF00501284","volume":"288","author":"VAW Kreye","year":"1975","unstructured":"Kreye, V. A. W., Baron, G. D., L\u00fcth, J. B. & Schmidt-Gayk, H. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 381\u2013402 (1975).","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"BF265750a0_CR18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1152\/ajplegacy.1970.218.1.12","volume":"218","author":"L Hurwitz","year":"1970","unstructured":"Hurwitz, L. & Joiner, P. D. Am. J. Physiol. 218, 12\u201319 (1970).","journal-title":"Am. J. Physiol."},{"key":"BF265750a0_CR19","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1073\/pnas.70.6.1721","volume":"70","author":"G Schultz","year":"1973","unstructured":"Schultz, G., Hardman, J. G., Schultz, K., Davis, J. W. & Sutherland, E. W. Proc. natn. Acad. Sci. U.S.A. 70, 1721\u20131725 (1973).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF265750a0_CR20","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/257700a0","volume":"257","author":"H Kimura","year":"1975","unstructured":"Kimura, H., Mittal, C. K. & Murad, F. Nature 257, 700\u2013702 (1975).","journal-title":"Nature"},{"key":"BF265750a0_CR21","first-page":"220","volume":"18","author":"S Katsuki","year":"1976","unstructured":"Katsuki, S. & Murad, F. Pharmacologist 18, 220, (1976).","journal-title":"Pharmacologist"},{"key":"BF265750a0_CR22","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1126\/science.7837","volume":"193","author":"FR De Rubertis","year":"1976","unstructured":"De Rubertis, F. R. & Craven, P. A. Science 193, 897\u2013899 (1976).","journal-title":"Science"},{"key":"BF265750a0_CR23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/BF00507348","volume":"293","author":"G P\u00f6ch","year":"1976","unstructured":"P\u00f6ch, G. & Umfahrer, W. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 257\u2013268 (1976).","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"BF265750a0_CR24","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/BF01494064","volume":"49","author":"A Fleckenstein","year":"1971","unstructured":"Fleckenstein, A., Gr\u00fcn, G., Tritthart, H., Byon, K. & Harding, P. Klin. Wschr. 49, 32\u201341 (1971).","journal-title":"Klin. Wschr."},{"key":"BF265750a0_CR25","first-page":"334","volume":"22","author":"G Gr\u00fcn","year":"1972","unstructured":"Gr\u00fcn, G. & Fleckenstein, A. Arzneim.-Forsch. 22, 334\u2013344 (1972).","journal-title":"Arzneim.-Forsch."},{"key":"BF265750a0_CR26","first-page":"35","volume":"196","author":"T Godfraind","year":"1972","unstructured":"Godfraind, T. & Kaba, A. Arch. int. Pharmacodyn. Suppl. 196, 35\u201349 (1972).","journal-title":"Arch. int. Pharmacodyn. Suppl."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/265750a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/265750a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/265750a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:19:08Z","timestamp":1684282748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/265750a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2]]},"references-count":26,"journal-issue":{"issue":"5596","published-print":{"date-parts":[[1977,2]]}},"alternative-id":["BF265750a0"],"URL":"https:\/\/doi.org\/10.1038\/265750a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,2]]}}}