{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:18:51Z","timestamp":1760980731548},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5664","license":[{"start":{"date-parts":[[1978,6,1]],"date-time":"1978-06-01T00:00:00Z","timestamp":265507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1978,6]]},"DOI":"10.1038\/273640a0","type":"journal-article","created":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T15:22:35Z","timestamp":1122996155000},"page":"640-643","source":"Crossref","is-referenced-by-count":46,"title":["Isolation and partial sequence of recombinant plasmids containing human \u03b1-, \u03b2- and \u03b3-globin cDNA fragments"],"prefix":"10.1038","volume":"273","author":[{"given":"P.","family":"Little","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch.","family":"Coutelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dalgleish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Malcolm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Courtney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Westaway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF273640a0_CR1","volume-title":"The Thalassaemia Syndromes","author":"DJ Weatherall","year":"1972","unstructured":"Weatherall, D. J. & Clegg, J. B. The Thalassaemia Syndromes, 2nd edn (Blackwell, Oxford, 1972)."},{"key":"BF273640a0_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1093\/oxfordjournals.bmb.a071376","volume":"32","author":"WG Wood","year":"1976","unstructured":"Wood, W. G. Br. med. Bull. 32, 282\u2013287 (1976).","journal-title":"Br. med. Bull."},{"key":"BF273640a0_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0140-6736(74)91558-X","volume":"ii","author":"JB Clegg","year":"1974","unstructured":"Clegg, J. B. & Weatherall, D. J. Lancet ii, 133\u2013135 (1974).","journal-title":"Lancet"},{"key":"BF273640a0_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0092-8674(76)90053-2","volume":"9","author":"S Ottolenghi","year":"1976","unstructured":"Ottolenghi, S. et al. Cell 9, 71\u201380 (1976).","journal-title":"Cell"},{"key":"BF273640a0_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/259095a0","volume":"259","author":"P Tolstoshev","year":"1976","unstructured":"Tolstoshev, P. et al. Nature 259, 95\u201398 (1976).","journal-title":"Nature"},{"key":"BF273640a0_CR6","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1432-1033.1977.tb11846.x","volume":"79","author":"P Comi","year":"1977","unstructured":"Comi, P. et al. Eur. J. Biochem. 79, 617\u2013622 (1977).","journal-title":"Eur. J. Biochem."},{"key":"BF273640a0_CR7","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.1073\/pnas.72.12.5140","volume":"72","author":"YW Kan","year":"1975","unstructured":"Kan, Y. W., Holland, J. P., Dozy, A. M. & Varmus, H. E. Proc. natn. Acad. Sci. U.S.A. 72, 5140\u20135144 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF273640a0_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/254256a0","volume":"254","author":"F Conconi","year":"1975","unstructured":"Conconi, F. et al. Nature 254, 256\u2013259 (1975).","journal-title":"Nature"},{"key":"BF273640a0_CR9","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev.ge.10.120176.001105","volume":"10","author":"DJ Weatherall","year":"1976","unstructured":"Weatherall, D. J. & Clegg, J. B. A. Rev. Genet. 10, 157\u2013178 (1976).","journal-title":"A. Rev. Genet."},{"key":"BF273640a0_CR10","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1016\/S0021-9258(19)45186-7","volume":"247","author":"HF Lodish","year":"1972","unstructured":"Lodish, H. F. & Jacobson, M. J. biol. Chem. 247, 3622\u20133629 (1972).","journal-title":"J. biol. Chem."},{"key":"BF273640a0_CR11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/251389a0","volume":"251","author":"S Ottolenghi","year":"1974","unstructured":"Ottolenghi, S. et al. Nature 251, 389\u2013392 (1974).","journal-title":"Nature"},{"key":"BF273640a0_CR12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/255255a0","volume":"255","author":"YW Kan","year":"1975","unstructured":"Kan, Y. W. et al. Nature 255, 255\u2013256 (1975).","journal-title":"Nature"},{"key":"BF273640a0_CR13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1126\/science.322277","volume":"196","author":"KA Armstrong","year":"1977","unstructured":"Armstrong, K. A., Hershfield, V. & Helinski, D. R. Science 196, 172\u2013174 (1977).","journal-title":"Science"},{"key":"BF273640a0_CR14","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1073\/pnas.72.10.3961","volume":"72","author":"M Grunstein","year":"1975","unstructured":"Grunstein, M. & Hogness, D. S. Proc. natn. Acad. Sci. U.S.A. 72, 3961\u20133965 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF273640a0_CR15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0092-8674(76)90088-X","volume":"9","author":"N Maizels","year":"1976","unstructured":"Maizels, N. Cell 9, 431\u2013438 (1976).","journal-title":"Cell"},{"key":"BF273640a0_CR16","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1073\/pnas.72.6.2294","volume":"72","author":"S Ottolenghi","year":"1975","unstructured":"Ottolenghi, S. et al. Proc. natn. Acad. Sci. U.S.A. 72, 2294\u20132299 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF273640a0_CR17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/260221a0","volume":"260","author":"TH Rabbitts","year":"1976","unstructured":"Rabbitts, T. H. Nature 260, 221\u2013224 (1976).","journal-title":"Nature"},{"key":"BF273640a0_CR18","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1093\/nar\/2.12.2365","volume":"2","author":"F Rougeon","year":"1975","unstructured":"Rougeon, F., Kourilsky, P. & Mach, B. Nucleic Acid Res. 2, 2365\u20132378 (1975).","journal-title":"Nucleic Acid Res."},{"key":"BF273640a0_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0092-8674(76)90027-1","volume":"7","author":"A Efstratiadis","year":"1976","unstructured":"Efstratiadis, A., Kafatos, F. C., Maxam, A. M. & Maniatis, T. Cell 7, 279\u2013288 (1976).","journal-title":"Cell"},{"key":"BF273640a0_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0092-8674(76)90001-5","volume":"8","author":"T Maniatis","year":"1976","unstructured":"Maniatis, T., Kee, S. G., Efstratiadis, A. & Kafatos, F. C. Cell 8, 163\u2013182 (1976).","journal-title":"Cell"},{"key":"BF273640a0_CR21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1126\/science.847468","volume":"196","author":"JT Wilson","year":"1977","unstructured":"Wilson, J. T., Forget, B. G., Wilson, C. B. & Weissman, S. M. Science 196, 200\u2013202 (1977).","journal-title":"Science"},{"key":"BF273640a0_CR22","volume-title":"Report of the Working Party on the Practice of Genetic Manipulation","author":"REO Williams","year":"1976","unstructured":"Williams, R. E. O. Report of the Working Party on the Practice of Genetic Manipulation (HMSO, London, 1976)."},{"key":"BF273640a0_CR23","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/oxfordjournals.bmb.a071370","volume":"32","author":"R Williamson","year":"1976","unstructured":"Williamson, R. Br. med. Bull. 32, 246\u2013250 (1976).","journal-title":"Br. med. Bull."},{"key":"BF273640a0_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0092-8674(76)90180-X","volume":"8","author":"J Old","year":"1976","unstructured":"Old, J. et al. Cell 8, 13\u201328 (1976).","journal-title":"Cell"},{"key":"BF273640a0_CR25","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1016\/S0021-9258(17)40543-6","volume":"252","author":"F Rougeon","year":"1976","unstructured":"Rougeon, F. & Mach, B. J. biol. Chem. 252, 2209\u20132217 (1976).","journal-title":"J. biol. Chem."},{"key":"BF273640a0_CR26","doi-asserted-by":"crossref","unstructured":"Roberts, R. J. CRC Critical Rev. Biochem., 123\u2013164 (1976).","DOI":"10.3109\/10409237609105456"},{"key":"BF273640a0_CR27","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1016\/S0021-9258(17)40156-6","volume":"252","author":"CA Marotta","year":"1977","unstructured":"Marotta, C. A., Wilson, J. T., Forget, B. G. & Weissman, S. M. J. biol. Chem. 252, 5040\u20135053 (1977).","journal-title":"J. biol. Chem."},{"key":"BF273640a0_CR28","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/0005-2787(76)90286-0","volume":"454","author":"H Hofstetter","year":"1976","unstructured":"Hofstetter, H., Schambock, A., Van Den Berg, J. & Weissmann, C. Biochim. biophys. Acta 454, 587\u2013591 (1976).","journal-title":"Biochim. biophys. Acta"},{"key":"BF273640a0_CR29","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/0022-2836(74)90115-6","volume":"84","author":"PR Harrison","year":"1974","unstructured":"Harrison, P. R., Birnie, G. D., Hell, A., Humphries, S., Young, B. D. & Paul, J. J. molec. Biol. 84, 539\u2013554 (1974).","journal-title":"J. molec. Biol."},{"key":"BF273640a0_CR30","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1093\/nar\/3.8.2019","volume":"3","author":"JF Jackson","year":"1976","unstructured":"Jackson, J. F., Tolstoshev, P., Williamson, R. & Hendrick, D. Nucleic Acid Res. 3, 2019\u20132026 (1976).","journal-title":"Nucleic Acid Res."},{"key":"BF273640a0_CR31","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0014-5793(77)80609-1","volume":"82","author":"RA Laskey","year":"1977","unstructured":"Laskey, R. A. & Mills, A. D. FEBS Lett. 82, 314\u2013316 (1977).","journal-title":"FEBS Lett."},{"key":"BF273640a0_CR32","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1073\/pnas.74.2.560","volume":"74","author":"AM Maxam","year":"1977","unstructured":"Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560\u2013564 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF273640a0_CR33","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1073\/pnas.60.2.537","volume":"60","author":"WA Schroeder","year":"1968","unstructured":"Schroeder, W. A. et al. Proc. natn. Acad. Sci. U.S.A. 60, 537\u2013544 (1968).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF273640a0_CR34","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","volume":"98","author":"EM Southern","year":"1975","unstructured":"Southern, E. M. J. molec. Biol. 98, 503\u2013517 (1975).","journal-title":"J. molec. Biol."},{"key":"BF273640a0_CR35","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/nar\/5.2.563","volume":"5","author":"JT Wilson","year":"1978","unstructured":"Wilson, J. T. et al. Nucleic Acid Res. 5, 563\u2013581 (1978).","journal-title":"Nucleic Acid Res."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/273640a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/273640a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/273640a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:18:47Z","timestamp":1684282727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/273640a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":35,"journal-issue":{"issue":"5664","published-print":{"date-parts":[[1978,6]]}},"alternative-id":["BF273640a0"],"URL":"https:\/\/doi.org\/10.1038\/273640a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}