{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:18:50Z","timestamp":1760980730266},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5706","license":[{"start":{"date-parts":[[1979,4,1]],"date-time":"1979-04-01T00:00:00Z","timestamp":291772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1979,4]]},"DOI":"10.1038\/278745a0","type":"journal-article","created":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T12:29:38Z","timestamp":1122985778000},"page":"745-748","source":"Crossref","is-referenced-by-count":91,"title":["Direct linkage of epidermal growth factor to its receptor"],"prefix":"10.1038","volume":"278","author":[{"given":"PETER S.","family":"LINSLEY","sequence":"first","affiliation":[]},{"given":"CINDY","family":"BLIFELD","sequence":"additional","affiliation":[]},{"given":"MICHAEL","family":"WRANN","sequence":"additional","affiliation":[]},{"given":"C. FRED","family":"Fox","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[1979,4,1]]},"reference":[{"key":"BF278745a0_CR1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0021-9258(17)38184-X","volume":"253","author":"I Diamond","year":"1978","unstructured":"Diamond, I., Legg, A., Schneider, J. A. & Rosengurt, E. J. biol. Chem. 253, 866\u2013871 (1978).","journal-title":"J. biol. Chem."},{"key":"BF278745a0_CR2","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1073\/pnas.74.11.5046","volume":"74","author":"RW Holley","year":"1977","unstructured":"Holley, R. W., Armour, R., Baldwin, J. H., Brown, K. D. & Yeh, Y.-C. Proc. natn. Acad. Sci. U.S.A. 74, 5046\u20135050 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR3","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1016\/S0021-9258(17)34785-3","volume":"253","author":"A Aharonov","year":"1978","unstructured":"Aharonov, A., Pruss, R. M. & Herschman, H. R. J. biol. Chem. 253, 3970\u20133977 (1978).","journal-title":"J. biol. Chem."},{"key":"BF278745a0_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1083\/jcb.71.1.159","volume":"71","author":"G Carpenter","year":"1976","unstructured":"Carpenter, G. & Cohen, S. J. Cell Biol. 71, 159\u2013171 (1976).","journal-title":"J. Cell Biol."},{"key":"BF278745a0_CR5","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1073\/pnas.75.7.3317","volume":"75","author":"H Haigler","year":"1978","unstructured":"Haigler, H., Ash, J. F., Singer, S. J. & Cohen, S. Proc. natn. Acad. Sci. U.S.A. 75, 3317\u20133321 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR6","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1073\/pnas.75.6.2659","volume":"75","author":"J Schlessinger","year":"1978","unstructured":"Schlessinger, J., Schechter, Y., Willingham, M. C. & Pastan, I. Proc. natn. Acad. Sci. U.S.A. 75, 2659\u20132663 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR7","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1073\/pnas.74.7.2790","volume":"74","author":"M Das","year":"1977","unstructured":"Das, M. et al. Proc. natn. Acad. Sci. U.S.A. 74, 2790\u20132794 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR8","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1073\/pnas.75.6.2644","volume":"75","author":"M Das","year":"1978","unstructured":"Das, M. & Fox, C. F. Proc. natn. Acad. Sci. U.S.A. 75, 2644\u20132648 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR9","first-page":"131","volume-title":"Membranes and Disease","author":"A Trouet","year":"1976","unstructured":"Trouet, A. & Tulkens, P. in Membranes and Disease (eds Bollis, L., Hoffman, J. F. & Leaf, A.) 131\u2013144 (Raven, New York, 1976)."},{"key":"BF278745a0_CR10","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1021\/bi00606a022","volume":"17","author":"GE Siefring","year":"1978","unstructured":"Siefring, G. E., Apostol, A. B., Velasco, P. T. & Lorand, L. Biochemistry 17, 2598\u20132604 (1978).","journal-title":"Biochemistry"},{"key":"BF278745a0_CR11","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"277","author":"VK Laemmli","year":"1970","unstructured":"Laemmli, V. K. Nature 277, 680\u2013685 (1970).","journal-title":"Nature"},{"key":"BF278745a0_CR12","first-page":"321","volume-title":"Methods in Immunology and Immunochemistry","author":"JL Fahey","year":"1967","unstructured":"Fahey, J. L. in Methods in Immunology and Immunochemistry (ed. Williams, C.) 321\u2013322 (Academic, New York, 1967)."},{"key":"BF278745a0_CR13","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1210\/endo-90-5-1261","volume":"90","author":"RL Bygny","year":"1972","unstructured":"Bygny, R. L., Orth, O. N. & Cohen, S. Endocrinology 90, 1261\u20131266 (1972).","journal-title":"Endocrinology"},{"key":"BF278745a0_CR14","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.115.6.1617","volume":"115","author":"SW Kessler","year":"1975","unstructured":"Kessler, S. W. J. Immun. 115, 1617\u20131624 (1975).","journal-title":"J. Immun."},{"key":"BF278745a0_CR15","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","volume":"51","author":"G Scatchard","year":"1949","unstructured":"Scatchard, G. Ann N.Y. Acad. Sci. 51, 660\u2013672 (1949).","journal-title":"Ann N.Y. Acad. Sci."},{"key":"BF278745a0_CR16","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1073\/pnas.70.11.3195","volume":"70","author":"SD Schimmel","year":"1973","unstructured":"Schimmel, S. D., Kent, C., Bischoff, R. & Vagelos, P. R. Proc. natn. Acad. Sci. U.S.A. 70, 3195\u20133199 (1973).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR17","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1073\/pnas.71.9.3537","volume":"71","author":"H Heitzman","year":"1974","unstructured":"Heitzman, H. & Richards, F. M. Proc. natn. Acad. Sci. U.S.A. 71, 3537\u20133541 (1974).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR18","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1073\/pnas.74.2.565","volume":"74","author":"RN Fabricant","year":"1977","unstructured":"Fabricant, R. N., DeLarco, J. E. & Todaro, G. J. Proc. natn. Acad. Sci. U.S.A. 74, 565\u2013569 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF278745a0_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/278743a0","volume":"278","author":"JB Baker","year":"1979","unstructured":"Baker, J. B., Simmer, R. L., Glenn, K. C. & Cunningham, D. D. Nature 278, 743\u2013745 (1979).","journal-title":"Nature"},{"key":"BF278745a0_CR20","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1016\/S0021-9258(17)34631-8","volume":"253","author":"CR Kahn","year":"1978","unstructured":"Kahn, C. R. & Baird, K. J. biol. Chem. 253, 4900\u20134906 (1978).","journal-title":"J. biol. Chem."},{"key":"BF278745a0_CR21","doi-asserted-by":"crossref","unstructured":"Green, H. & Kehinke, O. Cell 13 19\u201337.","DOI":"10.1017\/S0084255900010342"},{"key":"BF278745a0_CR22","doi-asserted-by":"publisher","first-page":"5788","DOI":"10.1073\/pnas.75.12.5788","volume":"75","author":"Y Schechter","year":"1978","unstructured":"Schechter, Y., Hernaez, L. & Cuatrecasas, P. Proc. natn. Acad. Sci. U.S.A. 75, 5788\u20135791 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/278745a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/278745a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/278745a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:02:02Z","timestamp":1684281722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/278745a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4]]},"references-count":22,"journal-issue":{"issue":"5706","published-print":{"date-parts":[[1979,4]]}},"alternative-id":["BF278745a0"],"URL":"https:\/\/doi.org\/10.1038\/278745a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4]]}}}