{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:11:50Z","timestamp":1771866710133,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5806","license":[{"start":{"date-parts":[[1981,4,1]],"date-time":"1981-04-01T00:00:00Z","timestamp":354931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1981,4]]},"DOI":"10.1038\/290505a0","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T19:09:22Z","timestamp":1100718562000},"page":"505-508","source":"Crossref","is-referenced-by-count":156,"title":["Fibrinolysis with acyl-enzymes: a new approach to thrombolytic therapy"],"prefix":"10.1038","volume":"290","author":[{"given":"R. A. G.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Dupe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"English","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF290505a0_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S0076-6879(76)45009-7","volume":"45","author":"JH Griffin","year":"1976","unstructured":"Griffin, J. H. et al. Meth. Enzym. 45, 56\u2013177 (1976).","journal-title":"Meth. Enzym."},{"key":"BF290505a0_CR2","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1021\/ja00872a019","volume":"84","author":"ML Bender","year":"1962","unstructured":"Bender, M. L. & Zerner, B. J. Am. chem. Soc. 84, 2550\u20132555 (1962).","journal-title":"J. Am. chem. Soc."},{"key":"BF290505a0_CR3","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/0006-291X(67)90513-X","volume":"29","author":"T Chase Jr","year":"1967","unstructured":"Chase, T. Jr & Shaw, E. Biochem. biophys. Res. Commun. 29, 508\u2013514 (1967).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF290505a0_CR4","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1021\/bi00833a063","volume":"8","author":"T Chase Jr","year":"1969","unstructured":"Chase, T. Jr & Shaw, E. Biochemistry 8, 2212\u20132224 (1969).","journal-title":"Biochemistry"},{"key":"BF290505a0_CR5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1021\/jm00261a022","volume":"16","author":"G Glover","year":"1973","unstructured":"Glover, G., Wang, C.-C. & Shaw, E. J. med. Chem. 16, 262\u2013267 (1973).","journal-title":"J. med. Chem."},{"key":"BF290505a0_CR6","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1016\/S0021-9258(17)33045-4","volume":"251","author":"M Moroi","year":"1976","unstructured":"Moroi, M. & Aoki, N. J. biol. Chem. 251, 5956\u20135965 (1976).","journal-title":"J. biol. Chem."},{"key":"BF290505a0_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1042\/bj1590545","volume":"159","author":"S Mullertz","year":"1976","unstructured":"Mullertz, S. & Clemmensen, I. Biochem. J. 159, 545\u2013553 (1976).","journal-title":"Biochem. J."},{"key":"BF290505a0_CR8","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1042\/bj1330709","volume":"133","author":"AJ Barrett","year":"1973","unstructured":"Barrett, A. J. & Starkey, P. M. Biochem. J. 133, 709\u2013724 (1973).","journal-title":"Biochem. J."},{"key":"BF290505a0_CR9","first-page":"191","volume-title":"Progress in Chemical Fibrinoly sis and Thrombolysis","author":"L Sottrup-Jensen","year":"1978","unstructured":"Sottrup-Jensen, L. et al. in Progress in Chemical Fibrinoly sis and Thrombolysis Vol. 3 (eds Davidson, J. F. et al.) 191\u2013209 (Raven, New York, 1978)."},{"key":"BF290505a0_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.1432-1033.1978.tb12200.x","volume":"84","author":"B Wiman","year":"1978","unstructured":"Wiman, B. & Collen, D. Eur. J. Biochem. 84, 573\u2013578 (1978).","journal-title":"Eur. J. Biochem."},{"key":"BF290505a0_CR11","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/272549a0","volume":"272","author":"B Wiman","year":"1978","unstructured":"Wiman, B. & Collen, D. Nature 272, 549\u2013550 (1978).","journal-title":"Nature"},{"key":"BF290505a0_CR12","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2165\/00003495-197305050-00002","volume":"5","author":"RN Brogden","year":"1973","unstructured":"Brogden, R. N., Speight, T. M. & Avery, G. S. Drugs 5, 357\u2013445 (1973).","journal-title":"Drugs"},{"key":"BF290505a0_CR13","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1021\/ja00455a046","volume":"99","author":"K Tanizawa","year":"1977","unstructured":"Tanizawa, K., Kasaba, Y. & Kanaoka, Y. J. Am. chem. Soc. 99, 4495\u20134499 (1977).","journal-title":"J. Am. chem. Soc."},{"key":"BF290505a0_CR14","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/0006-291X(71)90670-X","volume":"43","author":"DK McClintock","year":"1971","unstructured":"McClintock, D. K. & Bell, P. H. Biochem. biophys. Res. Commun. 43, 694\u2013702 (1971).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF290505a0_CR15","unstructured":"Smith, R. A. G. Eur. Patent Applic. No. 9879 (1980)."},{"key":"BF290505a0_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0049-3848(73)90025-X","volume":"2","author":"DK Heene","year":"1973","unstructured":"Heene, D. K. & Matthias, F. R. Thromb. Res. 2, 137\u2013154 (1973).","journal-title":"Thromb. Res."},{"key":"BF290505a0_CR17","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1126\/science.170.3962.1095","volume":"170","author":"DD Deutsch","year":"1970","unstructured":"Deutsch, D. D. & Mertz, E. T. Science 170, 1095\u20131096 (1970).","journal-title":"Science"},{"key":"BF290505a0_CR18","first-page":"145","volume-title":"The Physiological Inhibitors of Coagulation and Fibrinolysis","author":"B Wiman","year":"1979","unstructured":"Wiman, B. & Collen, D. in The Physiological Inhibitors of Coagulation and Fibrinolysis (eds Collen, D. et al.) 145\u2013146 (Elsevier, Amsterdam, 1979)."},{"key":"BF290505a0_CR19","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1021\/bi00669a025","volume":"15","author":"E Mihalyi","year":"1976","unstructured":"Mihalyi, E. et al. Biochemistry 15, 5372\u20135381 (1976).","journal-title":"Biochemistry"},{"key":"BF290505a0_CR20","first-page":"121","volume-title":"Chromogenic Peptide Substrates","author":"G Friberger","year":"1979","unstructured":"Friberger, G. et al. in Chromogenic Peptide Substrates (eds Scully, M. F. & Kakkar, V. V.) 121\u2013127 (Churchill-Livingstone, Edinburgh, 1979)."},{"key":"BF290505a0_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-3-642-66863-0_6","volume-title":"Fibrinolytics and Antifibrinolytics","author":"H-P Kl\u00f6cking","year":"1978","unstructured":"Kl\u00f6cking, H.-P. in Fibrinolytics and Antifibrinolytics (ed. Markwardt, F.) 151\u2013153 (Springer, Berlin, 1978)."},{"key":"BF290505a0_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1055\/s-0038-1654323","volume":"25","author":"AJ Baillie","year":"1971","unstructured":"Baillie, A. J. & Sim, A. K. Throm. Diath. haemorrh. 25, 499\u2013506 (1971).","journal-title":"Throm. Diath. haemorrh."},{"key":"BF290505a0_CR23","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1136\/bmj.2.6044.1100","volume":"2","author":"CP Aber","year":"1976","unstructured":"Aber, C. P. et al. Br. med. J. 2, 1100\u20131104 (1976).","journal-title":"Br. med. J."},{"key":"BF290505a0_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/jcp.23.1.43","volume":"23","author":"HBC Burmester","year":"1970","unstructured":"Burmester, H. B. C. et al. J. clin. Path. 23, 43\u201346 (1970).","journal-title":"J. clin. Path."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/290505a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/290505a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/290505a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:19:16Z","timestamp":1684282756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/290505a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":24,"journal-issue":{"issue":"5806","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["BF290505a0"],"URL":"https:\/\/doi.org\/10.1038\/290505a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}