{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:20:24Z","timestamp":1768083624233,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5885","license":[{"start":{"date-parts":[[1982,10,1]],"date-time":"1982-10-01T00:00:00Z","timestamp":402278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1982,10]]},"DOI":"10.1038\/299756a0","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T22:03:50Z","timestamp":1100729030000},"page":"756-758","source":"Crossref","is-referenced-by-count":271,"title":["Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding"],"prefix":"10.1038","volume":"299","author":[{"given":"Greg","family":"Winter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Fersht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Zoller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"BF299756a0_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0079-6603(08)60660-1","volume":"12","author":"RB Loftfield","year":"1972","unstructured":"Loftfield, R. B. Prog. Nucleic Acids Res. 12, 87\u2013128 (1972).","journal-title":"Prog. Nucleic Acids Res."},{"key":"BF299756a0_CR2","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1021\/bi00686a010","volume":"14","author":"AR Fersht","year":"1975","unstructured":"Fersht, A. R. & Jakes, R. Biochemistry 14, 3350\u20133356 (1975).","journal-title":"Biochemistry"},{"key":"BF299756a0_CR3","unstructured":"Winter, G., Hartley, B. S., Koch, G. L. E. & Barker, D. G. (in preparation)."},{"key":"BF299756a0_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1432-1033.1982.tb06691.x","volume":"125","author":"G Barker","year":"1982","unstructured":"Barker, G. Eur. J. Biochem. 125, 357\u2013360 (1982).","journal-title":"Eur. J. Biochem."},{"key":"BF299756a0_CR5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/0022-2836(82)90255-8","volume":"158","author":"TN Bhat","year":"1982","unstructured":"Bhat, T. N., Blow, D. M., Brick, P. & Nyborg, J. J. molec. Biol. 158, 699\u2013709 (1982).","journal-title":"J. molec. Biol."},{"key":"BF299756a0_CR6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0022-2836(78)90418-7","volume":"122","author":"C Monteilhet","year":"1978","unstructured":"Monteilhet, C. & Blow, D. M. J. molec. Biol. 122, 407\u2013417 (1978).","journal-title":"J. molec. Biol."},{"key":"BF299756a0_CR7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0022-2836(81)90541-6","volume":"145","author":"J Rubin","year":"1981","unstructured":"Rubin, J. & Blow, D. M. J. molec. Biol. 145, 489\u2013500 (1981).","journal-title":"J. molec. Biol."},{"key":"BF299756a0_CR8","first-page":"255","volume-title":"Transfer RNA: Structure Properties and Recognition","author":"GP Winter","year":"1979","unstructured":"Winter, G. P., Koch, G. L. E., Dell, A. & Hartley, B. S. in Transfer RNA: Structure Properties and Recognition (eds Schimmel, P. R., Soll, D. & Abelson, J. N.) 255\u2013265 (Cold Spring Harbor Laboratory, New York, 1979)."},{"key":"BF299756a0_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0014-5793(82)80165-8","volume":"145","author":"DG Barker","year":"1982","unstructured":"Barker, D. G. & Winter, G. FEBS Lett. 145, 191\u2013193 (1982).","journal-title":"FEBS Lett."},{"key":"BF299756a0_CR10","unstructured":"Zoller, M. & Smith, M. Meth. Enzym. (in the press)."},{"key":"BF299756a0_CR11","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1016\/S0021-9258(19)46967-6","volume":"253","author":"CA Hutchison III","year":"1978","unstructured":"Hutchison, C. A. III et al. J. biol. Chem. 253, 6551\u20136560 (1978).","journal-title":"J. biol. Chem."},{"key":"BF299756a0_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4615-7075-2_1","volume-title":"Genetic Engineering","author":"M Smith","year":"1981","unstructured":"Smith, M. & Gillam, S. in Genetic Engineering Vol. 3 (eds Setlow, J. K. & Hollaender, A.) 1 (Plenum, New York, 1981)."},{"key":"BF299756a0_CR13","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1073\/pnas.77.12.7024","volume":"77","author":"B Wasylyk","year":"1980","unstructured":"Wasylyk, B. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7024\u20137028 (1980).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF299756a0_CR14","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0378-1119(82)90070-1","volume":"17","author":"CG Miyada","year":"1982","unstructured":"Miyada, C. G., Soberon, X., Itakura, K. & Wilcox, G. Gene 17, 167\u2013177 (1982).","journal-title":"Gene"},{"key":"BF299756a0_CR15","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/nar\/2.5.625","volume":"2","author":"S Gillam","year":"1975","unstructured":"Gillam, S., Waterman, K. & Smith, M. Nucleic Acids Res. 2, 625\u2013634 (1975).","journal-title":"Nucleic Acids Res."},{"key":"BF299756a0_CR16","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1093\/nar\/9.15.3647","volume":"9","author":"RB Wallace","year":"1981","unstructured":"Wallace, R. B., Schold, M., Johnson, M. J., Dembek, P. & Itakura, K. Nucleic Acids Res. 9, 3647\u20133657 (1981).","journal-title":"Nucleic Acids Res."},{"key":"BF299756a0_CR17","doi-asserted-by":"publisher","first-page":"6613","DOI":"10.1073\/pnas.78.11.6613","volume":"78","author":"SV Suggs","year":"1982","unstructured":"Suggs, S. V., Wallace, R. B., Hirose, T., Kawashima, E. & Itakura, K. Proc. natn. Acad. Sci. U.S.A. 78, 6613\u20136617 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF299756a0_CR18","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"F Sanger","year":"1977","unstructured":"Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463\u20135467 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF299756a0_CR19","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1128\/JB.110.3.1135-1146.1972","volume":"110","author":"DB Clewell","year":"1972","unstructured":"Clewell, D. B. & Helinski, D. R. J. Bact. 110, 1135\u20131146 (1972).","journal-title":"J. Bact."},{"key":"BF299756a0_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0022-2836(71)90090-8","volume":"56","author":"B Hohn","year":"1971","unstructured":"Hohn, B., Lechner, H. & Marvin, D. A. J. molec. Biol. 56, 143\u2013154 (1971).","journal-title":"J. molec. Biol."},{"key":"BF299756a0_CR21","unstructured":"Barker, D. G., Bruton, C. J. & Winter, G. (in preparation)."},{"key":"BF299756a0_CR22","first-page":"151","volume":"157","author":"WD McElroy","year":"1967","unstructured":"McElroy, W. D., De Luca, M. & Travis, J. Science 157, 151\u2013160 (1967).","journal-title":"Science"},{"key":"BF299756a0_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1021\/bi00672a002","volume":"14","author":"AR Fersht","year":"1975","unstructured":"Fersht, A. R. Biochemistry 14, 5\u201312 (1975).","journal-title":"Biochemistry"},{"key":"BF299756a0_CR24","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1107\/S0567740875006772","volume":"31","author":"AK Kerr","year":"1975","unstructured":"Kerr, A. K., Ashmore, J. P. & Koetzle, T. F. Acta crystallogr. B31, 2022\u20132026 (1975).","journal-title":"Acta crystallogr."},{"key":"BF299756a0_CR25","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1107\/S0567740874007618","volume":"30","author":"TJ Kistenmacher","year":"1974","unstructured":"Kistenmacher, T. J., Rand, G. A. & Marsh, R. E. Acta Crystallogr. B30, 2573\u20132578 (1974).","journal-title":"Acta Crystallogr."},{"key":"BF299756a0_CR26","first-page":"379","volume-title":"Chemistry of the \u2212SH group","author":"MR Crampton","year":"1974","unstructured":"Crampton, M. R. in Chemistry of the \u2212SH group (ed. Patai, S.) 379\u2013415 (Wiley-Inter-science, New York, 1974)."},{"key":"BF299756a0_CR27","first-page":"111","volume-title":"Chemistry of the \u2212SH group","author":"IC Paul","year":"1974","unstructured":"Paul, I. C. in Chemistry of the \u2212SH group (ed. Patai, S.) 111\u2013149 (Wiley-Interecience, New York, 1974)."},{"key":"BF299756a0_CR28","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1021\/bi00574a020","volume":"18","author":"AR Fersht","year":"1979","unstructured":"Fersht, A. R. & Dingwall, C. Biochemistry 18, 1245\u20131249 (1979).","journal-title":"Biochemistry"},{"key":"BF299756a0_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1042\/bj1050017","volume":"105","author":"RL Heinrikson","year":"1967","unstructured":"Heinrikson, R. L. & Hartley, B. S. Biochem. J. 105, 17\u201324 (1967).","journal-title":"Biochem. J."},{"key":"BF299756a0_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1101\/SQB.1979.043.01.013","volume":"43","author":"JG Sutcliffe","year":"1978","unstructured":"Sutcliffe, J. G. Cold Spring Harb. Symp. quant. Biol. 43, 77\u201390 (1978).","journal-title":"Cold Spring Harb. Symp. quant. Biol."},{"key":"BF299756a0_CR31","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/BF01114911","volume":"1","author":"GF Hong","year":"1981","unstructured":"Hong, G. F. Biosci. Rep. 1, 243\u2013252 (1981).","journal-title":"Biosci. Rep."},{"key":"BF299756a0_CR32","first-page":"43","volume":"2","author":"J Messing","year":"1979","unstructured":"Messing, J. Recombinant DNA Tech. Bull. 2, 43\u201348 (1979).","journal-title":"Recombinant DNA Tech. Bull."},{"key":"BF299756a0_CR33","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1073\/pnas.69.8.2110","volume":"69","author":"SN Cohen","year":"1972","unstructured":"Cohen, S. N., Chang, A. C. Y. & Hsu, L. Proc. natn. Acad. Sci. U.S.A. 69, 2110\u20132114 (1972).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF299756a0_CR34","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1093\/nar\/8.9.1965","volume":"8","author":"G Winter","year":"1980","unstructured":"Winter, G. & Fields, S. Nucleic Acids Res. 8, 1965\u20131974 (1980).","journal-title":"Nucleic Acids Res."},{"key":"BF299756a0_CR35","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1073\/pnas.72.10.3961","volume":"72","author":"M Grunstein","year":"1975","unstructured":"Grunstein, M. & Hogness, D. S. Proc. natn. Acad. Sci. U.S.A. 72, 3961\u20133965 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF299756a0_CR36","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/0006-291X(66)90447-5","volume":"23","author":"DT Denhardt","year":"1966","unstructured":"Denhardt, D. T. Biochem. biophys. Res. Commun. 23, 641\u2013646 (1966).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF299756a0_CR37","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Nature 227, 680\u2013683 (1970).","journal-title":"Nature"},{"key":"BF299756a0_CR38","first-page":"247","volume":"1","author":"A Atkinson","year":"1979","unstructured":"Atkinson, A. et al. J. appl. Biochem. 1, 247\u2013258 (1979).","journal-title":"J. appl. Biochem."}],"updated-by":[{"DOI":"10.1038\/300546a0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1982,12,9]],"date-time":"1982-12-09T00:00:00Z","timestamp":408240000000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/299756a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/299756a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/299756a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:14:53Z","timestamp":1684286093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/299756a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10]]},"references-count":38,"journal-issue":{"issue":"5885","published-print":{"date-parts":[[1982,10]]}},"alternative-id":["BF299756a0"],"URL":"https:\/\/doi.org\/10.1038\/299756a0","relation":{"correction":[{"id-type":"doi","id":"10.1038\/300546a0","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10]]}}}