{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:23:11Z","timestamp":1791332591435,"version":"4.3.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5941","license":[{"start":{"date-parts":[[1983,11,1]],"date-time":"1983-11-01T00:00:00Z","timestamp":436492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1983,11]]},"DOI":"10.1038\/306398a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T00:03:03Z","timestamp":1100736183000},"page":"398-400","source":"Crossref","is-referenced-by-count":293,"title":["\u03b1-Thalassaemia caused by a polyadenylation signal mutation"],"prefix":"10.1038","volume":"306","author":[{"given":"D. R.","family":"Higgs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. E. Y.","family":"Goodbourn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J.","family":"Proudfoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF306398a0_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/263211a0","volume":"263","author":"NJ Proudfoot","year":"1976","unstructured":"Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211\u2013214 (1976).","journal-title":"Nature"},{"key":"BF306398a0_CR2","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/298516a0","volume":"298","author":"NJ Proudfoot","year":"1982","unstructured":"Proudfoot, N. J. Nature 298, 516\u2013517 (1982).","journal-title":"Nature"},{"key":"BF306398a0_CR3","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0092-8674(81)90521-3","volume":"24","author":"M Fitzgerald","year":"1981","unstructured":"Fitzgerald, M. & Shenk, T. Cell 24, 251\u2013260 (1981).","journal-title":"Cell"},{"key":"BF306398a0_CR4","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/287491a0","volume":"287","author":"EB Ziff","year":"1980","unstructured":"Ziff, E. B. Nature 287, 491\u2013499 (1980).","journal-title":"Nature"},{"key":"BF306398a0_CR5","doi-asserted-by":"crossref","first-page":"7157","DOI":"10.1016\/S0021-9258(18)50298-2","volume":"254","author":"O Hagenbuchle","year":"1980","unstructured":"Hagenbuchle, O., Krikeles, M. S. & Sprague, K. U. J. biol. Chem. 254, 7157\u20137169 (1980).","journal-title":"J. biol. Chem."},{"key":"BF306398a0_CR6","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1073\/pnas.77.10.5759","volume":"77","author":"A Jung","year":"1980","unstructured":"Jung, A., Sippel, A. E., Grez, M. & Schutz, G. Proc. natn. Acad. Sci. U.S.A. 77, 5759\u20135763 (1980).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR7","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1093\/nar\/10.13.3861","volume":"10","author":"J Fornwald","year":"1982","unstructured":"Fornwald, J., Kuncio, G., Peng, I. & Ordahl, C. P. Nucleic Acids Res. 10, 3861\u20133876 (1982).","journal-title":"Nucleic Acids Res."},{"key":"BF306398a0_CR8","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/298857a0","volume":"298","author":"R Zakut","year":"1982","unstructured":"Zakut, R. et al. Nature 298, 857\u2013859 (1982).","journal-title":"Nature"},{"key":"BF306398a0_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/302033a0","volume":"302","author":"DJ Capon","year":"1983","unstructured":"Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33\u201337 (1983).","journal-title":"Nature"},{"key":"BF306398a0_CR10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/JVI.37.1.226-238.1981","volume":"37","author":"L Donehower","year":"1981","unstructured":"Donehower, L., Huang, A. & Hager, G. J. Virol. 37, 226\u2013238 (1981).","journal-title":"J. Virol."},{"key":"BF306398a0_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0092-8674(80)90346-3","volume":"22","author":"DR Setzer","year":"1980","unstructured":"Setzer, D. R., McGrogan, M., Nunberg, J. H. & Schimke, R. T. Cell 22, 361\u2013370 (1980).","journal-title":"Cell"},{"key":"BF306398a0_CR12","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJM198012113032402","volume":"303","author":"L Pressley","year":"1980","unstructured":"Pressley, L. et al. New Engl. J. Med. 303, 1383\u20131388 (1980).","journal-title":"New Engl. J. Med."},{"key":"BF306398a0_CR13","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.1073\/pnas.78.9.5833","volume":"78","author":"DR Higgs","year":"1981","unstructured":"Higgs, D. R. et al. Proc. Natn. Acad. Sci. U.S.A. 78, 5833\u20135837 (1981).","journal-title":"Proc. Natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR14","volume-title":"Molecular Cloning, a Laboratory Manual","author":"T Maniatis","year":"1982","unstructured":"Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning, a Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982)."},{"key":"BF306398a0_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0378-1119(80)90113-4","volume":"12","author":"DL Rimm","year":"1980","unstructured":"Rimm, D. L., Horness, D., Kucera, J. & Blattner, F. R. Gene 12, 301\u2013308 (1980).","journal-title":"Gene"},{"key":"BF306398a0_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0092-8674(81)90324-X","volume":"24","author":"SH Orkin","year":"1981","unstructured":"Orkin, S. H. & Goff, S. C. Cell 24, 345\u2013351 (1981).","journal-title":"Cell"},{"key":"BF306398a0_CR17","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1172\/JCI110273","volume":"68","author":"SA Liebhaber","year":"1981","unstructured":"Liebhaber, S. A. & Kan, Y. W. J. clin. Invest. 68, 439\u2013446 (1981).","journal-title":"J. clin. Invest."},{"key":"BF306398a0_CR18","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1073\/pnas.76.6.2886","volume":"76","author":"JC Chang","year":"1979","unstructured":"Chang, J. C., Kan, Y. W., Trecartin, R. F. & Temple, G. F. Proc. natn. Acad. Sci. U.S.A. 76, 2886\u20132889 (1979).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR19","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1172\/JCI110323","volume":"68","author":"RF Trecartin","year":"1981","unstructured":"Trecartin, R. F. et al. J. Clin. Invest. 68, 1012\u20131017 (1981).","journal-title":"J. Clin. Invest."},{"key":"BF306398a0_CR20","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1093\/nar\/10.18.5421","volume":"10","author":"AJ Kinniburgh","year":"1982","unstructured":"Kinniburgh, A. J. et al. Nucleic Acids Res. 10, 5421\u20135427 (1982).","journal-title":"Nucleic Acids Res."},{"key":"BF306398a0_CR21","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0092-8674(81)90413-X","volume":"27","author":"J Banerji","year":"1981","unstructured":"Banerji, J., Rusconk, S. & Schaffner, W. Cell 27, 299\u2013308 (1981).","journal-title":"Cell"},{"key":"BF306398a0_CR22","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0092-8674(81)90412-8","volume":"27","author":"M Busslinger","year":"1981","unstructured":"Busslinger, M., Moschonas, N. & Flavell, R. A. Cell 27, 289\u2013298 (1981).","journal-title":"Cell"},{"key":"BF306398a0_CR23","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/295120a0","volume":"295","author":"GC Grosveld","year":"1982","unstructured":"Grosveld, G. C., De Boer, E., Shewmaker, C. K. & Flavell, R. A. Nature 295, 120\u2013126 (1982).","journal-title":"Nature"},{"key":"BF306398a0_CR24","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/0092-8674(82)90452-4","volume":"29","author":"R Treisman","year":"1982","unstructured":"Treisman, R., Proudfoot, N. J., Shander, M. & Maniatis, T. Cell 29, 903\u2013911 (1982).","journal-title":"Cell"},{"key":"BF306398a0_CR25","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/0092-8674(78)90071-5","volume":"15","author":"JR Nevins","year":"1978","unstructured":"Nevins, J. R. & Darnell, J. E. Cell 15, 1477\u20131493 (1978).","journal-title":"Cell"},{"key":"BF306398a0_CR26","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/0022-2836(79)90474-1","volume":"129","author":"NW Fraser","year":"1979","unstructured":"Fraser, N. W., Nevins, J. R., Ziff, E. & Darnell, J. E. J. molec. Biol. 129, 643\u2013656 (1979).","journal-title":"J. molec. Biol."},{"key":"BF306398a0_CR27","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/0022-2836(80)90096-0","volume":"144","author":"JR Nevins","year":"1980","unstructured":"Nevins, J. R., Blanchard, J.-M. & Darnell, J. E. J. molec. Biol. 144, 377\u2013386 (1980).","journal-title":"J. molec. Biol."},{"key":"BF306398a0_CR28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/JVI.28.3.795-801.1978","volume":"28","author":"JP Ford","year":"1978","unstructured":"Ford, J. P. & Hsu, M. T. J. Virol. 28, 795\u2013801 (1978).","journal-title":"J. Virol."},{"key":"BF306398a0_CR29","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0092-8674(81)90154-9","volume":"23","author":"E Hofer","year":"1981","unstructured":"Hofer, E. & Darnell, J. E. Jr Cell 23, 585\u2013593 (1981).","journal-title":"Cell"},{"key":"BF306398a0_CR30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/297365a0","volume":"297","author":"JE Darnell","year":"1982","unstructured":"Darnell, J. E. Nature 297, 365\u2013371 (1982).","journal-title":"Nature"},{"key":"BF306398a0_CR31","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0092-8674(80)90347-5","volume":"22","author":"AM Michelson","year":"1980","unstructured":"Michelson, A. M. & Orkin, S. H. Cell 22, 371\u2013377 (1980).","journal-title":"Cell"},{"key":"BF306398a0_CR32","doi-asserted-by":"publisher","first-page":"7054","DOI":"10.1073\/pnas.77.12.7054","volume":"77","author":"SA Liebhaber","year":"1980","unstructured":"Liebhaber, S. A., Goossens, M. J. & Kan, Y. W. Proc. natn. Acad. Sci. U.S.A. 77, 7054\u20137058 (1980).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR33","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1073\/pnas.78.8.5041","volume":"78","author":"SH Orkin","year":"1981","unstructured":"Orkin, S. H., Goff, S. C. & Hechtman, R.L. Proc. natn. Acad. Sci. U.S.A. 78, 5041\u20135045 (1981).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR34","unstructured":"Michelson, A. & Orkin, S. J. biol. Chem.(in the press)."},{"key":"BF306398a0_CR35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","volume":"65","author":"AM Maxam","year":"1980","unstructured":"Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499\u2013560 (1980).","journal-title":"Meth. Enzym."},{"key":"BF306398a0_CR36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1365-2141.1980.tb03810.x","volume":"45","author":"DM Hunt","year":"1980","unstructured":"Hunt, D. M. et al. Br. J. Haemat. 45, 53\u201364 (1980).","journal-title":"Br. J. Haemat."},{"key":"BF306398a0_CR37","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S0076-6879(80)65070-8","volume":"65","author":"JM Favaloro","year":"1980","unstructured":"Favaloro, J. M., Treisman, R. H. & Kamen, R. Meth. Enzym. 65, 718\u2013749 (1980).","journal-title":"Meth. Enzym."},{"key":"BF306398a0_CR38","doi-asserted-by":"publisher","first-page":"5350","DOI":"10.1073\/pnas.74.12.5350","volume":"74","author":"JC Alwine","year":"1977","unstructured":"Alwine, J. C., Kemp, D. J. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 74, 5350\u20135354 (1977).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306398a0_CR39","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(80)90240-8","volume":"20","author":"J Lauer","year":"1980","unstructured":"Lauer, J., Shen, C-K. J. & Maniatis, T. Cell 20, 119\u2013130 (1980).","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/306398a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/306398a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/306398a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:04:38Z","timestamp":1684285478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/306398a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":39,"journal-issue":{"issue":"5941","published-print":{"date-parts":[[1983,11]]}},"alternative-id":["BF306398a0"],"URL":"https:\/\/doi.org\/10.1038\/306398a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11]]}}}