{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:35:46Z","timestamp":1790375746879,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5942","license":[{"start":{"date-parts":[[1983,12,1]],"date-time":"1983-12-01T00:00:00Z","timestamp":439084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1983,12]]},"DOI":"10.1038\/306498a0","type":"journal-article","created":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T19:04:02Z","timestamp":1100718242000},"page":"498-500","source":"Crossref","is-referenced-by-count":71,"title":["Electrostatic interactions in the assembly of haemoglobin"],"prefix":"10.1038","volume":"306","author":[{"given":"H. Franklin","family":"Bunn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisenda J.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF306498a0_CR1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/228726a0","volume":"228","author":"MF Perutz","year":"1970","unstructured":"Perutz, M. F. Nature 228, 726\u2013733 (1970).","journal-title":"Nature"},{"key":"BF306498a0_CR2","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1126\/science.185.4155.905","volume":"185","author":"R Benesch","year":"1974","unstructured":"Benesch, R. & Benesch, R. E. Science 185, 905\u2013908 (1974).","journal-title":"Science"},{"key":"BF306498a0_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0022-2836(65)80261-3","volume":"12","author":"E Antonini","year":"1965","unstructured":"Antonini, E., Bucci, E., Fronticelli, C., Wyman, J. & Rossi-Fanelli, A. J. molec. Biol. 12, 375 (1965).","journal-title":"J. molec. Biol."},{"key":"BF306498a0_CR4","volume-title":"Human Hemoglobins","author":"HF Bunn","year":"1977","unstructured":"Bunn, H. F., Forget, B., Ranney, H. M. Human Hemoglobins (Saunders, Philadelphia, 1977)."},{"key":"BF306498a0_CR5","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1365-2141.1983.tb02042.x","volume":"53","author":"MCM Vissers","year":"1983","unstructured":"Vissers, M. C. M., Winterbourn, C. C. & Carrell, R. W. Br. J. Haemat. 53, 417\u2013422 (1983).","journal-title":"Br. J. Haemat."},{"key":"BF306498a0_CR6","volume-title":"The Thalassemia Syndromes","author":"DJ Weatherall","year":"1981","unstructured":"Weatherall, D. J. & Clegg, J. B. The Thalassemia Syndromes 3rd ed (Blackwell, Oxford, 1981)."},{"key":"BF306498a0_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/ajh.2830140411","volume":"14","author":"THJ Huisman","year":"1983","unstructured":"Huisman, T. H. J. Am. J. Hemat. 14, 393\u2013404 (1983).","journal-title":"Am. J. Hemat."},{"key":"BF306498a0_CR8","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/0022-2836(73)90304-5","volume":"75","author":"M Tainsky","year":"1973","unstructured":"Tainsky, M. & Edelstein, S. J. J. molec. Biol. 75, 735\u2013739 (1973).","journal-title":"J. molec. Biol."},{"key":"BF306498a0_CR9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1073\/pnas.75.1.311","volume":"75","author":"R Valdes","year":"1978","unstructured":"Valdes, R. & Ackers, G. K. Proc. natn. Acad. Sci. U.S.A. 75, 311\u2013314 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306498a0_CR10","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/0003-9861(81)90180-6","volume":"210","author":"A Kurtz","year":"1981","unstructured":"Kurtz, A., Rollema, H. S. & Bauer, C. Archs Biochem. Biophys. 210, 200\u2013203 (1981).","journal-title":"Archs Biochem. Biophys."},{"key":"BF306498a0_CR11","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/0006-291X(78)91662-5","volume":"84","author":"A Kurtz","year":"1978","unstructured":"Kurtz, A. & Bauer, C. Biochem. biophys. Res. Commun. 84, 852\u2013857 (1978).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF306498a0_CR12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0021-9258(17)32800-4","volume":"252","author":"R Valdes","year":"1977","unstructured":"Valdes, R. & Ackers, G. K. J. biol. Chem. 252, 74\u201381 (1977).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR13","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1016\/S0021-9258(19)45073-4","volume":"247","author":"MJ McDonald","year":"1972","unstructured":"McDonald, M. J. & Noble, R. W. J. biol. Chem. 247, 4282\u20134287 (1972).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0021-9258(18)97685-4","volume":"240","author":"E Bucci","year":"1965","unstructured":"Bucci, E. & Fronticelli, C. J. biol. Chem. 240, 551\u2013552 (1965).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR15","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0021-9258(19)41806-1","volume":"250","author":"Y Sugita","year":"1975","unstructured":"Sugita, Y. J. biol. Chem. 250, 1251\u20131256 (1975).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR16","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1016\/S0021-9258(18)43366-2","volume":"256","author":"JS Philo","year":"1981","unstructured":"Philo, J. S., Adams, M. L. & Schuster, T. M. J. biol. Chem. 256, 7917\u20137924 (1981).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR17","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1016\/S0021-9258(19)69191-X","volume":"256","author":"MJ McDonald","year":"1981","unstructured":"McDonald, M. J. J. biol. Chem. 256, 6487\u20136490 (1981).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0006-291X(83)80116-8","volume":"111","author":"SM Turci","year":"1983","unstructured":"Turci, S. M. & McDonald, M. J. Biochem. biophys. Res. Commun. 111, 55\u201360 (1983).","journal-title":"Biochem. biophys. Res. Commun."},{"key":"BF306498a0_CR19","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3109\/03630267709003912","volume":"1","author":"EC Abraham","year":"1977","unstructured":"Abraham, E. C. & Huisman, T. H. J. Haemoglobin 1, 861\u2013873 (1977).","journal-title":"Haemoglobin"},{"key":"BF306498a0_CR20","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/276631a0","volume":"276","author":"JR Shaeffer","year":"1978","unstructured":"Shaeffer, J. R., Kingston, R. E., McDonald, M. J. & Bunn, H. F. Nature 276, 631\u2013633 (1978).","journal-title":"Nature"},{"key":"BF306498a0_CR21","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/S0021-9258(19)85893-3","volume":"255","author":"JR Shaeffer","year":"1980","unstructured":"Shaeffer, J. R. J. biol. Chem. 255, 2322\u20132324 (1980).","journal-title":"J. biol. Chem."},{"key":"BF306498a0_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0021-9673(00)98537-6","volume":"127","author":"PG Righetti","year":"1976","unstructured":"Righetti, P. G. & Caravaggio, T. J. Chromatog. 127, 1\u201328 (1976).","journal-title":"J. Chromatog."},{"key":"BF306498a0_CR23","doi-asserted-by":"publisher","first-page":"7527","DOI":"10.1073\/pnas.79.23.7527","volume":"79","author":"HF Bunn","year":"1982","unstructured":"Bunn, H. F. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7527\u20137531 (1982).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306498a0_CR24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/222295a0","volume":"222","author":"A Bank","year":"1969","unstructured":"Bank, A. & O'Donnell, J. V. Nature 222, 295\u2013296 (1969).","journal-title":"Nature"},{"key":"BF306498a0_CR25","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1073\/pnas.72.10.3853","volume":"72","author":"G Chalevelakis","year":"1975","unstructured":"Chalevelakis, G., Clegg, J. B. & Weatherall, D. J. Proc. natn. Acad. Sci. U.S.A. 72, 3853\u20133857 (1975).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306498a0_CR26","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1073\/pnas.75.7.3427","volume":"75","author":"SM Hanash","year":"1978","unstructured":"Hanash, S. M. & Rucknagel, D. L. Proc. natn. Acad. Sci. U.S.A. 75, 3427\u20133431 (1978).","journal-title":"Proc. natn. Acad. Sci. U.S.A."},{"key":"BF306498a0_CR27","first-page":"352","volume":"98","author":"V Testa","year":"1981","unstructured":"Testa, V. et al. J. Lab. clin. Med. 98, 352\u2013363 (1981).","journal-title":"J. Lab. clin. Med."},{"key":"BF306498a0_CR28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1182\/blood.V57.5.967.967","volume":"57","author":"GB Sancar","year":"1981","unstructured":"Sancar, G. B., Cedeno, M. M. & Rieder, R. F. Blood 57, 967\u2013971 (1981).","journal-title":"Blood"},{"key":"BF306498a0_CR29","doi-asserted-by":"crossref","first-page":"38a","DOI":"10.1182\/blood.V60.1.38.38","volume":"60","author":"JR Shaeffer","year":"1982","unstructured":"Shaeffer, J. R. Blood 60, 38a (1982).","journal-title":"Blood"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/306498a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/306498a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/306498a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T21:06:12Z","timestamp":1684271172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/306498a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,12]]},"references-count":29,"journal-issue":{"issue":"5942","published-print":{"date-parts":[[1983,12]]}},"alternative-id":["BF306498a0"],"URL":"https:\/\/doi.org\/10.1038\/306498a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,12]]}}}