{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:16:56Z","timestamp":1790853416800,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5964","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[1984,5]]},"DOI":"10.1038\/309163a0","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T02:42:07Z","timestamp":1100745727000},"page":"163-165","source":"Crossref","is-referenced-by-count":617,"title":["Atypical \u03b2-adrenoceptor on brown adipocytes as target for anti-obesity drugs"],"prefix":"10.1038","volume":"309","author":[{"given":"J. R. S.","family":"Arch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Ainsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Cawthorne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Piercy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Sennitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. E.","family":"Thody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BF309163a0_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/281031a0","volume":"281","author":"NJ Rothwell","year":"1979","unstructured":"Rothwell, N. J. & Stock, M. J. Nature 281, 31\u201335 (1979).","journal-title":"Nature"},{"key":"BF309163a0_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/BF00584784","volume":"389","author":"NJ Rothwell","year":"1981","unstructured":"Rothwell, N. J. & Stock, M. J. Pfl\u00fcgers Arch. ges. Physiol. 389, 237\u2013242 (1981).","journal-title":"Pfl\u00fcgers Arch. ges. Physiol."},{"key":"BF309163a0_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/BF00647457","volume":"385","author":"PL Thurlby","year":"1980","unstructured":"Thurlby, P. L. & Trayhurn, P. Pfl\u00fcgers Arch. ges. Physiol. 385, 193\u2013201 (1980).","journal-title":"Pfl\u00fcgers Arch. ges. Physiol."},{"key":"BF309163a0_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/295323a0","volume":"295","author":"P Trayhurn","year":"1982","unstructured":"Trayhurn, P., Jones, P. M., McGuckin, M. M. & Goodbody, A. E. Nature 295, 323\u2013325 (1982).","journal-title":"Nature"},{"key":"BF309163a0_CR5","first-page":"481","volume":"6","author":"SJ Wickler","year":"1982","unstructured":"Wickler, S. J., Horwitz, B. A. & Stern, J. S. Int. J. Obesity 6, 481\u2013490 (1982).","journal-title":"Int. J. Obesity"},{"key":"BF309163a0_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF00582702","volume":"390","author":"J Seydoux","year":"1981","unstructured":"Seydoux, J., Rohner-Jeanrenaud, F., Assimacopoulos-Jeannet, F., Jeanrenaud, B. & Girardier, L. Pfl\u00fcgers Arch. ges. Physiol. 390, 1\u20134 (1981).","journal-title":"Pfl\u00fcgers Arch. ges. Physiol."},{"key":"BF309163a0_CR7","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1079\/BJN19820077","volume":"47","author":"E Connolly","year":"1982","unstructured":"Connolly, E., Morrisey, R. D. & Carnie, J. A. Br. J. Nutr. 47, 653\u2013658 (1982).","journal-title":"Br. J. Nutr."},{"key":"BF309163a0_CR8","doi-asserted-by":"crossref","first-page":"12840","DOI":"10.1016\/S0021-9258(18)42972-9","volume":"256","author":"LJ Bukowiecki","year":"1981","unstructured":"Bukowiecki, L. J., Foll\u00e9a, N., Lupien, J. & Paradis, A. J. biol. Chem. 256, 12840\u201312848 (1981).","journal-title":"J. biol. Chem."},{"key":"BF309163a0_CR9","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1432-1033.1982.tb07060.x","volume":"129","author":"RM Locke","year":"1982","unstructured":"Locke, R. M., Rial, E., Scott, I. D. & Nicholls, D. G. Eur. J. Biochem. 129, 373\u2013380 (1982).","journal-title":"Eur. J. Biochem."},{"key":"BF309163a0_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0165-6147(82)90987-7","volume":"3","author":"A Arnold","year":"1982","unstructured":"Arnold, A. Trends pharmac. Sci. 3, 7 (1982).","journal-title":"Trends pharmac. Sci."},{"key":"BF309163a0_CR11","first-page":"347","volume":"1","author":"MJ Daly","year":"1979","unstructured":"Daly, M. J. & Levy, G. P. Trends Autonomic Pharmac. 1, 347\u2013385 (1979).","journal-title":"Trends Autonomic Pharmac."},{"key":"BF309163a0_CR12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1146\/annurev.ne.04.030181.002223","volume":"4","author":"KP Minneman","year":"1981","unstructured":"Minneman, K. P., Pittman, R. M. & Molinoff, P. B. A. Rev. Neurosci. 4, 419\u2013461 (1981).","journal-title":"A. Rev. Neurosci."},{"key":"BF309163a0_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/0165-6147(81)90276-5","volume":"2","author":"SR Nahorski","year":"1981","unstructured":"Nahorski, S. R. Trends pharmac. Sci. 2, 95\u201398 (1981).","journal-title":"Trends pharmac. Sci."},{"key":"BF309163a0_CR14","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/214597a0","volume":"214","author":"AM Lands","year":"1967","unstructured":"Lands, A. M., Arnold, A., McAuliff, J. P., Luduena, F. P. & Brown, T. G. Jr. Nature 214, 597\u2013598 (1967).","journal-title":"Nature"},{"key":"BF309163a0_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1432-1033.1978.tb12737.x","volume":"92","author":"L Bukowiecki","year":"1978","unstructured":"Bukowiecki, L., Foll\u00e9a, N., Vallieres, J. & LeBlanc, J. Eur. J. Biochem. 92, 189\u2013196 (1978).","journal-title":"Eur. J. Biochem."},{"key":"BF309163a0_CR16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1432-1033.1979.tb06281.x","volume":"102","author":"P Svoboda","year":"1979","unstructured":"Svoboda, P., Svartengren, J., Snochowski, M., Hou\u0161t\u011bk, J. & Cannon, B. Eur. J. Biochem 102, 203\u20132101979).","journal-title":"Eur. J. Biochem"},{"key":"BF309163a0_CR17","first-page":"E552","volume":"238","author":"L Bukowieki","year":"1980","unstructured":"Bukowieki, L., Foll\u00e9a, N., Paradis, A. & Collet, A. Am. J. Physiol. 238, E552\u2013563 (1980).","journal-title":"Am. J. Physiol."},{"key":"BF309163a0_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0163-7258(82)90016-X","volume":"17","author":"NJ Rothwell","year":"1982","unstructured":"Rothwell, N. J., Stock, M. J. & Stribling, D. Pharmac. Ther. 17, 251\u2013268 (1982).","journal-title":"Pharmac. Ther."},{"key":"BF309163a0_CR19","first-page":"286","volume-title":"Catecholamines","author":"RF Furchgott","year":"1972","unstructured":"Furchgott, R. F. in Catecholamines (eds Blaschko, H. & Muscholl, E.) 286\u2013335 (Springer, Berlin, 1972)."},{"key":"BF309163a0_CR20","unstructured":"Wilson, C., Wilson, S., Piercy, V., Sennitt, M. V. & Arch, J. R. S. Eur. J. Pharmac. (in the press)."},{"key":"BF309163a0_CR21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0014-2999(72)90104-5","volume":"19","author":"SR O'Donnell","year":"1972","unstructured":"O'Donnell, S. R. Eur. J. Pharmac. 19, 371\u2013379 (1972).","journal-title":"Eur. J. Pharmac."},{"key":"BF309163a0_CR22","first-page":"406","volume":"213","author":"TP Kenakin","year":"1980","unstructured":"Kenakin, T. P. & Beek, D. J. Pharmac. exp. Ther. 213, 406\u2013413 (1980).","journal-title":"J. Pharmac. exp. Ther."},{"key":"BF309163a0_CR23","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.2042-7158.1978.tb13237.x","volume":"30","author":"D MacKay","year":"1978","unstructured":"MacKay, D. J. Pharm. Pharmac. 30, 312\u2013313 (1978).","journal-title":"J. Pharm. Pharmac."},{"key":"BF309163a0_CR24","unstructured":"Arch, J. R. S. et al. Int. J. Obesity (in the press)."},{"key":"BF309163a0_CR25","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1432-1033.1978.tb12045.x","volume":"82","author":"GM Heaton","year":"1978","unstructured":"Heaton, G. M., Wagenvoord, R. J., Kemp, A. & Nicholls, D. G. Eur. J. Biochem. 82, 515\u2013521 (1978).","journal-title":"Eur. J. Biochem."},{"key":"BF309163a0_CR26","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1139\/o78-060","volume":"56","author":"M Desautels","year":"1978","unstructured":"Desautels, M., Zaror-Behrens, G. & Himms-Hagen, J. Can. J. Biochem. 56, 378\u2013383 (1978).","journal-title":"Can. J. Biochem."},{"key":"BF309163a0_CR27","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/ajcn\/38.4.549","volume":"38","author":"JRS Arch","year":"1983","unstructured":"Arch, J. R. S. & Ainsworth, A. T. Am. J. clin. Nutr. 38, 549\u2013558 (1983).","journal-title":"Am. J. clin. Nutr."},{"key":"BF309163a0_CR28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0014-2999(74)90098-3","volume":"25","author":"HH Harms","year":"1974","unstructured":"Harms, H. H., Zaagsma, J. & van der Wal, B. Eur. J. Pharmac. 25, 87\u201391 (1974).","journal-title":"Eur. J. Pharmac."},{"key":"BF309163a0_CR29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0014-2999(80)90118-1","volume":"63","author":"J De Vente","year":"1980","unstructured":"De Vente, J., Bast, A. van Bree, L. & Zaagsma, J. Eur. J. Pharmac. 63, 73\u201383 (1980).","journal-title":"Eur. J. Pharmac."},{"key":"BF309163a0_CR30","first-page":"409","volume":"7","author":"S Tan","year":"1983","unstructured":"Tan, S. & Curtis-Prior, P. B. Int. J. Obesity 7, 409\u2013414 (1983).","journal-title":"Int. J. Obesity"},{"key":"BF309163a0_CR31","doi-asserted-by":"crossref","unstructured":"Bojanic, D., Jansen, J. D., Nahorski, S. R. & Zaagsma, J. Br. J. Pharmac. 81, Suppl. 4P (1984).","DOI":"10.3109\/10799898409042537"},{"key":"BF309163a0_CR32","first-page":"299","volume":"143","author":"JM Van Rossum","year":"1963","unstructured":"Van Rossum, J. M. Archs int. Pharmacodyn. 143, 299\u2013330 (1963).","journal-title":"Archs int. Pharmacodyn."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/309163a0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/309163a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/309163a0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:21:48Z","timestamp":1684286508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/309163a0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":32,"journal-issue":{"issue":"5964","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["BF309163a0"],"URL":"https:\/\/doi.org\/10.1038\/309163a0","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}